Detailed view for GL50803_10570

Basic information

TDR Targets ID: 814566
Giardia lamblia, FKBP-type peptidyl-prolyl cis-trans isomerase
Source Database / ID:  GiardiaDB  

pI: 6.8785 | Length (AA): 354 | MW (Da): 38873 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00254   FKBP-type peptidyl-prolyl cis-trans isomerase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
179 353 4ggq (D) 0 113 33.00 0 1 0.91555 -0.42
224 350 4ggq (D) 0 110 45.00 0 1 0.972457 -1.12
248 353 1u79 (A) 13 128 42.00 0 1 0.779635 -1.12
248 353 2ppn (A) 1 106 39.00 0 1 0.864635 -1.35

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129720)

Species Accession Gene Product
Arabidopsis thaliana AT4G25340   peptidyl-prolyl cis-trans isomerase FKBP53
Arabidopsis thaliana AT3G12340   FKBP-like peptidyl-prolyl cis-trans isomerase family protein
Candida albicans CaO19.1030   FKBP-type peptidylprolyl cis/trans isomerase similar to S. cerevisiae FPR3 (YML074C) nucleolar proline rotamase
Candida albicans CaO19.8632   FKBP-type peptidylprolyl cis/trans isomerase similar to S. cerevisiae FPR3 (YML074C) nucleolar proline rotamase
Cryptosporidium hominis Chro.70034   immunophilin/FKBP-type peptidyl-prolyl cis-trans isomerase
Cryptosporidium parvum cgd7_210   fkbp
Dictyostelium discoideum DDB_G0285357   FKBP-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG6226   FK506-binding protein 1
Escherichia coli b3347   FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase)
Giardia lamblia GL50803_10570   FKBP-type peptidyl-prolyl cis-trans isomerase
Neospora caninum NCLIV_014540   hypothetical protein
Oryza sativa 4335968   Os04g0446500
Saccharomyces cerevisiae YLR449W   peptidylprolyl isomerase FPR4
Saccharomyces cerevisiae YML074C   peptidylprolyl isomerase FPR3
Toxoplasma gondii TGME49_285850   peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein

Essentiality

GL50803_10570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3347 Escherichia coli non-essential goodall
TGME49_285850 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Gallus gallus FK506 binding protein 12 108 aa 37.1% 105 aa Compounds References
Rattus norvegicus FK506-binding protein 1A 108 aa 41.0% 105 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier GL50803_10570 (Giardia lamblia), FKBP-type peptidyl-prolyl cis-trans isomerase
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