Detailed view for EHI_131660

Basic information

TDR Targets ID: 803070
Entamoeba histolytica, protein kinase domain containing protein
Source Database / ID:  AmoebaDB  

pI: 5.3583 | Length (AA): 405 | MW (Da): 46786 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 394 3ndm (C) 22 394 32.00 0 1 1.1182 0.57
44 358 2r5t (A) 87 378 43.00 0 1 1.16388 -0.22
46 400 4wnk (A) 177 536 35.00 0 1 1.22854 0.01
67 348 3com (A) 42 293 29.00 0.000000000026 1 0.877396 0.13
235 323 4ff8 (A) 659 768 25.00 0.0028 0.91 0.548753 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_147179)

Species Accession Gene Product
Arabidopsis thaliana AT2G36350   protein kinase
Arabidopsis thaliana AT5G03640   protein kinase family protein
Arabidopsis thaliana AT3G52890   KCBP-interacting protein kinase
Entamoeba histolytica EHI_013170   protein kinase domain containing protein
Entamoeba histolytica EHI_131660   protein kinase domain containing protein
Oryza sativa 4352216   Os12g0480200
Schmidtea mediterranea mk4.029169.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 25.2% 310 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 36.2% 318 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.1% 318 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 29.3% 324 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.1% 312 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 29.0% 324 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 37.1% 318 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.7% 316 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0056 1 0.5
0.0088 0.4477 0.5
0.0081 1 0.5
0.0093 0.8828 0
0.0032 0.5 0.5
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0
0.0064 0.3377 0.8757
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0059 1 1
0.0069 0.3067 0.5
0.0091 1 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0008 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.3167
0.0023 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0066 0.3101 0
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.6247
0.0026 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_131660 (Entamoeba histolytica), protein kinase domain containing protein
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