pI: 7.3651 |
Length (AA): 410 |
MW (Da): 47003 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 227 | 1r1z (A) | 52 | 272 | 24.00 | 0 | 1 | 0.90579 | -1.24 |
18 | 259 | 2dur (A) | 57 | 299 | 27.00 | 0 | 1 | 0.913644 | -0.62 |
30 | 224 | 2eig (A) | 12 | 220 | 16.00 | 0 | 0.99 | 0.53401 | -0.55 |
32 | 224 | 3a4u (A) | 67 | 261 | 28.00 | 0 | 1 | 0.848832 | -0.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Trophozoite. | Hon CC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Rahman HM-1 IMSS Trophozoite. | Hon CC |
Hon CC | Transcriptomics of virulent and avirulent strains |
Ortholog group members (OG5_128947)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_54385 | Legume-like lectin family protein |
Candida albicans | CaO19.2200 | similar to S. cerevisiae YKR044W |
Candida albicans | CaO19.9746 | similar to S. cerevisiae YKR044W |
Caenorhabditis elegans | CELE_T04G9.3 | Protein ILE-2 |
Drosophila melanogaster | Dmel_CG5510 | CG5510 gene product from transcript CG5510-RA |
Echinococcus granulosus | EgrG_000903900 | vesicular integral membrane protein vip36 |
Entamoeba histolytica | EHI_162550 | vesicular integral membrane protein VIP36, putative |
Entamoeba histolytica | EHI_104370 | Legume-like lectin family protein, membrane-bound |
Echinococcus multilocularis | EmuJ_000903900 | vesicular integral membrane protein vip36 |
Homo sapiens | ENSG00000114988 | lectin, mannose-binding 2-like |
Homo sapiens | ENSG00000169223 | lectin, mannose-binding 2 |
Leishmania braziliensis | LbrM.13.0490 | lectin, putative |
Loa Loa (eye worm) | LOAG_00673 | hypothetical protein |
Mus musculus | ENSMUSG00000021484 | lectin, mannose-binding 2 |
Mus musculus | ENSMUSG00000001143 | lectin, mannose-binding 2-like |
Schistosoma japonicum | Sjp_0216930 | ko:K10082 lectin, mannose-binding 2, putative |
Schistosoma mansoni | Smp_174580 | vesicular integral-membrane protein vip36 (mannose-binding lectin 2)-related |
Schmidtea mediterranea | mk4.005415.02 | |
Schmidtea mediterranea | mk4.010279.03 | |
Trypanosoma cruzi | TcCLB.506177.20 | lectin, putative |
Trypanosoma cruzi | TcCLB.506239.30 | lectin, putative |
Trichomonas vaginalis | TVAG_371590 | Submandibular gland secretory Glx-rich protein CA precursor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_T04G9.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.