Detailed view for LinJ.15.1180

Basic information

TDR Targets ID: 823970
Leishmania infantum, protein kinase, putative
Source Database / ID: 

pI: 6.7534 | Length (AA): 2698 | MW (Da): 287094 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain
PF00069   Protein kinase domain
PF00989   PAS fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0000160   two-component signal transduction system (phosphorelay)  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
266 598 4din (B) 34 374 20.00 0 0.83 0.122325 1.35
307 1567 4rz7 (A) 6 791 23.00 0 1 -0.0964168 2.22
341 461 5c8w (A) 151 269 22.00 0 1 0.441048 -1.08
1265 1648 3uto (A) 122 498 21.00 0 1 0.333528 0.37
1282 1660 5o2c (A) 129 490 24.00 0 1 0.343674 0.25
1294 1606 2b9h (A) 8 346 22.00 0 1 0.296212 -0.32
1297 1601 3c0g (B) 10 305 23.00 0 1 0.343247 -0.32
1299 1598 3ggf (A) 24 295 33.00 0 1 0.372393 0.07
1299 1576 3f3z (A) 28 292 28.00 0 1 0.419239 -0.38
1304 1562 4bf2 (B) 685 933 42.00 0 1 0.352897 0.15
1668 1792 3s6l (A) 34 156 33.00 0.67 0.33 0.228231 0.83

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_160588)

Species Accession Gene Product
Leishmania braziliensis LbrM.15.1140   protein kinase, putative
Leishmania donovani LdBPK_151180.1   protein kinase, putative
Leishmania infantum LinJ.15.1180   protein kinase, putative
Leishmania major LmjF.15.1200   protein kinase, putative
Leishmania mexicana LmxM.15.1200   protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 28.0% 175 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 26.3% 205 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.8% 291 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 26.3% 297 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 21.0% 271 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.0% 289 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LinJ.15.1180 (Leishmania infantum), protein kinase, putative
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