Detailed view for EHI_201830

Basic information

TDR Targets ID: 801777
Entamoeba histolytica, hypothetical protein, conserved
Source Database / ID:  AmoebaDB  

pI: 9.834 | Length (AA): 289 | MW (Da): 33198 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00687   Ribosomal protein L1p/L10e family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 113 4tql (A) 51 151 13.00 0.91 0 0.525181 -0.71
61 282 1dwu (A) 1 209 14.00 0 1 0.960866 -0.28
61 274 4lq4 (A) 1 201 15.00 0 1 0.942784 -0.41
67 279 1mzp (A) 6 210 15.00 0 1 0.992724 -0.51
115 202 3l87 (A) 73 194 33.00 0.35 0.09 0.184198 1.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_128890)

Species Accession Gene Product
Arabidopsis thaliana AT3G58660   ribosomal protein L1p/L10e family protein
Arabidopsis thaliana AT2G42650   ribosomal protein L1p/L10e family protein
Arabidopsis thaliana AT1G06380   ribosomal protein L1p/L10e family
Babesia bovis BBOV_IV009670   hypothetical protein
Brugia malayi Bm1_51345   hypothetical protein
Candida albicans CaO19.124   weak similarity to S. cerevisiae CIC1 (YHR052) proteasome interacting protein with a role in ribosomal biogenesis
Candida albicans CaO19.7771   weak similarity to S. cerevisiae CIC1 (YHR052) proteasome interacting protein with a role in ribosomal biogenesis
Caenorhabditis elegans CELE_F53F4.11   Protein F53F4.11
Cryptosporidium hominis Chro.70389   At2g42650/F14N22.8
Cryptosporidium parvum cgd7_3490   conserved hypothetical protein
Drosophila melanogaster Dmel_CG13096   CG13096 gene product from transcript CG13096-RB
Echinococcus granulosus EgrG_001036100   cellular senescence inhibited gene
Entamoeba histolytica EHI_201830   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001036100   cellular senescence inhibited gene
Homo sapiens ENSG00000171490   ribosomal L1 domain containing 1
Loa Loa (eye worm) LOAG_04753   hypothetical protein
Mus musculus ENSMUSG00000005846   ribosomal L1 domain containing 1
Neospora caninum NCLIV_057650   T2D23.8 protein, related
Oryza sativa 4339582   Os05g0558000
Onchocerca volvulus OVOC6924  
Saccharomyces cerevisiae YHR052W   Cic1p
Schistosoma japonicum Sjp_0210100   LRP2-binding protein, putative
Schistosoma japonicum Sjp_0056060   IPR002143,Ribosomal protein L1,domain-containing
Schistosoma mansoni Smp_181320   SEL-1 like protein
Toxoplasma gondii TGME49_314750   hypothetical protein
Theileria parva TP01_0801   hypothetical protein
Trichomonas vaginalis TVAG_202570   conserved hypothetical protein
Trichomonas vaginalis TVAG_055950   Ribosomal L1 domain-containing protein, putative

Essentiality

EHI_201830 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F53F4.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_F53F4.11 Caenorhabditis elegans larval arrest wormbase
CELE_F53F4.11 Caenorhabditis elegans larval lethal wormbase
CELE_F53F4.11 Caenorhabditis elegans slow growth wormbase
TGME49_314750 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_201830 (Entamoeba histolytica), hypothetical protein, conserved
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