pI: 5.2923 |
Length (AA): 326 |
MW (Da): 35036 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 117 | 1zav (A) | 3 | 118 | 17.00 | 0 | 0.98 | 0.489856 | -0.38 |
11 | 215 | 3jsy (A) | 11 | 220 | 30.00 | 0 | 1 | 0.986334 | -0.12 |
254 | 310 | 1rqu (A) | 8 | 62 | 44.00 | 0.25 | 0.02 | 0.392447 | 1.86 |
274 | 313 | 4beh (B) | 277 | 315 | 36.00 | 0.00036 | 0.01 | 0.168899 | 2.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127051)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G09200 | 60S acidic ribosomal protein P0-2 |
Arabidopsis thaliana | AT2G40010 | 60S acidic ribosomal protein P0-1 |
Arabidopsis thaliana | AT3G11250 | 60S acidic ribosomal protein P0-3 |
Babesia bovis | BBOV_IV004540 | phosphoriboprotein P0 |
Brugia malayi | Bm1_31485 | 60S acidic ribosomal protein P0 |
Candida albicans | CaO19.7015 | likely cytosolic ribosomal acidic protein similar to S. cerevisiae RPP0 (YLR340W) large subunit acidic protein P0 |
Candida albicans | CaO19_7015 | hypothetical protein |
Caenorhabditis elegans | CELE_F25H2.10 | Protein RLA-0 |
Cryptosporidium hominis | Chro.40257 | ribosomal P protein |
Cryptosporidium parvum | cgd4_2260 | ribosomal protein PO like protein of the L10 family |
Dictyostelium discoideum | DDB_G0286501 | 60S acidic ribosomal protein P0 |
Drosophila melanogaster | Dmel_CG7490 | Ribosomal protein LP0 |
Echinococcus granulosus | EgrG_000622800 | deoxyribonuclease |
Entamoeba histolytica | EHI_175460 | 60S acidic ribosomal protein P0, putative |
Entamoeba histolytica | EHI_148850 | 60S acidic ribosomal protein P0, putative |
Entamoeba histolytica | EHI_177630 | 60S acidic ribosomal protein P0, putative |
Entamoeba histolytica | EHI_090400 | 60S acidic ribosomal protein P0, putative |
Echinococcus multilocularis | EmuJ_000622800 | deoxyribonuclease |
Giardia lamblia | GL50803_17054 | Acidic ribosomal protein P0 |
Homo sapiens | ENSG00000089157 | ribosomal protein, large, P0 |
Leishmania braziliensis | LbrM.27.1530 | 60S acidic ribosomal subunit protein, putative |
Leishmania braziliensis | LbrM.27.1520 | 60S acidic ribosomal subunit protein, putative |
Leishmania donovani | LdBPK_072480.1 | 60S acidic ribosomal protein P0, putative |
Leishmania infantum | LinJ.27.1300 | 60S acidic ribosomal subunit protein, putative |
Leishmania infantum | LinJ.27.2480 | 60S acidic ribosomal subunit protein |
Leishmania major | LmjF.27.1390 | 60S acidic ribosomal subunit protein, putative |
Leishmania major | LmjF.27.1380 | 60S acidic ribosomal subunit protein, putative |
Leishmania mexicana | LmxM.27.1390 | |
Leishmania mexicana | LmxM.27.1380 | 60S acidic ribosomal subunit protein, putative |
Loa Loa (eye worm) | LOAG_00384 | 60S acidic ribosomal protein P0 |
Mus musculus | ENSMUSG00000067274 | ribosomal protein, large, P0 |
Neospora caninum | NCLIV_061830 | 60S acidic ribosomal protein P0 |
Oryza sativa | 9266027 | Os11g0135300 |
Oryza sativa | 9270965 | Os12g0133050 |
Oryza sativa | 4344590 | Os08g0130500 |
Plasmodium berghei | PBANKA_0918000 | 60S acidic ribosomal protein P0, putative |
Plasmodium falciparum | PF3D7_1130200 | 60S ribosomal protein P0 |
Plasmodium knowlesi | PKNH_0928100 | 60S acidic ribosomal protein P0, putative |
Plasmodium vivax | PVX_092120 | 60S acidic ribosomal protein P0, putative |
Plasmodium yoelii | PY00659 | Ribosomal protein L10, putative |
Saccharomyces cerevisiae | YLR340W | ribosomal protein P0 |
Schistosoma japonicum | Sjp_0116280 | ko:K02941 large subunit ribosomal protein LP0, putative |
Schistosoma mansoni | Smp_009690.2 | 60S ribosomal protein P0 |
Schistosoma mansoni | Smp_009690.1 | 60S ribosomal protein P0 |
Schmidtea mediterranea | mk4.000621.06 | 60S acidic ribosomal protein P0 |
Schmidtea mediterranea | mk4.000002.04 | 60S acidic ribosomal protein P0 |
Trypanosoma brucei gambiense | Tbg972.11.2240 | 60S acidic ribosomal subunit protein, putative |
Trypanosoma brucei gambiense | Tbg972.11.2250 | 60S acidic ribosomal subunit protein, putative |
Trypanosoma brucei | Tb927.11.2060 | 60S acidic ribosomal protein P0, putative |
Trypanosoma brucei | Tb927.11.2050 | 60S acidic ribosomal protein P0, putative |
Trypanosoma congolense | TcIL3000.11.1760 | 60S acidic ribosomal protein P0, putative |
Trypanosoma congolense | TcIL3000.11.1750 | 60S acidic ribosomal protein P0, putative |
Trypanosoma cruzi | TcCLB.508355.260 | 60S acidic ribosomal protein P0, putative |
Trypanosoma cruzi | TcCLB.508355.250 | 60S acidic ribosomal protein P0, putative |
Toxoplasma gondii | TGME49_218410 | ribosomal protein RPP0 |
Theileria parva | TP01_0294 | 60S acidic ribosomal protein, P0, putative |
Trichomonas vaginalis | TVAG_191640 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_344700 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_365810 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_051160 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_006370 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_097860 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_191260 | 60S acidic ribosomal protein P0, putative |
Trichomonas vaginalis | TVAG_158130 | 60S acidic ribosomal protein P0, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F25H2.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F25H2.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F25H2.10 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F25H2.10 | Caenorhabditis elegans | sterile | wormbase |
YLR340W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_218410 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.