Detailed view for GL50803_33685

Basic information

TDR Targets ID: 811766
Giardia lamblia, Hypothetical protein
Source Database / ID:  GiardiaDB  

pI: 6.9433 | Length (AA): 1075 | MW (Da): 115901 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 56 4jw2 (A) 34 81 20.00 0.12 0.08 0.323991 -1.27
19 153 4d4e (A) 94 225 14.00 0.00016 0.17 0.289781 -0.71
111 441 3ifq (A) 272 649 24.00 0.22 0.99 0.303707 0.43
239 982 2qmr (B) 64 885 12.00 0 1 0.775593 0.3
328 441 4ev8 (A) 535 659 22.00 0 0.77 0.527746 -1.54
371 437 5ewp (A) 71 129 37.00 0.27 0.13 0.235126 0.7
530 656 1ee4 (A) 228 353 29.00 0.2 1 0.54794 -0.9
955 1008 2xsd (C) 351 397 13.00 0.0027 0.01 0.128433 -1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131342)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG5155   CG5155 gene product from transcript CG5155-RA
Echinococcus granulosus EgrG_000132600   armadillo repeat containing protein 4
Echinococcus granulosus EgrG_000839200   armadillo repeat containing protein 4
Echinococcus multilocularis EmuJ_000132600   armadillo repeat containing protein 4
Echinococcus multilocularis EmuJ_000839200   armadillo repeat containing protein 4
Giardia lamblia GL50803_33685   Hypothetical protein
Homo sapiens ENSG00000169126   armadillo repeat containing 4
Leishmania braziliensis LbrM.32.0200   hypothetical protein, conserved
Leishmania donovani LdBPK_320140.1   Flagellum attachment zone protein 9
Leishmania infantum LinJ.32.0140   hypothetical protein, conserved
Leishmania major LmjF.32.0140   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0140   hypothetical protein, conserved
Mus musculus ENSMUSG00000061802   armadillo repeat containing 4
Schistosoma japonicum Sjp_0119530   Armadillo repeat-containing protein 4, putative
Schistosoma japonicum Sjp_0017210   Armadillo repeat-containing protein 4, putative
Schistosoma japonicum Sjp_0017190   Armadillo repeat-containing protein 4, putative
Schistosoma mansoni Smp_176850   armc4
Schmidtea mediterranea mk4.016512.00  
Schmidtea mediterranea mk4.002419.05  
Schmidtea mediterranea mk4.001264.00   Putative armc4
Trypanosoma brucei gambiense Tbg972.10.17400   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14320   Flagellum attachment zone protein 9
Trypanosoma congolense TcIL3000_10_12190   Flagellum attachment zone protein 9
Trypanosoma cruzi TcCLB.506527.4   Armadillo/beta-catenin-like repeat, putative
Trypanosoma cruzi TcCLB.511283.160   Flagellum attachment zone protein 9
Trichomonas vaginalis TVAG_434000   armc4, putative
Trichomonas vaginalis TVAG_253760   armc4, putative
Trichomonas vaginalis TVAG_322590   armc4, putative

Essentiality

GL50803_33685 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14320 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14320 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14320 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.14320 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_33685 (Giardia lamblia), Hypothetical protein
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