Detailed view for EHI_120930

Basic information

TDR Targets ID: 801118
Entamoeba histolytica, protein kinase domain containing protein
Source Database / ID:  AmoebaDB  

pI: 6.8623 | Length (AA): 1364 | MW (Da): 156539 | Paralog Number: 58

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
951 1362 2c0t (A) 93 496 24.00 0 1 0.446653 0.6
1085 1361 3bkb (A) 550 819 24.00 0 1 0.549679 -0.72
1089 1358 2dq7 (X) 4 262 28.00 0 1 0.524547 -0.42
1098 1333 5uis (D) 182 405 39.00 0.0000000011 1 0.275521 0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_126560)

Species Accession Gene Product
Brugia malayi Bm1_15385   Protein kinase domain containing protein
Caenorhabditis elegans CELE_C18H7.4   Protein C18H7.4
Drosophila melanogaster Dmel_CG6124   CG6124 gene product from transcript CG6124-RC
Drosophila melanogaster Dmel_CG13492   CG13492 gene product from transcript CG13492-RD
Echinococcus granulosus EgrG_000742100   hypothetical protein
Echinococcus granulosus EgrG_000149500   expressed conserved protein
Echinococcus granulosus EgrG_000739000   hypothetical protein
Echinococcus granulosus EgrG_000420000   microtubule associated protein
Echinococcus granulosus EgrG_000997200   fibrillin 1
Echinococcus granulosus EgrG_000896800   hypothetical protein
Echinococcus granulosus EgrG_000881300   coiled coil domain containing protein 41
Entamoeba histolytica EHI_195050   tyrosine kinase, putative
Entamoeba histolytica EHI_066510   protein kinase, putative
Entamoeba histolytica EHI_165920   hypothetical protein
Entamoeba histolytica EHI_185130   protein kinase, putative
Entamoeba histolytica EHI_061870   hypothetical protein, conserved
Entamoeba histolytica EHI_092250   hypothetical protein
Entamoeba histolytica EHI_092300   protein kinase, putative
Entamoeba histolytica EHI_001630   hypothetical protein
Entamoeba histolytica EHI_180320   tyrosine kinase, putative
Entamoeba histolytica EHI_034210   protein kinase domain containing protein
Entamoeba histolytica EHI_109470   hypothetical protein
Entamoeba histolytica EHI_158180   tyrosine kinase, putative
Entamoeba histolytica EHI_157150   protein kinase, putative
Entamoeba histolytica EHI_062090   protein kinase domain containing protein
Entamoeba histolytica EHI_201080   protein kinase domain containing protein
Entamoeba histolytica EHI_174080   protein kinase, putative
Entamoeba histolytica EHI_116260   cysteine surface protein, putative
Entamoeba histolytica EHI_127820   tyrosine kinase, putative
Entamoeba histolytica EHI_114430   hypothetical protein
Entamoeba histolytica EHI_091840   cysteine surface protein, putative
Entamoeba histolytica EHI_118410   tyrosine kinase, putative
Entamoeba histolytica EHI_110650   tyrosine kinase, putative
Entamoeba histolytica EHI_073660   tyrosine kinase, putative
Entamoeba histolytica EHI_082260   CXXC-rich protein
Entamoeba histolytica EHI_160750   cysteine surface protein, putative
Entamoeba histolytica EHI_064490   tyrosine kinase, putative
Entamoeba histolytica EHI_120930   protein kinase domain containing protein
Entamoeba histolytica EHI_104720   hypothetical protein
Entamoeba histolytica EHI_115050   protein kinase, putative
Entamoeba histolytica EHI_127440   tyrosine kinase, putative
Entamoeba histolytica EHI_092260   tyrosine kinase, putative
Entamoeba histolytica EHI_103240   protein kinase domain containing protein
Entamoeba histolytica EHI_030860   cysteine surface protein, putative
Entamoeba histolytica EHI_128800   hypothetical protein
Entamoeba histolytica EHI_119250   tyrosine kinase, putative
Entamoeba histolytica EHI_050820   tyrosine kinase, putative
Entamoeba histolytica EHI_195370   protein kinase domain containing protein
