Detailed view for PBANKA_1237800

Basic information

TDR Targets ID: 827199
Plasmodium berghei, multidrug resistance protein 1, putative
Source Database / ID: 

pI: 9.1258 | Length (AA): 1419 | MW (Da): 160938 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF00664   ABC transporter transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0042626   ATPase activity, coupled to transmembrane movement of substances  
GO:0016021   integral to membrane  
GO:0005524   ATP binding  
GO:0016887   ATPase activity  
GO:0055085   transmembrane transport  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 1407 4f4c (A) 19 1306 30.00 0 1 1.16924 0.26
38 695 2hyd (A) 1 578 29.00 0 1 0.620407 0.57
374 450 5eum (A) 346 421 36.00 0 0.98 0.533864 -0.89
375 689 2ghi (D) 18 250 50.00 0 1 0.312187 0.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Gametocyte, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Female gametocyte. Yeoh LM
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Ookinete. Otto TD
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_126596)

Species Accession Gene Product
Arabidopsis thaliana AT3G28860   ABC transporter B family member 19
Arabidopsis thaliana AT1G02530   P-glycoprotein 12
Arabidopsis thaliana AT1G27940   ABC transporter B family member 13
Arabidopsis thaliana AT4G25960   P-glycoprotein 2
Arabidopsis thaliana AT3G28345   ABC transporter B family member 15
Arabidopsis thaliana AT2G36910   ABC transporter B family member 1
Arabidopsis thaliana AT1G28010   ABC transporter B family member 14
Arabidopsis thaliana AT1G02520   P-glycoprotein 11
Arabidopsis thaliana AT2G39480   ABC transporter B family member 6
Arabidopsis thaliana AT3G55320   ABC transporter B family member 20
Arabidopsis thaliana AT3G62150   ABC transporter B family member 21
Arabidopsis thaliana AT4G01830   ABC transporter B family member 5
Arabidopsis thaliana AT3G28390   ABC transporter B family member 18
Arabidopsis thaliana AT3G28360   ABC transporter B family member 16
Arabidopsis thaliana AT1G10680   ABC transporter B family member 10
Arabidopsis thaliana AT5G46540   ABC transporter B family member 7
Arabidopsis thaliana AT2G47000   auxin efflux transmembrane transporter MDR4
Arabidopsis thaliana AT3G28380   ABC transporter B family member 17
Arabidopsis thaliana AT4G18050   P-glycoprotein 9
Arabidopsis thaliana AT4G01820   ABC transporter B family member 3
Arabidopsis thaliana AT3G28415   ABC transporter B family member 22
Brugia malayi Bm1_43165   ABC transporter family protein
Brugia malayi Bm1_24870   multidrug resistance protein 3
Candida albicans CaO19.7440   potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export
Caenorhabditis elegans CELE_K08E7.9   Protein PGP-1
Caenorhabditis elegans CELE_T21E8.3   Protein PGP-8
Caenorhabditis elegans CELE_DH11.3   Protein PGP-11
Caenorhabditis elegans CELE_T21E8.1   Protein PGP-6, isoform B
Caenorhabditis elegans CELE_F22E10.2   Protein PGP-13
Caenorhabditis elegans CELE_F42E11.1   Protein PGP-4, isoform B
Caenorhabditis elegans CELE_C34G6.4   Protein PGP-2
Caenorhabditis elegans CELE_C05A9.1   Protein PGP-5, isoform B
Caenorhabditis elegans CELE_T21E8.2   Protein PGP-7
Caenorhabditis elegans CELE_F22E10.3   Protein PGP-14
Caenorhabditis elegans CELE_C47A10.1   Protein PGP-9
Caenorhabditis elegans CELE_ZK455.7   Protein PGP-3
Caenorhabditis elegans CELE_F22E10.1   Protein PGP-12
Cryptosporidium hominis Chro.60540   ATP-binding cassette protein 3
Cryptosporidium parvum cgd6_4700   ATP-binding cassette transporter
Chlamydia trachomatis CT_264   ABC transporter ATP binding protein/permease
Dictyostelium discoideum DDB_G0291714   ABC transporter B family protein
Dictyostelium discoideum DDB_G0293438   ABC transporter B family protein
Drosophila melanogaster Dmel_CG10181   Multiple drug resistance 65
Drosophila melanogaster Dmel_CG8523   Multi drug resistance 50
Drosophila melanogaster Dmel_CG10226   CG10226 gene product from transcript CG10226-RA
Drosophila melanogaster Dmel_CG3879   Multi drug resistance 49
Escherichia coli b0914   fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component
Escherichia coli b0449   putative multidrug transporter subunit of ABC superfamily, ATP-binding component
