pI: 5.9592 |
Length (AA): 186 |
MW (Da): 21316 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 184 | 2qor (A) | 1 | 189 | 33.00 | 0 | 1 | 1.43085 | -0.72 |
2 | 186 | 3tr0 (A) | 2 | 186 | 38.00 | 0.00000000007 | 1 | 1.52592 | -0.74 |
5 | 185 | 1lvg (A) | 5 | 189 | 43.00 | 0 | 1 | 1.53672 | -0.89 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_126916)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G06200 | putative guanylate kinase |
Arabidopsis thaliana | AT2G41880 | guanylate kinase 1 |
Arabidopsis thaliana | AT3G57550 | guanylate kinase |
Babesia bovis | BBOV_II006160 | guanylate kinase, putative |
Brugia malayi | Bm1_09150 | guanylate kinase |
Candida albicans | CaO19.8712 | guanylate kinase |
Candida albicans | CaO19.1115 | guanylate kinase |
Caenorhabditis elegans | CELE_T03F1.8 | Protein GUK-1, isoform B |
Cryptosporidium hominis | Chro.70250 | hypothetical protein |
Cryptosporidium parvum | cgd7_2190 | putative guanylate kinase |
Chlamydia trachomatis | CT_030 | guanylate kinase |
Dictyostelium discoideum | DDB_G0279001 | guanylate kinase |
Drosophila melanogaster | Dmel_CG11811 | CG11811 gene product from transcript CG11811-RA |
Escherichia coli | b3648 | guanylate kinase |
Echinococcus granulosus | EgrG_001029200 | guanylate kinase |
Entamoeba histolytica | EHI_118910 | guanylate kinase, putative |
Echinococcus multilocularis | EmuJ_001029200 | guanylate kinase |
Giardia lamblia | GL50803_7203 | Guanylate kinase |
Homo sapiens | ENSG00000143774 | guanylate kinase 1 |
Leishmania braziliensis | LbrM.33.1290 | guanylate kinase, putative |
Leishmania donovani | LdBPK_331150.1 | guanylate kinase, putative |
Leishmania infantum | LinJ.33.1150 | guanylate kinase, putative |
Leishmania major | LmjF.33.1090 | guanylate kinase, putative |
Leishmania mexicana | LmxM.32.1090 | guanylate kinase, putative |
Loa Loa (eye worm) | LOAG_09178 | hypothetical protein |
Mycobacterium leprae | ML0541 | Probable guanylate kinase Gmk (GMP kinase). |
Mus musculus | ENSMUSG00000020444 | guanylate kinase 1 |
Mycobacterium tuberculosis | Rv1389 | Probable guanylate kinase Gmk |
Mycobacterium ulcerans | MUL_1788 | guanylate kinase |
Neospora caninum | NCLIV_017730 | Guanylate kinase, related |
Oryza sativa | 4352344 | Os12g0515600 |
Oryza sativa | 4332674 | Os03g0320900 |
Plasmodium berghei | PBANKA_0829700 | guanylate kinase, putative |
Plasmodium falciparum | PF3D7_0928900 | guanylate kinase |
Plasmodium knowlesi | PKNH_0727200 | guanylate kinase, putative |
Plasmodium vivax | PVX_099895 | guanylate kinase, putative |
Plasmodium yoelii | PY04174 | guanylate kinase |
Saccharomyces cerevisiae | YDR454C | guanylate kinase |
Schmidtea mediterranea | mk4.009106.01 | |
Schmidtea mediterranea | mk4.000593.00 | |
Schmidtea mediterranea | mk4.000593.02 | |
Schmidtea mediterranea | mk4.009753.00 | Putative guanylate kinase |
Schmidtea mediterranea | mk4.086433.00 | Guanylate kinase |
Schmidtea mediterranea | mk4.000593.04 | |
Schmidtea mediterranea | mk4.028472.00 | |
Trypanosoma brucei gambiense | Tbg972.10.14110 | guanylate kinase, putative |
Trypanosoma brucei | Tb927.10.11700 | guanylate kinase, putative |
Trypanosoma congolense | TcIL3000_10_9920 | guanylate kinase, putative |
Trypanosoma cruzi | TcCLB.509647.70 | guanylate kinase, putative |
Toxoplasma gondii | TGME49_242730 | guanylate kinase family protein |
Theileria parva | TP02_0576 | guanylate kinase, putative |
Trichomonas vaginalis | TVAG_441520 | guanylate kinase, putative |
Trichomonas vaginalis | TVAG_344860 | discs large, putative |
Trichomonas vaginalis | TVAG_441100 | calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative |
Trichomonas vaginalis | TVAG_247110 | sap-102, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0580 | guanylate kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.11700 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.11700 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.11700 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.11700 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3648 | Escherichia coli | essential | goodall |
CELE_T03F1.8 | Caenorhabditis elegans | slow growth | wormbase |
YDR454C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0829700 | Plasmodium berghei | Slow | plasmo |
TGME49_242730 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.