Entamoeba histolytica EHI_058930   tyrosine kinase, putative
Entamoeba histolytica EHI_087880   pro protein convertase subtilisin/kexinType 5 precursor, putative
Entamoeba histolytica EHI_117680   tyrosine kinase, putative
Entamoeba histolytica EHI_178610   tyrosine kinase, putative
Entamoeba histolytica EHI_184810   tyrosine kinase, putative
Entamoeba histolytica EHI_009130   hypothetical protein
Entamoeba histolytica EHI_135730   tyrosine kinase, putative
Entamoeba histolytica EHI_051910   protein kinase, putative
Entamoeba histolytica EHI_050650   protein kinase, putative
Entamoeba histolytica EHI_070110   tyrosine kinase, putative
Entamoeba histolytica EHI_175920   protein kinase, putative
Entamoeba histolytica EHI_124500   tyrosine kinase, putative
Entamoeba histolytica EHI_059040   protein kinase domain containing protein
Entamoeba histolytica EHI_017760   tyrosine kinase, putative
Entamoeba histolytica EHI_114420   tyrosine kinase, putative
Entamoeba histolytica EHI_074740   tyrosine kinase, putative
Entamoeba histolytica EHI_152420   tyrosine kinase, putative
Entamoeba histolytica EHI_050480   tyrosine kinase, putative
Entamoeba histolytica EHI_123840   tyrosine kinase, putative
Entamoeba histolytica EHI_009580   tyrosine kinase, putative
Entamoeba histolytica EHI_011170   protein kinase, putative
Entamoeba histolytica EHI_068160   tyrosine kinase, putative
Echinococcus multilocularis EmuJ_000739000   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000197500   conserved hypothetical protein
Echinococcus multilocularis EmuJ_000997200   fibrillin 1
Echinococcus multilocularis EmuJ_000420000   microtubule associated protein
Echinococcus multilocularis EmuJ_000149500   expressed conserved protein
Echinococcus multilocularis EmuJ_000881300   coiled coil domain containing protein 41
Echinococcus multilocularis EmuJ_000742100   conserved hypothetical protein
Giardia lamblia GL50803_114180   High cysteine membrane protein TMK-like
Giardia lamblia GL50803_113416   High cysteine membrane protein TMK-like
Giardia lamblia GL50803_113319   High cysteine membrane protein TMK-like
Giardia lamblia GL50803_40376   High cysteine non-variant cyst protein
Giardia lamblia GL50803_11309   High cysteine membrane protein Group 1
Homo sapiens ENSG00000099139   proprotein convertase subtilisin/kexin type 5
Leishmania braziliensis LbrM.04.0670   surface antigen-like protein
Leishmania braziliensis LbrM.04.0260   surface antigen-like protein
Leishmania braziliensis LbrM.04.1260   surface antigen-like protein
Leishmania infantum LinJ.04.0170   surface antigen-like protein
Leishmania major LmjF.04.0180   surface antigen-like protein
Leishmania mexicana LmxM.04.0180   surface antigen-like protein
Loa Loa (eye worm) LOAG_07469   TK/FER protein kinase
Mus musculus 675947   multiple epidermal growth factor-like domains protein 6-like
Mus musculus ENSMUSG00000024713   proprotein convertase subtilisin/kexin type 5
Mus musculus 102632425   predicted gene, 30500
Mus musculus 102635385   predicted gene, 32742
Onchocerca volvulus OVOC9434  
Onchocerca volvulus OVOC116  
Schistosoma japonicum Sjp_0026960   IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as
Schistosoma japonicum Sjp_0027000   Neurogenic locus notch protein homolog precursor, putative
Schistosoma japonicum Sjp_0026990   IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a
Schistosoma mansoni Smp_143300   notch
Schmidtea mediterranea mk4.000888.04  
Schmidtea mediterranea mk4.004694.04  
Schmidtea mediterranea mk4.013597.00  
Schmidtea mediterranea mk4.003339.04  
Schmidtea mediterranea mk4.003164.00  
Schmidtea mediterranea mk4.016797.00   Neuroendocrine convertase 1
