pI: 5.1031 |
Length (AA): 1871 |
MW (Da): 206954 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 510 | 1bpo (A) | 1 | 487 | 28.00 | 0 | 1 | 0.594082 | -0.23 |
1137 | 1240 | 2wqh (A) | 8 | 108 | 7.00 | 0.00042 | 0.33 | 0.145685 | -0.64 |
1243 | 1867 | 3lvg (A) | 1080 | 1629 | 30.00 | 0 | 1 | 0.418546 | 1.5 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127480)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G08530 | Clathrin, heavy chain |
Arabidopsis thaliana | AT3G11130 | Clathrin, heavy chain |
Babesia bovis | BBOV_IV001820 | clathrin heavy chain |
Brugia malayi | Bm1_21545 | Probable clathrin heavy chain |
Candida albicans | CaO19.3496 | presumed vesical coat protein (clathrin heavy chain) |
Candida albicans | CaO19.10990 | presumed vesical coat protein (clathrin heavy chain) |
Caenorhabditis elegans | CELE_T20G5.1 | Protein CHC-1 |
Cryptosporidium hominis | Chro.80150 | clathrin, heavy polypeptide (Hc) |
Cryptosporidium parvum | cgd8_1270 | clathrin heavy chain |
Dictyostelium discoideum | DDB_G0277221 | clathrin heavy chain |
Drosophila melanogaster | Dmel_CG9012 | Clathrin heavy chain |
Echinococcus granulosus | EgrG_000122200 | clathrin heavy chain |
Entamoeba histolytica | EHI_201510 | clathrin heavy chain, putative |
Entamoeba histolytica | EHI_201710 | clathrin heavy chain, putative |
Echinococcus multilocularis | EmuJ_000122200 | clathrin heavy chain |
Giardia lamblia | GL50803_102108 | Clathrin heavy chain |
Homo sapiens | ENSG00000141367 | clathrin, heavy chain (Hc) |
Homo sapiens | ENSG00000070371 | clathrin, heavy chain-like 1 |
Leishmania braziliensis | LbrM.35.1780 | clathrin heavy chain, putative |
Leishmania donovani | LdBPK_361700.1 | clathrin heavy chain, putative |
Leishmania infantum | LinJ.36.1700 | clathrin heavy chain, putative |
Leishmania major | LmjF.36.1630 | clathrin heavy chain, putative |
Leishmania mexicana | LmxM.36.1630 | clathrin heavy chain, putative |
Loa Loa (eye worm) | LOAG_00018 | clathrin |
Mus musculus | ENSMUSG00000047126 | clathrin, heavy polypeptide (Hc) |
Neospora caninum | NCLIV_042820 | cDNA FLJ58099, highly similar to Homo sapiens clathrin, heavy polypeptide-like 1 (CLTCL1), transcript variant 1, mRNA, related |
Oryza sativa | 4351255 | Os12g0104800 |
Oryza sativa | 4349546 | Os11g0104900 |
Plasmodium berghei | PBANKA_1434700 | clathrin heavy chain, putative |
Plasmodium falciparum | PF3D7_1219100 | clathrin heavy chain, putative |
Plasmodium knowlesi | PKNH_1438700 | clathrin heavy chain, putative |
Plasmodium vivax | PVX_123620 | clathrin heavy chain, putative |
Plasmodium yoelii | PY01854 | putative clathrin heavy chain |
Saccharomyces cerevisiae | YGL206C | clathrin heavy chain |
Schistosoma japonicum | Sjp_0040780 | Clathrin heavy chain 1, putative |
Schistosoma japonicum | Sjp_0217180 | Clathrin heavy chain 1, putative |
Schistosoma japonicum | Sjp_0040760 | ko:K04646 clathrin, heavy polypeptide, putative |
Schistosoma mansoni | Smp_154420.2 | clathrin heavy chain |
Schistosoma mansoni | Smp_154420.1 | clathrin heavy chain |
Schmidtea mediterranea | mk4.003441.00 | Probable clathrin heavy chain 1 |
Trypanosoma brucei gambiense | Tbg972.10.7400 | clathrin heavy chain, putative |
Trypanosoma brucei | Tb927.10.6050 | clathrin heavy chain |
Trypanosoma brucei | Tb11.v5.0198 | clathrin heavy chain, putative |
Trypanosoma brucei | Tb11.v5.0197 | clathrin heavy chain, putative |
Trypanosoma congolense | TcIL3000_10_5100 | clathrin heavy chain, putative |
Trypanosoma cruzi | TcCLB.481435.9 | clathrin heavy chain, putative |
Trypanosoma cruzi | TcCLB.506167.50 | clathrin heavy chain, putative |
Trypanosoma cruzi | TcCLB.507785.10 | clathrin heavy chain, putative |
Toxoplasma gondii | TGME49_290950 | clathrin heavy chain, putative |
Theileria parva | TP03_0480 | clathrin heavy chain, putative |
Trichomonas vaginalis | TVAG_516070 | clathrin heavy chain, putative |
Trichomonas vaginalis | TVAG_558650 | clathrin heavy chain, putative |
Trichomonas vaginalis | TVAG_502180 | clathrin heavy chain, putative |
Trichomonas vaginalis | TVAG_532880 | clathrin heavy chain, putative |
Trichomonas vaginalis | TVAG_369020 | clathrin heavy chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6050 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6050 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6050 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.6050 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T20G5.1 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_T20G5.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_T20G5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T20G5.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T20G5.1 | Caenorhabditis elegans | sterile | wormbase |
YGL206C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1434700 | Plasmodium berghei | Essential | plasmo |
TGME49_290950 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | clathrin, heavy chain (Hc) | Compounds | References |