Detailed view for EHI_177610

Basic information

TDR Targets ID: 805648
Entamoeba histolytica, hypothetical protein, conserved
Source Database / ID:  AmoebaDB  

pI: 9.5346 | Length (AA): 176 | MW (Da): 20269 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01956   Integral membrane protein DUF106

Gene Ontology

Mouse over links to read term descriptions.
GO:0032469   endoplasmic reticulum calcium ion homeostasis  
GO:0030176   integral to endoplasmic reticulum membrane  
GO:0016020   membrane  
GO:0005262   calcium channel activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 73 4tql (A) 107 164 9.00 0.67 0 0.443582 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Trophozoite, Rahman HM-1 IMSS Trophozoite. Hon CC
Show/Hide expression data references
  • Hon CC Transcriptomics of virulent and avirulent strains

Orthologs

Ortholog group members (OG5_130122)

Species Accession Gene Product
Arabidopsis thaliana AT5G06660   hypothetical protein
Arabidopsis thaliana AT3G12030   hypothetical protein
Babesia bovis BBOV_IV002080   hypothetical protein
Brugia malayi Bm1_16235   hypothetical protein
Caenorhabditis elegans CELE_F22B5.10   Protein F22B5.10
Cryptosporidium hominis Chro.60186   dbj
Cryptosporidium parvum cgd6_1490   dbj
Dictyostelium discoideum DDB_G0281489   hypothetical protein
Drosophila melanogaster Dmel_CG10470   CG10470 gene product from transcript CG10470-RA
Echinococcus granulosus EgrG_000703900   protein of unknown function DUF841 eukaryotic
Entamoeba histolytica EHI_177610   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000703900   protein of unknown function DUF841, eukaryotic
Homo sapiens ENSG00000143183   transmembrane and coiled-coil domains 1
Loa Loa (eye worm) LOAG_14121   transmembrane and coiled-coil domains 1
Loa Loa (eye worm) LOAG_06225   TU37B2
Mus musculus ENSMUSG00000052428   transmembrane and coiled-coil domains 1
Neospora caninum NCLIV_068820   hypothetical protein
Oryza sativa 4333937   Os03g0721400
Onchocerca volvulus OVOC13485  
Plasmodium berghei PBANKA_1138300   conserved protein, unknown function
Plasmodium falciparum PF3D7_1362300   conserved protein, unknown function
Plasmodium knowlesi PKNH_1109000   conserved protein, unknown function
Plasmodium vivax PVX_115070   hypothetical protein, conserved
Plasmodium yoelii PY00975   Arabidopsis thaliana At5g06660/F15M7_19, putative
Schistosoma japonicum Sjp_0003090   Transmembrane and coiled-coil domains protein 1, putative
Schmidtea mediterranea mk4.001166.05   Tmco1 protein
Toxoplasma gondii TGME49_310870   integral membrane protein, putative
Theileria parva TP03_0444   hypothetical protein, conserved
Trichomonas vaginalis TVAG_070920   conserved hypothetical protein
Trichomonas vaginalis TVAG_477310   transmembrane and coiled-coil domains protein, putative

Essentiality

EHI_177610 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_310870 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EHI_177610 (Entamoeba histolytica), hypothetical protein, conserved
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