pI: 8.1146 |
Length (AA): 363 |
MW (Da): 40035 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 329 | 3mmy (A) | 37 | 344 | 28.00 | 0 | 1 | 1.10944 | 0.03 |
11 | 81 | 1nr0 (A) | 535 | 604 | 33.00 | 0 | 1 | 0.686192 | -0.92 |
12 | 50 | 1vyh (C) | 108 | 146 | 28.00 | 0 | 0.73 | 0.504038 | -0.61 |
23 | 78 | 1pgu (A) | 552 | 604 | 34.00 | 0.78 | 0.77 | 0.54017 | -0.28 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129740)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G19590 | cell cycle arrest protein BUB3 |
Arabidopsis thaliana | AT1G49910 | cell cycle arrest protein BUB3 |
Babesia bovis | BBOV_II006880 | WD domain/ mitotic checkpoint protein |
Brugia malayi | Bm1_20110 | Mitotic checkpoint protein BUB3 |
Caenorhabditis elegans | CELE_Y54G9A.6 | Protein BUB-3 |
Dictyostelium discoideum | DDB_G0292134 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG7581 | CG7581 gene product from transcript CG7581-RB |
Echinococcus granulosus | EgrG_000256300 | mitotic checkpoint protein bub3 |
Echinococcus multilocularis | EmuJ_000256300 | mitotic checkpoint protein bub3 |
Giardia lamblia | GL50803_102890 | BUB3 |
Homo sapiens | ENSG00000154473 | BUB3 mitotic checkpoint protein |
Loa Loa (eye worm) | LOAG_01065 | mitotic checkpoint protein BUB3 |
Mus musculus | ENSMUSG00000066979 | budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_062730 | hypothetical protein |
Oryza sativa | 9267070 | Os07g0588500 |
Oryza sativa | 4333230 | Os03g0448600 |
Schistosoma japonicum | Sjp_0209220 | ko:K02180 cell cycle arrest protein BUB3, putative |
Schistosoma mansoni | Smp_045060 | mitotic checkpoint protein bub3 |
Schmidtea mediterranea | mk4.002330.01 | Putative mitotic checkpoint protein bub3 |
Toxoplasma gondii | TGME49_245470 | mitotic checkpoint protein, BUB3 family protein |
Theileria parva | TP02_0663 | hypothetical protein |
Trichomonas vaginalis | TVAG_545690 | mitotic checkpoint protein and poly(A)+ RNA export protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_245470 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.