Detailed view for EHI_080740

Basic information

TDR Targets ID: 805413
Entamoeba histolytica, filopodin, putative
Source Database / ID:  AmoebaDB  

pI: 4.781 | Length (AA): 1356 | MW (Da): 151870 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain
PF01608   I/LWEQ domain
PF16511   N-terminal or F0 domain of Talin-head FERM

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 76 2kmc (A) 27 96 13.00 0.079 0.64 0.166572 -0.51
147 365 3g9w (A) 197 407 29.00 0 1 0.433904 -0.01
357 1218 1qgr (A) 1 871 11.00 0 1 0.663093 0.59
357 1353 1tr2 (A) 13 1040 12.00 0 1 0.776651 0.69
570 1355 4pjw (A) 83 904 14.00 0 0.77 0.511046 1.15
1001 1274 5k7v (A) 9 274 19.00 0.35 0.99 0.503465 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Trophozoite. Hon CC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_129801)

Species Accession Gene Product
Brugia malayi Bm1_56215   I/LWEQ domain containing protein
Brugia malayi Bm1_56490   Talin 1
Caenorhabditis elegans CELE_Y71G12B.11   Protein Y71G12B.11, isoform B
Dictyostelium discoideum DDB_G0290481   hypothetical protein
Dictyostelium discoideum DDB_G0287505   hypothetical protein
Drosophila melanogaster Dmel_CG6831   CG6831 gene product from transcript CG6831-RB
Echinococcus granulosus EgrG_000736000   talin
Echinococcus granulosus EgrG_001166200   talin 2
Entamoeba histolytica EHI_080740   filopodin, putative
Entamoeba histolytica EHI_167130   filopodin, putative
Echinococcus multilocularis EmuJ_001166200   talin 2
Echinococcus multilocularis EmuJ_000736000   talin
Homo sapiens ENSG00000137076   talin 1
Homo sapiens ENSG00000171914   talin 2
Loa Loa (eye worm) LOAG_04558   talin 1
Loa Loa (eye worm) LOAG_08624   hypothetical protein
Loa Loa (eye worm) LOAG_09457   Tln1 protein
Mus musculus ENSMUSG00000028465   talin 1
Mus musculus ENSMUSG00000052698   talin 2
Onchocerca volvulus OVOC336  
Schistosoma japonicum Sjp_0309470   IPR002558,I/LWEQ,domain-containing
Schistosoma japonicum Sjp_0006570   ko:K06271 talin, putative
Schistosoma japonicum Sjp_0019690   Talin-1, putative
Schistosoma japonicum Sjp_0110080   Talin-1, putative
Schistosoma japonicum Sjp_0019700   IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing
Schistosoma mansoni Smp_142630   talin 2
Schistosoma mansoni Smp_167010   talin
Schmidtea mediterranea mk4.021025.00  
Schmidtea mediterranea mk4.031543.01  
Schmidtea mediterranea mk4.003263.00   Putative talin 2
Schmidtea mediterranea mk4.002672.04  
Schmidtea mediterranea mk4.002809.04  
Schmidtea mediterranea mk4.007599.01  
Schmidtea mediterranea mk4.003263.01  
Schmidtea mediterranea mk4.002672.03  
Schmidtea mediterranea mk4.024209.01   Putative talin 2
Schmidtea mediterranea mk4.001985.05  
Schmidtea mediterranea mk4.031543.00  
Schmidtea mediterranea mk4.001985.06  
Schmidtea mediterranea mk4.002672.00  
Schmidtea mediterranea mk4.001985.04  
Schmidtea mediterranea mk4.002672.01  
Schmidtea mediterranea mk4.024209.00  

Essentiality

EHI_080740 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y71G12B.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71G12B.11 Caenorhabditis elegans larval arrest wormbase
CELE_Y71G12B.11 Caenorhabditis elegans larval lethal wormbase
CELE_Y71G12B.11 Caenorhabditis elegans slow growth wormbase
CELE_Y71G12B.11 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_080740 (Entamoeba histolytica), filopodin, putative
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