pI: 10.7874 |
Length (AA): 188 |
MW (Da): 22789 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 187 | 5sx8 (B) | 373 | 547 | 30.00 | 0.52 | 0.41 | 1.06567 | 0.49 |
65 | 175 | 4uos (A) | 7 | 118 | 32.00 | 0.022 | 0.98 | 1.05533 | -1.36 |
69 | 137 | 1mjh (A) | 43 | 153 | 42.00 | 0.62 | 0.46 | 0.507921 | -0.74 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Gametocyte, Ookinete, 4 hs Ring, 22 hs Schizont, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | 16 hs Trophozoite, Erthyrocytic stages. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Male gametocyte. | Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_129107)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G12650 | hypothetical protein |
Babesia bovis | BBOV_III009460 | conserved hypothetical protein |
Brugia malayi | Bm1_19725 | C6orf153 protein |
Candida albicans | CaO19.9898 | similar to S. cerevisiae YOR287, possible coil-coil protein involved in pre-rRNA processing |
Candida albicans | CaO19.2362 | similar to S. cerevisiae YOR287, possible coil-coil protein involved in pre-rRNA processing |
Cryptosporidium hominis | Chro.30026 | hypothetical protein |
Cryptosporidium parvum | cgd3_170 | hypothetical protein |
Dictyostelium discoideum | DDB_G0278751 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8461 | CG8461 gene product from transcript CG8461-RA |
Echinococcus granulosus | EgrG_001079000 | rRNA biogenesis protein RRP36 |
Entamoeba histolytica | EHI_007980 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_001079000 | rRNA biogenesis protein RRP36 |
Giardia lamblia | GL50803_33809 | Hypothetical protein |
Homo sapiens | ENSG00000124541 | ribosomal RNA processing 36 homolog (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_06184 | hypothetical protein |
Mus musculus | ENSMUSG00000023971 | ribosomal RNA processing 36 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_018980 | hypothetical protein, conserved |
Oryza sativa | 4347627 | Os09g0525200 |
Onchocerca volvulus | OVOC6028 |
|
Plasmodium berghei | PBANKA_0203900 | rRNA biogenesis protein RRP36, putative |
Plasmodium falciparum | PF3D7_0109700 | rRNA biogenesis protein RRP36, putative |
Plasmodium knowlesi | PKNH_0204100 | rRNA biogenesis protein RRP36, putative |
Plasmodium vivax | PVX_081305 | hypothetical protein, conserved |
Saccharomyces cerevisiae | YOR287C | Rrp36p |
Schistosoma japonicum | Sjp_0029870 | expressed protein |
Schistosoma mansoni | Smp_026300 | hypothetical protein |
Schmidtea mediterranea | mk4.001361.01 | |
Toxoplasma gondii | TGME49_244420 | hypothetical protein |
Theileria parva | TP04_0856 | hypothetical protein |
Trichomonas vaginalis | TVAG_315300 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_330960 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YOR287C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0203900 this record | Plasmodium berghei | Slow | plasmo |
TGME49_244420 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.