pI: 5.9725 |
Length (AA): 240 |
MW (Da): 27285 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 162 | 4z2z (B) | 193 | 323 | 34.00 | 0 | 1 | 1.02033 | -0.55 |
41 | 142 | 3mws (A) | 10 | 99 | 39.00 | 0 | 0.96 | 0.728 | 0.43 |
196 | 240 | 2qsf (X) | 349 | 393 | 7.00 | 0.39 | 0.03 | 0.337 | -0.92 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128104)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G13235 | DNA damage-inducible protein 1 |
Babesia bovis | BBOV_III010190 | conserved hypothetical protein |
Brugia malayi | Bm1_32555 | UBA/TS-N domain containing protein |
Candida albicans | CaO19.7258 | similar to S. cerevisiae DNA Damage Inducible protein that binds to T- and V- snare complexes |
Caenorhabditis elegans | CELE_C01G5.6 | Protein C01G5.6 |
Cryptosporidium hominis | Chro.30259 | hypothetical protein |
Cryptosporidium parvum | cgd3_2190 | ubiquitin domain containing protein with a UBA domain at the C-terminus |
Dictyostelium discoideum | DDB_G0288187 | ubiquitin-associated domain-containing protein |
Drosophila melanogaster | Dmel_CG4420 | rings lost |
Echinococcus granulosus | EgrG_000898400 | protein ddi1 2 |
Entamoeba histolytica | EHI_095840 | retroviral aspartyl protease domain-containing protein |
Entamoeba histolytica | EHI_015550 | retroviral aspartyl protease domain-containing protein |
Echinococcus multilocularis | EmuJ_000898400 | protein ddi1 2 |
Giardia lamblia | GL50803_16228 | DNA-damage inducible protein DDI1-like |
Giardia lamblia | GL50803_7718 | DNA-damage inducible protein DDI1-like |
Homo sapiens | ENSG00000170967 | DNA-damage inducible 1 homolog 1 (S. cerevisiae) |
Homo sapiens | 84301 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) |
Leishmania braziliensis | LbrM.01.0030 | DNA-damage inducible protein DDI1-like protein |
Leishmania donovani | LdBPK_010630.1 | DNA-damage inducible protein DDI1-like protein |
Leishmania infantum | LinJ.01.0630 | DNA-damage inducible protein DDI1-like protein |
Leishmania major | LmjF.01.0610 | DNA-damage inducible protein DDI1-like protein |
Leishmania mexicana | LmxM.01.0610 | DNA-damage inducible protein DDI1-like protein |
Loa Loa (eye worm) | LOAG_09845 | UBA/TS-N domain-containing protein |
Loa Loa (eye worm) | LOAG_04248 | hypothetical protein |
Mus musculus | 68817 | DNA-damage inducible protein 2 |
Mus musculus | ENSMUSG00000047619 | DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae) |
Neospora caninum | NCLIV_044460 | DNA-damage inducible protein, putative |
Oryza sativa | 4328632 | Os02g0198600 |
Onchocerca volvulus | OVOC3056 |
|
Plasmodium berghei | PBANKA_1033200 | DNA damage-inducible protein 1, putative |
Plasmodium falciparum | PF3D7_1409300 | DNA damage-inducible protein 1, putative |
Plasmodium knowlesi | PKNH_1349100 | DNA damage-inducible protein 1, putative |
Plasmodium vivax | PVX_085985 | DNA damage-inducible protein 1, putative |
Plasmodium yoelii | PY06672 | hypothetical protein |
Saccharomyces cerevisiae | YER143W | Ddi1p |
Schistosoma japonicum | Sjp_0202880 | Protein DDI1 homolog 2, putative |
Schistosoma mansoni | Smp_063670 | hypothetical protein |
Schmidtea mediterranea | mk4.006892.00 | Protein DDI1 homolog 2 |
Schmidtea mediterranea | mk4.002510.04 | Protein DDI1 homolog 2 |
Schmidtea mediterranea | mk4.018112.01 | Protein DDI1 homolog 2 |
Trypanosoma brucei gambiense | Tbg972.9.2320 | DNA-damage inducible protein DDI1-like protein, putative |
Trypanosoma brucei | Tb927.9.4390 | DNA-damage inducible protein DDI1-like protein |
Trypanosoma congolense | TcIL3000_9_1440 | DNA-damage inducible protein DDI1-like protein |
Trypanosoma cruzi | TcCLB.511585.40 | DNA-damage inducible protein DDI1-like protein, putative |
Trypanosoma cruzi | TcCLB.510155.40 | DNA-damage inducible protein DDI1-like protein, putative |
Toxoplasma gondii | TGME49_304680 | ubiquitin family protein |
Theileria parva | TP02_0129 | hypothetical protein |
Trichomonas vaginalis | TVAG_459080 | Clan AA, family A2, retrotansposon aspartic peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.2990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.2990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.2990 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.2990 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1033200 | Plasmodium berghei | Essential | plasmo |
TGME49_304680 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Human immunodeficiency virus | HIV-1 protease | 99 aa | 31.4% | 102 aa | Compounds | References |
Human immunodeficiency virus 1 | Protease | 99 aa | 32.4% | 102 aa | Compounds | References |
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 protease | 99 aa | 31.1% | 103 aa | Compounds | References |