pI: 8.5096 |
Length (AA): 461 |
MW (Da): 52494 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
193 | 354 | 2p8r (A) | 2098 | 2258 | 14.00 | 0 | 0.7 | 0.48411 | -0.22 |
204 | 346 | 5cw4 (A) | 23 | 175 | 17.00 | 0.000042 | 0.99 | 0.482295 | 0.07 |
213 | 359 | 2znr (A) | 294 | 434 | 17.00 | 0 | 1 | 0.460572 | 0.13 |
279 | 342 | 1n3l (A) | 186 | 260 | 31.00 | 0.78 | 0.05 | 0.322329 | 0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128565)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G47970 | Nuclear pore localisation protein NPL4 |
Arabidopsis thaliana | AT3G63000 | NPL4-like protein 1 |
Babesia bovis | BBOV_II006090 | NPL4 family protein |
Brugia malayi | Bm1_17260 | NPL4 family protein |
Candida albicans | CaO19.9970 | nuclear pore-associated protein |
Candida albicans | CaO19.2434 | nuclear pore-associated protein |
Caenorhabditis elegans | CELE_F59E12.5 | Protein NPL-4.2, isoform B |
Caenorhabditis elegans | CELE_F59E12.4 | Protein NPL-4.1, isoform B |
Cryptosporidium hominis | Chro.70227 | hypothetical protein |
Cryptosporidium parvum | cgd7_1970 | nuclear pore associated protein (NLP4) with N-terminal ubiquitin domain |
Dictyostelium discoideum | DDB_G0290227 | nuclear protein localization 4 |
Drosophila melanogaster | Dmel_CG4673 | Npl4 ortholog |
Echinococcus granulosus | EgrG_001148600 | nuclear protein localization protein 4 |
Entamoeba histolytica | EHI_026450 | hypothetical protein |
Echinococcus multilocularis | EmuJ_001148600 | nuclear protein localization protein 4 |
Homo sapiens | ENSG00000182446 | nuclear protein localization 4 homolog (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_01260 | NPL4 family protein |
Mus musculus | ENSMUSG00000039703 | nuclear protein localization 4 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_035470 | hypothetical protein, conserved |
Oryza sativa | 4325451 | Os01g0377700 |
Onchocerca volvulus | OVOC10940 | Nuclear protein localization protein 4 homolog |
Plasmodium berghei | PBANKA_1107300 | nuclear protein localization protein 4, putative |
Plasmodium falciparum | PF3D7_0507700 | nuclear protein localization protein 4, putative |
Plasmodium knowlesi | PKNH_1025900 | nuclear protein localization protein 4, putative |
Plasmodium vivax | PVX_097945 | hypothetical protein, conserved |
Plasmodium yoelii | PY05126 | Drosophila melanogaster GH03617p |
Saccharomyces cerevisiae | YBR170C | Npl4p |
Schistosoma japonicum | Sjp_0085950 | Nuclear protein localization protein 4 homolog, putative |
Schistosoma mansoni | Smp_039180.2 | nuclear protein localization |
Schistosoma mansoni | Smp_039180.1 | nuclear protein localization |
Schmidtea mediterranea | mk4.000287.04 | Nuclear protein localization protein 4 homolog |
Schmidtea mediterranea | mk4.003986.00 | Nuclear protein localization protein 4 homolog |
Schmidtea mediterranea | mk4.033436.00 | Nuclear protein localization protein 4 homolog |
Schmidtea mediterranea | mk4.001872.07 | Nuclear protein localization protein 4 homolog |
Schmidtea mediterranea | mk4.020071.02 | Nuclear protein localization protein 4 homolog |
Schmidtea mediterranea | mk4.006207.02 | Nuclear protein localization protein 4 homolog |
Toxoplasma gondii | TGME49_271440 | NPL4 family protein |
Theileria parva | TP02_0563 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_471060 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F59E12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F59E12.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F59E12.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F59E12.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F59E12.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F59E12.5 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1107300 | Plasmodium berghei | Essential | plasmo |
TGME49_271440 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Fatty acid-binding protein, adipocyte | 132 aa | 22.0% | 109 aa | Compounds | References |