pI: 10.1947 |
Length (AA): 173 |
MW (Da): 19736 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 172 | 4xxb (A) | 13 | 175 | 62.00 | 0 | 1 | 1.6435 | -0.89 |
14 | 167 | 5aff (C) | 15 | 167 | 65.00 | 0 | 1 | 1.35047 | -0.28 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126688)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G42740 | 60S ribosomal protein L16A |
Arabidopsis thaliana | AT5G45775 | 60S ribosomal protein L11-2 |
Arabidopsis thaliana | AT4G18730 | 60S ribosomal protein L11-2 |
Arabidopsis thaliana | AT3G58700 | 60S ribosomal protein L11-2 |
Arabidopsis thaliana | AT4G01310 | 50S ribosomal protein L5 |
Babesia bovis | BBOV_IV005460 | 60S ribosomal protein L11, putative |
Brugia malayi | Bm1_04440 | 60S ribosomal protein L11 |
Candida albicans | CaO19.2214 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL7 (YDR237W) large subunit protein L7 (E. coli L5) |
Candida albicans | CaO19.9759 | likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL7 (YDR237W) large subunit protein L7 (E. coli L5) |
Candida albicans | CaO19.2232 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL11A (YPR102C) and RPL11B (YGR085C) large subunit protein L11 |
Candida albicans | CaO19.9774 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL11A (YPR102C) and RPL11B (YGR085C) large subunit protein L11 |
Caenorhabditis elegans | CELE_F07D10.1 | Protein RPL-11.2 |
Caenorhabditis elegans | CELE_T22F3.4 | Protein RPL-11.1 |
Cryptosporidium hominis | Chro.60255 | ribosomal protein L11 |
Cryptosporidium parvum | cgd6_2170 | 60S ribosomal protein L11 |
Chlamydia trachomatis | CT_516 | 50S ribosomal protein L5 |
Dictyostelium discoideum | DDB_G0279189 | S60 ribosomal protein L11 |
Drosophila melanogaster | Dmel_CG7726 | Ribosomal protein L11 |
Escherichia coli | b3308 | 50S ribosomal subunit protein L5 |
Echinococcus granulosus | EgrG_000177700 | ribosomal protein L11 |
Entamoeba histolytica | EHI_038580 | ribosomal protein L11, putative |
Entamoeba histolytica | EHI_199970 | ribosomal protein L11, putative |
Entamoeba histolytica | EHI_124300 | ribosomal protein L11, putative |
Entamoeba histolytica | EHI_040660 | ribosomal protein L11, putative |
Echinococcus multilocularis | EmuJ_000177700 | ribosomal protein L11 |
Giardia lamblia | GL50803_5593 | Ribosomal protein L11 |
Homo sapiens | ENSG00000142676 | ribosomal protein L11 |
Leishmania braziliensis | LbrM.22.0030 | 60S ribosomal protein L11 (L5, L16) |
Leishmania braziliensis | LbrM.04.0520 | 60S ribosomal protein L11 (L5, L16) |
Leishmania donovani | LdBPK_220004.1 | 60S ribosomal protein L11 (L5, L16) |
Leishmania infantum | LinJ.04.0460 | 60S ribosomal protein L11 (L5, L16) |
Leishmania major | LmjF.22.0030 | 60S ribosomal protein L11 (L5, L16) |
Leishmania major | LmjF.04.0470 | 60S ribosomal protein L11 (L5, L16) |
Leishmania mexicana | LmxM.04.0470 | 60S ribosomal protein L11 (L5, L16) |
Loa Loa (eye worm) | LOAG_03308 | 60S ribosomal protein L11 |
Mycobacterium leprae | ML1847c | PROBABLE 50S RIBOSOMAL PROTEIN L5 RPLE |
Mus musculus | ENSMUSG00000059291 | ribosomal protein L11 |
Mus musculus | 100041864 | predicted gene 3552 |
Mus musculus | 102641328 | 60S ribosomal protein L11-like |
Mus musculus | 328825 | predicted gene 5093 |
Mycobacterium tuberculosis | Rv0716 | 50S ribosomal protein L5 RplE |
Mycobacterium ulcerans | MUL_0806 | 50S ribosomal protein L5 |
