Detailed view for PBANKA_1453700

Basic information

TDR Targets ID: 825867
Plasmodium berghei, AP2 domain transcription factor, putative
Source Database / ID: 

pI: 5.6057 | Length (AA): 1485 | MW (Da): 171650 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00847   AP2 domain
PF14733   AP2-coincident C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0003700   transcription factor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 277 4mu6 (A) 6 298 12.00 0.2 0 0.240045 -0.21
19 846 1wxr (A) 148 999 12.00 0 0.02 0.238376 1.66
56 278 4tql (A) 14 235 10.00 0.1 0 0.301068 -0.93
181 1070 5xus (A) 26 965 17.00 0 0.95 0.375127 1.3
538 802 4o87 (A) 13 319 28.00 0.069 0.14 0.214451 0.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile 4 hs Ring, Female gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Gametocyte, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Ookinete. Otto TD
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_153590)

Species Accession Gene Product
Babesia bovis BBOV_IV011830   hypothetical protein
Plasmodium berghei PBANKA_1453700   AP2 domain transcription factor, putative
Plasmodium falciparum PF3D7_1239200   AP2 domain transcription factor, putative
Plasmodium knowlesi PKNH_1459000   AP2 domain transcription factor, putative
Plasmodium vivax PVX_100910   transcription factor with AP2 domain(s), putative
Plasmodium yoelii PY06790   ERYTHROCYTE MEMBRANE PROTEIN PFEMP3
Theileria parva TP01_1126   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Escherichia coli Dihydrofolate reductase type 1 157 aa 23.6% 140 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_1453700 (Plasmodium berghei), AP2 domain transcription factor, putative
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