Detailed view for GL50803_3256

Basic information

TDR Targets ID: 812156
Giardia lamblia, EH domain binding protein epsin 2
Source Database / ID:  GiardiaDB  

pI: 8.0639 | Length (AA): 405 | MW (Da): 45266 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01417   ENTH domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 162 1h0a (A) 9 157 30.00 0 1 0.89567 -2
21 144 5loz (A) 0 137 26.00 0 1 0.867473 -2.72
22 152 1xgw (A) 34 164 33.00 0 1 0.965357 -2.28
289 349 4fe8 (C) 354 410 47.00 0.027 0.07 0.427517 1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128219)

Species Accession Gene Product
Arabidopsis thaliana AT5G11710   clathrin interactor EPSIN 1
Arabidopsis thaliana AT2G43160   putative clathrin interactor EPSIN 2
Arabidopsis thaliana AT3G59290   clathrin interactor EPSIN 3
Babesia bovis BBOV_I002870   conserved hypothetical protein
Brugia malayi Bm1_38600   ENTH domain containing protein
Candida albicans CaO19.1553   contains epsin-like N terminal domain similar to S. pombe SPCC794.11c and to S. cerevisiae ENT3 (YJR125C) clathrin vesicle coat
Candida albicans CaO19.9127   contains epsin-like N terminal domain similar to S. pombe SPCC794.11c and to S. cerevisiae ENT3 (YJR125C) clathrin vesicle coat
Caenorhabditis elegans CELE_C34E11.1   Protein RSD-3
Cryptosporidium hominis Chro.80222   hypothetical protein
Cryptosporidium parvum cgd8_1910   epsin like ENTH/VHS domain involved in endocytosis/vesicular trafficking
Dictyostelium discoideum DDB_G0291512   hypothetical protein
Drosophila melanogaster Dmel_CG42250   liquid facets-Related
Echinococcus granulosus EgrG_000113400   clathrin interactor 1
Entamoeba histolytica EHI_176980   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000113400   clathrin interactor 1
Giardia lamblia GL50803_3256   EH domain binding protein epsin 2
Homo sapiens ENSG00000113282   clathrin interactor 1
Loa Loa (eye worm) LOAG_09733   hypothetical protein
Mus musculus ENSMUSG00000006169   clathrin interactor 1
Neospora caninum NCLIV_051420   KLLA0B04587p, related
Oryza sativa 9268417   Os02g0806600
Oryza sativa 4327195   Os01g0738600
Oryza sativa 4336871   Os04g0599900
Plasmodium berghei PBANKA_1458900   epsin, putative
Plasmodium falciparum PF3D7_1245800   epsin, putative
Plasmodium knowlesi PKNH_1465400   epsin, putative
Plasmodium vivax PVX_101180   epsin, putative
Plasmodium yoelii PY07827   vitellogenin
Saccharomyces cerevisiae YJR125C   Ent3p
Schistosoma japonicum Sjp_0064420   Clathrin interactor 1, putative
Schistosoma mansoni Smp_140330   epsin 4/enthoprotin
Schmidtea mediterranea mk4.000282.02   Clathrin interactor 1
Schmidtea mediterranea mk4.011477.01  
Trypanosoma cruzi TcCLB.506925.70   epsin, putative
Toxoplasma gondii TGME49_214180   ENTH domain-containing protein
Theileria parva TP01_0558   hypothetical protein
Trichomonas vaginalis TVAG_355610   epsin 4/enthoprotin, putative

Essentiality

GL50803_3256 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_214180 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_3256 (Giardia lamblia), EH domain binding protein epsin 2
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