pI: 4.9771 |
Length (AA): 342 |
MW (Da): 38835 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
23 | 321 | 3mes (A) | 66 | 416 | 22.00 | 0.00015 | 1 | 1.02427 | -0.1 |
37 | 313 | 2qg7 (A) | 117 | 458 | 23.00 | 0 | 1 | 1.08314 | -0.49 |
194 | 285 | 3c5i (A) | 216 | 326 | 40.00 | 0.0000069 | 0.27 | 0.258006 | 1.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127649)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G26830 | protein embryo defective 1187 |
Babesia bovis | BBOV_IV008320 | choline/ethanolamine kinase, putative |
Babesia bovis | BBOV_IV008310 | choline/ethanolamine kinase, putative |
Brugia malayi | Bm1_37000 | Choline/ethanolamine kinase family protein |
Candida albicans | CaO19.6912 | similar to ethanolamine kinase |
Candida albicans | CaO19_6912 | hypothetical protein |
Caenorhabditis elegans | CELE_T27A10.3 | Protein CKC-1, isoform B |
Cryptosporidium hominis | Chro.50319 | choline/ethanolamine kinase |
Cryptosporidium parvum | cgd5_720 | choline/ethanolamine kinase family protein |
Dictyostelium discoideum | DDB_G0274955 | ethanolamine kinase A |
Dictyostelium discoideum | DDB_G0275265 | ethanolamine kinase B |
Drosophila melanogaster | Dmel_CG3525 | easily shocked |
Echinococcus granulosus | EgrG_000360100 | ethanolamine kinase 2 |
Entamoeba histolytica | EHI_152340 | choline/ethanolamine kinase, putative |
Entamoeba histolytica | EHI_148580 | choline/ethanolamine kinase, putative |
Echinococcus multilocularis | EmuJ_000360100 | ethanolamine kinase 2 |
Giardia lamblia | GL50803_4596 | Ethanolamine kinase, putative |
Homo sapiens | ENSG00000143845 | ethanolamine kinase 2 |
Homo sapiens | ENSG00000139163 | ethanolamine kinase 1 |
Leishmania braziliensis | LbrM.27.1560 | ethanolamine kinase, putative |
Leishmania donovani | LdBPK_271330.1 | ethanolamine kinase, putative |
Leishmania infantum | LinJ.27.1330 | ethanolamine kinase, putative |
Leishmania major | LmjF.27.1420 | choline kinase |
Leishmania mexicana | LmxM.27.1420 | choline/ethanolamine kinase, putative |
Loa Loa (eye worm) | LOAG_08101 | choline/ethanolamine kinase |
Loa Loa (eye worm) | LOAG_12651 | hypothetical protein |
Mus musculus | ENSMUSG00000070644 | ethanolamine kinase 2 |
Mus musculus | ENSMUSG00000030275 | ethanolamine kinase 1 |
Neospora caninum | NCLIV_044730 | GmCK2p (EC 2.7.1.32), related |
Oryza sativa | 4347160 | Os09g0438400 |
Plasmodium berghei | PBANKA_0923700 | ethanolamine kinase, putative |
Plasmodium falciparum | PF3D7_1124600 | ethanolamine kinase |
Plasmodium knowlesi | PKNH_0922400 | ethanolamine kinase, putative |
Plasmodium vivax | PVX_091845 | ethanolamine kinase, putative |
Plasmodium yoelii | PY00818 | Choline/ethanolamine kinase, putative |
Schistosoma japonicum | Sjp_0016450 | Ethanolamine kinase 1, putative |
Schistosoma japonicum | Sjp_0202810 | ko:K00894 ethanolamine kinase [EC2.7.1.82], putative |
Schistosoma mansoni | Smp_015050 | choline kinase |
Schistosoma mansoni | Smp_015030 | choline/ethanolamine kinase |
Schmidtea mediterranea | mk4.000069.07 | |
Schmidtea mediterranea | mk4.000069.09 | |
Trypanosoma brucei gambiense | Tbg972.11.2280 | choline/ethanolamine kinase, putative |
Trypanosoma brucei | Tb927.11.2090 | choline kinase |
Trypanosoma cruzi | TcCLB.508355.190 | choline kinase |
Toxoplasma gondii | TGME49_306540 | phosphotransferase enzyme family protein |
Theileria parva | TP01_0942 | choline kinase, putative |
Trichomonas vaginalis | TVAG_333190 | choline/ethanolamine kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.18.0017 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.18.0017 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.18.0017 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.18.0017 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0923700 | Plasmodium berghei | Slow | plasmo |
TGME49_306540 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.