Detailed view for PBANKA_0938900

Basic information

TDR Targets ID: 824938
Plasmodium berghei, IWS1-like protein, putative
Source Database / ID: 

pI: 7.8446 | Length (AA): 514 | MW (Da): 59743 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08711   TFIIS helical bundle-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
137 231 1jbj (A) 24 125 31.00 0.39 0.03 0.122225 1.09
264 399 3nfq (A) 8 154 27.00 0.0000015 1 0.717991 -1.7
267 398 2xpp (A) 60 191 27.00 0.00000062 1 0.851209 -2.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Ookinete. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Gametocyte, 16 hs Trophozoite, 22 hs Schizont, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile 4 hs Ring, Erthyrocytic stages. Otto TD Yeoh LM
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_128599)

Species Accession Gene Product
Arabidopsis thaliana AT4G19000   INTERACTS WITH SPT6-like protein IWS2
Arabidopsis thaliana AT1G32130   IWS1-like protein
Babesia bovis BBOV_II003510   conserved hypothetical protein
Brugia malayi Bm1_13230   IWS1 C-terminus family protein
Candida albicans CaO19.13630   similar to S. cerevisiae YPR133C
Candida albicans CaO19.6252   similar to S. cerevisiae YPR133C
Caenorhabditis elegans CELE_F13B12.1   Protein F13B12.1
Cryptosporidium hominis Chro.50270   hypothetical protein
Cryptosporidium parvum cgd5_1150   iwsip-like protein
Dictyostelium discoideum DDB_G0274327   IWS1 family protein
Drosophila melanogaster Dmel_CG9915   CG9915 gene product from transcript CG9915-RC
Echinococcus granulosus EgrG_000246900   protein iws1
Echinococcus multilocularis EmuJ_000246900   protein iws1
Homo sapiens ENSG00000163166   IWS1 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_11637   IWS1 family protein
Mus musculus ENSMUSG00000024384   IWS1 homolog (S. cerevisiae)
Neospora caninum NCLIV_045710   hypothetical protein
Oryza sativa 4325206   Os01g0147200
Plasmodium berghei PBANKA_0938900   IWS1-like protein, putative
Plasmodium falciparum PF3D7_1108000   IWS1-like protein, putative
Plasmodium knowlesi PKNH_0905600   IWS1-like protein, putative
Plasmodium vivax PVX_091080   hypothetical protein, conserved
Plasmodium yoelii PY03357   unnamed protein product, putative
Saccharomyces cerevisiae YPR133C   Spn1p
Schistosoma japonicum Sjp_0215200   IWS1 homolog, putative
Schistosoma mansoni Smp_008500.1   Transcription factor IWS1
Schistosoma mansoni Smp_008500.2   Transcription factor IWS1
Schmidtea mediterranea mk4.004659.02   Protein IWS1 homolog
Schmidtea mediterranea mk4.000188.13   Protein IWS1 homolog
Schmidtea mediterranea mk4.001435.02   Protein IWS1 homolog
Schmidtea mediterranea mk4.003340.00   Protein IWS1 homolog
Schmidtea mediterranea mk4.001214.02   Protein IWS1 homolog
Schmidtea mediterranea mk4.004572.00   Protein IWS1 homolog
Toxoplasma gondii TGME49_227560   IWS1 transcription factor, putative
Theileria parva TP04_0233   hypothetical protein
Trichomonas vaginalis TVAG_267140   transcription factor IWS1, putative

Essentiality

PBANKA_0938900 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
CELE_F13B12.1 Caenorhabditis elegans sterile wormbase
YPR133C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0938900 this record Plasmodium berghei Slow plasmo
TGME49_227560 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_0938900 (Plasmodium berghei), IWS1-like protein, putative
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