Neospora caninum | NCLIV_053950 | hypothetical protein |
Oryza sativa | 4341262 | Os06g0550000 |
Oryza sativa | 4327087 | Os01g0205500 |
Oryza sativa | 4331459 | Os03g0125000 |
Oryza sativa | 4328826 | Os02g0235600 |
Oryza sativa | 4338077 | Os05g0207300 |
Onchocerca volvulus | OVOC2085 | 60S ribosomal protein L11 homolog |
Plasmodium berghei | PBANKA_0617100 | 60S ribosomal protein L11a, putative |
Plasmodium falciparum | PF3D7_0719600 | 60S ribosomal protein L11a, putative |
Plasmodium knowlesi | PKNH_0315000 | 60S ribosomal protein L11a, putative |
Plasmodium vivax | PVX_096340 | 60S ribosomal protein L11, putative |
Plasmodium yoelii | PY02461 | ribosomal protein L11-like |
Saccharomyces cerevisiae | YPR102C | ribosomal 60S subunit protein L11A |
Saccharomyces cerevisiae | YGR085C | ribosomal 60S subunit protein L11B |
Saccharomyces cerevisiae | YDR237W | mitochondrial 54S ribosomal protein YmL7/YmL5 |
Schistosoma japonicum | Sjp_0203190 | ko:K02868 large subunit ribosomal protein L11e, putative |
Schistosoma mansoni | Smp_050940.2 | 60S ribosomal protein L11 |
Schistosoma mansoni | Smp_050940.1 | 60S ribosomal protein L11 |
Schmidtea mediterranea | mk4.011602.01 | 60S ribosomal protein L11 |
Schmidtea mediterranea | mk4.091311.02 | |
Schmidtea mediterranea | mk4.005970.03 | |
Trypanosoma brucei gambiense | Tbg972.9.4150 | 60S ribosomal protein L11, putative |
Trypanosoma brucei gambiense | Tbg972.9.4140 | 60S ribosomal protein L11, putative |
Trypanosoma brucei | Tb927.9.7590 | 60S ribosomal protein L11, putative |
Trypanosoma congolense | TcIL3000_0_18940 | 60S ribosomal protein L11, putative |
Trypanosoma congolense | TcIL3000_0_18950 | 60S ribosomal protein L11, putative |
Trypanosoma cruzi | TcCLB.508197.10 | 60S ribosomal protein L11, putative |
Trypanosoma cruzi | TcCLB.508197.39 | 60S ribosomal protein L11, putative |
Toxoplasma gondii | TGME49_309820 | ribosomal protein RPL11 |
Treponema pallidum | TP0201 | 50S ribosomal protein L5 |
Theileria parva | TP01_0352 | 60S ribosomal protein L11a, putative |
Trichomonas vaginalis | TVAG_343970 | 50S ribosomal protein L5p, putative |
Trichomonas vaginalis | TVAG_092870 | 60S ribosomal protein L11, putative |
Trichomonas vaginalis | TVAG_044560 | 50S ribosomal protein L5p, putative |
Trichomonas vaginalis | TVAG_046840 | 50S ribosomal protein L5p, putative |
Trichomonas vaginalis | TVAG_194850 | 60S ribosomal protein L11, putative |
Trichomonas vaginalis | TVAG_271230 | 60S ribosomal protein L11, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0329 | 50S ribosomal protein L5 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu728 | Mycobacterium tuberculosis | essential | nmpdr |
b3308 | Escherichia coli | essential | goodall |
CELE_T22F3.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T22F3.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T22F3.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T22F3.4 | Caenorhabditis elegans | sterile | wormbase |
CELE_F07D10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F07D10.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F07D10.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F07D10.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F07D10.1 | Caenorhabditis elegans | sterile | wormbase |
TGME49_309820 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.