Detailed view for PBANKA_0612000

Basic information

TDR Targets ID: 826258
Plasmodium berghei, ATP-dependent Clp protease proteolytic subunit, putative
Source Database / ID: 

pI: 9.5159 | Length (AA): 240 | MW (Da): 27959 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00574   Clp protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
57 239 4gm2 (A) 61 243 91.00 0 1 1.9171 -1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile 16 hs Trophozoite. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Erthyrocytic stages. Yeoh LM
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Gametocyte, Ookinete, 4 hs Ring, 22 hs Schizont, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_134854)

Species Accession Gene Product
Arabidopsis thaliana AT4G17040   ATP-dependent Clp protease proteolytic subunit-related protein 4
Cryptosporidium hominis Chro.40329   hypothetical protein
Oryza sativa 4325168   Os01g0271400
Plasmodium berghei PBANKA_0612000   ATP-dependent Clp protease proteolytic subunit, putative
Plasmodium berghei PBANKA_0612100   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1436700   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1436800   ATP-dependent Clp protease proteolytic subunit
Plasmodium knowlesi PKNH_0423300   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0423400   ATP-dependent Clp protease proteolytic subunit, putative
Plasmodium vivax PVX_084698   ATP-dependent Clp protease proteolytic subunit, putative
Plasmodium vivax PVX_084702   ATP-dependent Clp protease proteolytic subunit, putative
Plasmodium yoelii PY00557   Clp protease
Plasmodium yoelii PY00556   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain NCTC 8325) ATP-dependent Clp protease proteolytic subunit 195 aa 35.6% 180 aa Compounds References
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit 197 aa 36.7% 180 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_0612000 (Plasmodium berghei), ATP-dependent Clp protease proteolytic subunit, putative
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