pI: 7.8623 |
Length (AA): 458 |
MW (Da): 52116 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Gametocyte, Ookinete, 4 hs Ring, 22 hs Schizont, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Erthyrocytic stages. | Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | 16 hs Trophozoite. | Otto TD |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_141740)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_II003200 | conserved hypothetical protein |
Cryptosporidium hominis | Chro.70069 | hypothetical protein |
Cryptosporidium parvum | cgd7_550 | hypothetical protein wtih 9 transmembrane domains, possible apicomplexan-specific protein |
Neospora caninum | NCLIV_065970 | hypothetical protein, conserved |
Plasmodium berghei | PBANKA_1115300 | glideosome-associated protein 40, putative |
Plasmodium falciparum | PF3D7_0515700 | glideosome-associated protein 40, putative |
Plasmodium knowlesi | PKNH_1017500 | glideosome-associated protein 40, putative |
Plasmodium vivax | PVX_080460 | glideosome-associated protein 40, putative |
Plasmodium yoelii | PY00232 | hypothetical protein |
Toxoplasma gondii | TGME49_249850 | GAP40 protein |
Theileria parva | TP04_0273 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1115300 this record | Plasmodium berghei | Essential | plasmo |
TGME49_249850 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.