Schmidtea mediterranea mk4.017291.00  
Schmidtea mediterranea mk4.008484.01  
Schmidtea mediterranea mk4.003589.00  
Schmidtea mediterranea mk4.011126.01  
Schmidtea mediterranea mk4.030338.00  
Schmidtea mediterranea mk4.005594.00  
Schmidtea mediterranea mk4.001239.01  
Schmidtea mediterranea mk4.000675.02  
Schmidtea mediterranea mk4.004105.02  
Schmidtea mediterranea mk4.030870.00  
Schmidtea mediterranea mk4.001659.05  
Schmidtea mediterranea mk4.004935.00  
Schmidtea mediterranea mk4.001500.02  
Schmidtea mediterranea mk4.000058.15  
Schmidtea mediterranea mk4.018176.01  
Schmidtea mediterranea mk4.002170.03  
Schmidtea mediterranea mk4.001212.08  
Schmidtea mediterranea mk4.038707.00  
Schmidtea mediterranea mk4.003478.02  
Schmidtea mediterranea mk4.004254.02  
Schmidtea mediterranea mk4.007110.00  
Schmidtea mediterranea mk4.001249.05  
Schmidtea mediterranea mk4.001149.04  
Schmidtea mediterranea mk4.000130.07  
Schmidtea mediterranea mk4.024648.00  
Schmidtea mediterranea mk4.016045.01  
Schmidtea mediterranea mk4.018150.00  
Schmidtea mediterranea mk4.001169.05  
Schmidtea mediterranea mk4.029530.01  
Schmidtea mediterranea mk4.000590.09  
Schmidtea mediterranea mk4.018261.01  
Schmidtea mediterranea mk4.012925.01  
Schmidtea mediterranea mk4.005174.02  
Schmidtea mediterranea mk4.029901.00  
Schmidtea mediterranea mk4.000139.16  
Schmidtea mediterranea mk4.000261.11  
Schmidtea mediterranea mk4.000107.06  
Schmidtea mediterranea mk4.004016.00  
Schmidtea mediterranea mk4.061877.00  
Schmidtea mediterranea mk4.011706.00  
Schmidtea mediterranea mk4.010766.03  
Schmidtea mediterranea mk4.001481.01  
Schmidtea mediterranea mk4.002345.03  
Schmidtea mediterranea mk4.030136.00  
Schmidtea mediterranea mk4.024626.01  
Schmidtea mediterranea mk4.000227.09  
Schmidtea mediterranea mk4.000030.16  
Schmidtea mediterranea mk4.032778.01  
Schmidtea mediterranea mk4.000792.08  
Schmidtea mediterranea mk4.002223.05  
Schmidtea mediterranea mk4.011275.00  
Schmidtea mediterranea mk4.000540.01  
Schmidtea mediterranea mk4.009484.01  
Schmidtea mediterranea mk4.017107.02  
Schmidtea mediterranea mk4.002588.03  
Schmidtea mediterranea mk4.021927.00  
Schmidtea mediterranea mk4.028315.00  
Schmidtea mediterranea mk4.001655.02  
Schmidtea mediterranea mk4.002543.01  
Schmidtea mediterranea mk4.000614.09  
Schmidtea mediterranea mk4.000639.02  
Schmidtea mediterranea mk4.003107.08  
Schmidtea mediterranea mk4.023252.01  
Schmidtea mediterranea mk4.002421.03  
Schmidtea mediterranea mk4.000341.13  
Schmidtea mediterranea mk4.001082.02  
Schmidtea mediterranea mk4.029099.00  
Schmidtea mediterranea mk4.003024.02  
Schmidtea mediterranea mk4.005609.01  
Schmidtea mediterranea mk4.027530.00  
Schmidtea mediterranea mk4.000275.10  
Schmidtea mediterranea mk4.001648.02  
Schmidtea mediterranea mk4.000964.03  
Schmidtea mediterranea mk4.007576.04  
Schmidtea mediterranea mk4.000789.02  
Schmidtea mediterranea mk4.029176.01  
Schmidtea mediterranea mk4.018982.00  
Schmidtea mediterranea mk4.076520.00  
Schmidtea mediterranea mk4.040413.01  
Schmidtea mediterranea mk4.001911.05  
Schmidtea mediterranea mk4.000385.17  
Schmidtea mediterranea mk4.000199.16  
Schmidtea mediterranea mk4.000310.04  
Schmidtea mediterranea mk4.001083.05  
Schmidtea mediterranea mk4.005821.01  
Schmidtea mediterranea mk4.018641.00  
Schmidtea mediterranea mk4.002780.04  
Schmidtea mediterranea mk4.003005.03  
Schmidtea mediterranea mk4.021344.00  
Schmidtea mediterranea mk4.003304.01  
Schmidtea mediterranea mk4.016618.01  
Schmidtea mediterranea mk4.001842.06  
Schmidtea mediterranea mk4.019327.01  
Schmidtea mediterranea mk4.005503.01  
