pI: 5.7571 |
Length (AA): 351 |
MW (Da): 38972 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 349 | 5kdo (B) | 2 | 339 | 56.00 | 0 | 1 | 1.71501 | -1.05 |
13 | 350 | 2pbi (B) | 16 | 353 | 44.00 | 0 | 1 | 1.58476 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Trophozoite, Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_127973)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G34460 | guanine nucleotide-binding protein subunit beta |
Brugia malayi | Bm1_54755 | Guanine nucleotide-binding protein beta subunit 1, putative |
Candida albicans | CaO19.799 | G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece |
Candida albicans | CaO19.8419 | G-beta repeat protein similar to S. cerevisiae STE4 (YOR212W) beta subunit of heterotrimeric G protein coupled to pheromone rece |
Caenorhabditis elegans | CELE_F13D12.7 | Protein GPB-1, isoform B |
Dictyostelium discoideum | DDB_G0277143 | G protein b |
Drosophila melanogaster | Dmel_CG10545 | G protein beta-subunit 13F |
Echinococcus granulosus | EgrG_000456200 | guanine nucleotide binding protein subunit beta |
Echinococcus granulosus | EgrG_000200300 | guanine nucleotide binding protein subunit |
Echinococcus granulosus | EgrG_000898100 | F box protein 36 |
Entamoeba histolytica | EHI_000240 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000898100 | F box protein 36 |
Echinococcus multilocularis | EmuJ_000200300 | guanine nucleotide binding protein subunit |
Echinococcus multilocularis | EmuJ_000456200 | guanine nucleotide binding protein subunit beta |
Homo sapiens | 59345 | guanine nucleotide binding protein (G protein), beta polypeptide 4 |
Homo sapiens | ENSG00000078369 | guanine nucleotide binding protein (G protein), beta polypeptide 1 |
Homo sapiens | ENSG00000172354 | guanine nucleotide binding protein (G protein), beta polypeptide 2 |
Loa Loa (eye worm) | LOAG_11417 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06405 | GTP-binding regulatory protein beta chain |
Mus musculus | ENSMUSG00000029713 | guanine nucleotide binding protein (G protein), beta 2 |
Mus musculus | ENSMUSG00000029064 | guanine nucleotide binding protein (G protein), beta 1 |
Mus musculus | ENSMUSG00000027669 | guanine nucleotide binding protein (G protein), beta 4 |
Oryza sativa | 4333680 | Os03g0669200 |
Saccharomyces cerevisiae | YOR212W | Ste4p |
Schistosoma japonicum | Sjp_0128220 | Guanine nucleotide-binding protein subunit beta-1, putative |
Schistosoma japonicum | Sjp_0121270 | ko:K10312 F-box protein 36, putative |
Schistosoma japonicum | Sjp_0030040 | Guanine nucleotide-binding protein subunit beta, putative |
Schistosoma japonicum | Sjp_0110650 | Guanine nucleotide-binding protein subunit beta-1, putative |
Schistosoma japonicum | Sjp_0124130 | Guanine nucleotide-binding protein subunit beta, putative |
Schistosoma japonicum | Sjp_0030060 | Guanine nucleotide-binding protein subunit beta-1, putative |
Schistosoma japonicum | Sjp_0064530 | ko:K07972 guanine nucleotide binding protein (G protein), beta, other, putative |
Schistosoma mansoni | Smp_010230.2 | guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) |
Schistosoma mansoni | Smp_063640 | G-protein beta subunit |
Schistosoma mansoni | Smp_010230.1 | guanine nucleotide-binding protein beta 1 4 (G protein beta1 4) |
Schmidtea mediterranea | mk4.004218.00 | Guanine nucleotide-binding protein subunit beta-2 |
Schmidtea mediterranea | mk4.005846.00 | F-box only protein 36 |
Schmidtea mediterranea | mk4.003090.00 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.000101.05 | |
Schmidtea mediterranea | mk4.000101.06 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.005299.03 | Guanine nucleotide-binding protein subunit beta-5 |
Schmidtea mediterranea | mk4.020317.00 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.043089.00 | F-box only protein 36 |
Schmidtea mediterranea | mk4.005653.00 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.005653.02 | |
Schmidtea mediterranea | mk4.004112.00 | Guanine nucleotide-binding protein subunit beta-5 |
Schmidtea mediterranea | mk4.005653.01 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.042824.00 | Guanine nucleotide-binding protein subunit beta-1 |
Schmidtea mediterranea | mk4.010310.00 | Guanine nucleotide-binding protein subunit beta-2 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F13D12.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F13D12.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F13D12.7 | Caenorhabditis elegans | sterile | wormbase |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | guanine nucleotide binding protein (G protein), beta polypeptide 4 | Compounds | References |