Detailed view for EHI_187730

Basic information

TDR Targets ID: 803292
Entamoeba histolytica, acetyltransferase, GNAT family
Source Database / ID:  AmoebaDB  

pI: 7.5268 | Length (AA): 181 | MW (Da): 21371 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00583   Acetyltransferase (GNAT) family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 163 5hgz (A) 10 187 25.00 0 1 1.15145 -0.03
2 158 2ob0 (C) 4 155 24.00 0 1 1.1867 -0.45
3 157 4r3l (A) 11 167 23.00 0 1 1.17225 -0.48
63 135 3qki (A) 289 357 38.00 0.1 0.21 0.444515 1.45
64 131 3d8p (A) 55 134 37.00 0.05 0.47 0.567891 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_130848)

Species Accession Gene Product
Arabidopsis thaliana AT5G16800   GCN5-related N-acetyltransferase (GNAT) family protein
Arabidopsis thaliana AT3G02980   meiotic control of crossovers1 protein
Brugia malayi Bm1_47710   acetyltransferase, GNAT family protein
Caenorhabditis elegans CELE_F30F8.10   Protein F30F8.10, isoform A
Caenorhabditis elegans CELE_F54E7.9   Protein F54E7.9
Cryptosporidium hominis Chro.80236   GCN5-related N-acetyltransferase (GNAT) family
Cryptosporidium parvum cgd8_2010   span like RimI family protein amino acetyltransferase
Dictyostelium discoideum DDB_G0289581   GCN5-related N-acetyltransferase
Drosophila melanogaster Dmel_CG18177   N(alpha)-acetyltransferase 60
Echinococcus granulosus EgrG_000084400   N alpha acetyltransferase 60
Entamoeba histolytica EHI_187730   acetyltransferase, GNAT family
Echinococcus multilocularis EmuJ_000084400  
Homo sapiens ENSG00000122390   N(alpha)-acetyltransferase 60, NatF catalytic subunit
Loa Loa (eye worm) LOAG_08250   hypothetical protein
Mus musculus ENSMUSG00000005982   N(alpha)-acetyltransferase 60, NatF catalytic subunit
Oryza sativa 9269142   Os02g0694201
Schmidtea mediterranea mk4.000675.06   N-alpha-acetyltransferase 60
Schmidtea mediterranea mk4.002125.06   N-alpha-acetyltransferase 60
Trichomonas vaginalis TVAG_096140   N-terminal acetyltransferase, putative
Trichomonas vaginalis TVAG_169900   N-terminal acetyltransferase, putative
Trichomonas vaginalis TVAG_123540   N-acetyltransferase separation anxiety, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0003 0.5 0.5
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_187730 (Entamoeba histolytica), acetyltransferase, GNAT family
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