Schmidtea mediterranea mk4.000084.00  
Schmidtea mediterranea mk4.006496.03  
Schmidtea mediterranea mk4.003242.01  
Schmidtea mediterranea mk4.002371.04  
Schmidtea mediterranea mk4.001246.01  
Schmidtea mediterranea mk4.006952.00  
Schmidtea mediterranea mk4.000290.04  
Schmidtea mediterranea mk4.005012.01  
Schmidtea mediterranea mk4.015935.00  
Schmidtea mediterranea mk4.001175.04  
Schmidtea mediterranea mk4.002404.00  
Schmidtea mediterranea mk4.004662.01  
Schmidtea mediterranea mk4.007591.01  
Schmidtea mediterranea mk4.015006.01  
Schmidtea mediterranea mk4.018744.01  
Schmidtea mediterranea mk4.015751.00  
Schmidtea mediterranea mk4.000007.28  
Schmidtea mediterranea mk4.017532.00  
Schmidtea mediterranea mk4.000149.10  
Schmidtea mediterranea mk4.001698.05  
Schmidtea mediterranea mk4.000476.02  
Schmidtea mediterranea mk4.000062.13  
Schmidtea mediterranea mk4.001117.01  
Schmidtea mediterranea mk4.000186.07  
Schmidtea mediterranea mk4.000364.10  
Schmidtea mediterranea mk4.004953.02  
Schmidtea mediterranea mk4.018076.01  
Schmidtea mediterranea mk4.048035.00  
Schmidtea mediterranea mk4.026805.00  
Schmidtea mediterranea mk4.000315.13  
Schmidtea mediterranea mk4.002349.02  
Schmidtea mediterranea mk4.001962.04  
Schmidtea mediterranea mk4.003248.07  
Schmidtea mediterranea mk4.032023.01  
Schmidtea mediterranea mk4.003706.05  
Schmidtea mediterranea mk4.028804.01  
Schmidtea mediterranea mk4.000302.03  
Schmidtea mediterranea mk4.001620.00  
Schmidtea mediterranea mk4.021527.00  
Schmidtea mediterranea mk4.000903.06  
Schmidtea mediterranea mk4.000249.06  
Schmidtea mediterranea mk4.008810.02  
Schmidtea mediterranea mk4.002114.00  
Schmidtea mediterranea mk4.001317.01  
Schmidtea mediterranea mk4.002960.10  
Schmidtea mediterranea mk4.027026.00  
Trypanosoma cruzi TcCLB.509267.20   hypothetical protein
Trypanosoma cruzi TcCLB.511545.110   hypothetical protein
Trypanosoma cruzi TcCLB.506819.20   hypothetical protein
Trichomonas vaginalis TVAG_RG_DS113182_6   DNA double-strand break repair Rad50 ATPase, putative
Trichomonas vaginalis TVAG_RG_DS113422_10   conserved hypothetical protein
Trichomonas vaginalis TVAG_RG_DS113274_6   Involucrin, putative
Trichomonas vaginalis TVAG_RG_DS113721_3   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proprotein convertase subtilisin/kexin type 5 Compounds References
Human herpesvirus 8 ORF 73 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 23.9% 293 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 23.9% 293 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.6% 264 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 23.9% 293 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 26.8% 209 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0092 1 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0042 0.5 0.5
0.0007 0.5 0.5
0.0029 0.5 0.5
0.0069 0.3067 0.5
0.0016 0.5 0.5
0.0023 0.5 0.5
0.0037 1 0.5
0.0088 0.4477 0.5
0.0036 0.5 0.5
0.0067 0.5 0.5
0.0008 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0061 0.6883 0.6247
0.0007 0.5 0.5
0.0062 0.6935 0
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0033 0.5 0.5
0.0003 0.5 0.5
0.0011 1 0.5
0.0039 0.5 0.5
0.0027 1 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0063 1 1
0.0093 0.8828 0
0.0032 0.5 0.5
0.0016 0.5 0.5
0.0059 1 1
0.0039 0.9485 0.5
0.0039 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.3167
0.0063 0.7244 0
0.0059 1 1
0.0056 1 0.5
0.0033 1 1
0.0091 1 0.5
0.0022 0.5 0.5
0.0064 0.3377 0.8757
0.0081 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_120930 (Entamoeba histolytica), protein kinase domain containing protein
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