Detailed view for PBANKA_1205200

Basic information

TDR Targets ID: 826987
Plasmodium berghei, conserved membrane protein, unknown function
Source Database / ID: 

pI: 10.0015 | Length (AA): 271 | MW (Da): 31438 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09767   Predicted membrane protein (DUF2053)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 114 3odj (A) 57 184 30.00 0.88 0.03 0.261874 2.14
127 250 5nw5 (A) 259 395 17.00 0 0.68 0.488665 0.3
192 263 4d10 (C) 219 297 26.00 0.64 0.03 0.455883 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Gametocyte, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Ookinete, Erthyrocytic stages. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female gametocyte. Yeoh LM
Show/Hide expression data references
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.

Orthologs

Ortholog group members (OG5_131748)

Species Accession Gene Product
Arabidopsis thaliana AT1G47640   hypothetical protein
Babesia bovis BBOV_I002280   membrane protein, putative
Brugia malayi Bm1_05455   seven transmembrane domain protein
Caenorhabditis elegans CELE_ZK418.5   Protein ZK418.5
Dictyostelium discoideum DDB_G0293704   seven transmembrane domain protein
Drosophila melanogaster Dmel_CG5861   CG5861 gene product from transcript CG5861-RA
Homo sapiens ENSG00000105677   transmembrane protein 147
Loa Loa (eye worm) LOAG_08333   hypothetical protein
Loa Loa (eye worm) LOAG_10170   hypothetical protein
Mus musculus ENSMUSG00000006315   transmembrane protein 147
Neospora caninum NCLIV_046670   AGAP008757-PA, related
Oryza sativa 4334226   Os03g0766000
Onchocerca volvulus OVOC9083   Transmembrane protein 147 homolog
Plasmodium berghei PBANKA_1205200   conserved membrane protein, unknown function
Plasmodium falciparum PF3D7_1007000   conserved membrane protein, unknown function
Plasmodium knowlesi PKNH_0805800   conserved membrane protein, unknown function
Plasmodium vivax PVX_094545   conserved membrane protein, unknown function
Plasmodium yoelii PY01878   hypothetical protein
Schistosoma japonicum Sjp_0216640   Transmembrane protein 147, putative
Schistosoma mansoni Smp_071560   small seven transmembrane domain-containing protein
Schmidtea mediterranea mk4.000585.02  
Toxoplasma gondii TGME49_226270   hypothetical protein

Essentiality

PBANKA_1205200 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1205200 this record Plasmodium berghei Dispensable plasmo
TGME49_226270 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_1205200 (Plasmodium berghei), conserved membrane protein, unknown function
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