Detailed view for EHI_094090

Basic information

TDR Targets ID: 805402
Entamoeba histolytica, aldose 1-epimerase
Source Database / ID:  AmoebaDB  

pI: 5.9996 | Length (AA): 341 | MW (Da): 38754 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01263   Aldose 1-epimerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0019318   hexose metabolic process  
GO:0030246   carbohydrate binding  
GO:0016853   isomerase activity  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 341 4rnl (A) 1 338 32.00 0 1 1.3871 -0.73
1 340 1snz (A) 1 339 35.00 0 1 1.44837 -0.88
20 340 1lur (A) 1004 1326 29.00 0 1 1.34465 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_127837)

Species Accession Gene Product
Arabidopsis thaliana AT3G47800   putative aldose 1-epimerase
Arabidopsis thaliana AT3G17940   putative aldose 1-epimerase
Arabidopsis thaliana AT3G01260   aldose 1-epimerase-like prtotein
Arabidopsis thaliana AT5G15140   aldose 1-epimerase-like protein
Brugia malayi Bm1_27085   Aldose 1-epimerase family protein
Caenorhabditis elegans CELE_C01B4.6   Protein C01B4.6
Caenorhabditis elegans CELE_Y19D10A.16   Protein Y19D10A.16
Drosophila melanogaster Dmel_CG10996   CG10996 gene product from transcript CG10996-RA
Drosophila melanogaster Dmel_CG10467   CG10467 gene product from transcript CG10467-RA
Drosophila melanogaster Dmel_CG4988   CG4988 gene product from transcript CG4988-RA
Drosophila melanogaster Dmel_CG32445   CG32445 gene product from transcript CG32445-RA
Drosophila melanogaster Dmel_CG32444   CG32444 gene product from transcript CG32444-RA
Escherichia coli b0756   aldose 1-epimerase
Echinococcus granulosus EgrG_000854000   Aldose 1 epimerase
Entamoeba histolytica EHI_094090   aldose 1-epimerase
Echinococcus multilocularis EmuJ_000854000   Aldose 1 epimerase
Homo sapiens ENSG00000143891   galactose mutarotase (aldose 1-epimerase)
Leishmania braziliensis LbrM.23.0460   aldose 1-epimerase-like protein
Leishmania donovani LdBPK_351000.1   aldose 1-epimerase-like protein
Leishmania donovani LdBPK_230470.1   aldose 1-epimerase-like protein
Leishmania infantum LinJ.23.0470   aldose 1-epimerase-like protein
Leishmania major LmjF.35.0980   aldose 1-epimerase-like protein
Leishmania major LmjF.23.0430   aldose 1-epimerase-like protein
Leishmania mexicana LmxM.34.0980   aldose 1-epimerase-like protein
Leishmania mexicana LmxM.23.0430   aldose 1-epimerase-like protein
Loa Loa (eye worm) LOAG_11658   hypothetical protein
Loa Loa (eye worm) LOAG_12962   aldose 1-epimerase
Mus musculus ENSMUSG00000035473   galactose mutarotase
Mycobacterium ulcerans MUL_3204   aldose 1-epimerase
Oryza sativa 4336039   Os04g0458600
Oryza sativa 4336037   Os04g0458300
Oryza sativa 4348138   Os10g0155500
Oryza sativa 4329753   Os02g0575800
Oryza sativa 4332976   Os03g0381000
Onchocerca volvulus OVOC5874  
Saccharomyces cerevisiae YNR071C   aldose 1-epimerase superfamily protein
Saccharomyces cerevisiae YHR210C   aldose 1-epimerase superfamily protein
Schmidtea mediterranea mk4.005393.00   Aldose 1-epimerase
Trypanosoma cruzi TcCLB.509331.180   aldose 1-epimerase-like protein, putative
Trypanosoma cruzi TcCLB.504425.90   aldose 1-epimerase-like protein, putative
Trichomonas vaginalis TVAG_123260   aldose-1-epimerase, putative

Essentiality

EHI_094090 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0756 Escherichia coli non-essential goodall
CELE_C01B4.6 Caenorhabditis elegans larval arrest wormbase
CELE_Y19D10A.16 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier EHI_094090 (Entamoeba histolytica), aldose 1-epimerase
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