Echinococcus granulosus EgrG_000901300   ATP binding cassette subfamily B MDR:TAP
Echinococcus granulosus EgrG_002002700   multidrug resistance protein 1
Echinococcus granulosus EgrG_000160100   multidrug resistance protein 1
Echinococcus granulosus EgrG_000159900   multidrug resistance protein 1
Echinococcus granulosus EgrG_000931700   ATP binding cassette subfamily B MDR:TAP
Echinococcus granulosus EgrG_000160300   multidrug resistance protein 1
Echinococcus granulosus EgrG_000161100   5'partial|ATP binding cassette sub family B
Echinococcus granulosus EgrG_000901000   ATP binding cassette subfamily B MDR:TAP
Echinococcus granulosus EgrG_000777700   ATP binding cassette subfamily B MDR:TAP
Echinococcus granulosus EgrG_000900900   multidrug resistance protein 1
Entamoeba histolytica EHI_186350   P-glycoprotein-2
Entamoeba histolytica EHI_125030   P-glycoprotein 5, putative
Entamoeba histolytica EHI_175450   P-glycoprotein-5
Entamoeba histolytica EHI_114150   P-glycoprotein-1
Entamoeba histolytica EHI_186600   P-glycoprotein-2, putative
Entamoeba histolytica EHI_101230   P-glyco protein 6, putative
Entamoeba histolytica EHI_016380   P-glycoprotein-2
Echinococcus multilocularis EmuJ_000931700   ATP binding cassette subfamily B (MDR:TAP)
Echinococcus multilocularis EmuJ_000161100   ATP binding cassette sub family B
Echinococcus multilocularis EmuJ_000159900   multidrug resistance protein 1
Echinococcus multilocularis EmuJ_000777700   ATP binding cassette subfamily B (MDR:TAP)
Echinococcus multilocularis EmuJ_000900900   multidrug resistance protein 1
Echinococcus multilocularis EmuJ_000160100   multidrug resistance protein 1
Echinococcus multilocularis EmuJ_000160300   ATP binding cassette subfamily B (MDR:TAP)
Echinococcus multilocularis EmuJ_000901300   ATP binding cassette subfamily B (MDR:TAP)
Echinococcus multilocularis EmuJ_000901000   ATP binding cassette subfamily B (MDR:TAP)
Homo sapiens ENSG00000004846   ATP-binding cassette, sub-family B (MDR/TAP), member 5
Homo sapiens ENSG00000005471   ATP-binding cassette, sub-family B (MDR/TAP), member 4
Homo sapiens ENSG00000073734   ATP-binding cassette, sub-family B (MDR/TAP), member 11
Homo sapiens ENSG00000085563   ATP-binding cassette, sub-family B (MDR/TAP), member 1
Leishmania braziliensis LbrM.26.2600   p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein
Leishmania donovani LdBPK_341060.1   p-glycoprotein
Leishmania donovani LdBPK_262700.1   ATP-binding cassette protein subfamily B, member 2, putative
Leishmania infantum LinJ.26.2700   ATP-binding cassette protein subfamily B, member 2, putative
Leishmania infantum LinJ.34.1060   p-glycoprotein
Leishmania major LmjF.26.2670   ATP-binding cassette protein subfamily B, member 2, putative
Leishmania major LmjF.34.0990   p-glycoprotein
Leishmania mexicana LmxM.26.2670   p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein
Leishmania mexicana LmxM.33.0990   p-glycoprotein
Loa Loa (eye worm) LOAG_07988   hypothetical protein
Loa Loa (eye worm) LOAG_06601   multidrug resistance protein 3
Loa Loa (eye worm) LOAG_03722   hypothetical protein
Loa Loa (eye worm) LOAG_05152   ATP-binding cassette sub-family B member 2
Loa Loa (eye worm) LOAG_11527   hypothetical protein
Mus musculus ENSMUSG00000040584   ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Mus musculus ENSMUSG00000072791   ATP-binding cassette, sub-family B (MDR/TAP), member 5
Mus musculus ENSMUSG00000027048   ATP-binding cassette, sub-family B (MDR/TAP), member 11
Mus musculus ENSMUSG00000028970   ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Mus musculus ENSMUSG00000042476   ATP-binding cassette, sub-family B (MDR/TAP), member 4
Mycobacterium tuberculosis Rv0194   Probable transmembrane multidrug efflux pump
Neospora caninum NCLIV_026720   ATP-binding cassette, sub-family B (MDR/TAP), member 4, related
Neospora caninum NCLIV_015830   hypothetical protein
Oryza sativa 4339511   Os05g0548300
Oryza sativa 4337173   Os04g0642000
Oryza sativa 4328568   Os02g0190000
Oryza sativa 4332438   Os03g0280000
Oryza sativa 4324720   Os01g0723800
Oryza sativa 4330390   Os02g0693700
Oryza sativa 4324305   Os01g0976100
Oryza sativa 9270100   Os02g0323000
Oryza sativa 9268765   Os01g0534700
Oryza sativa 4328566   Os02g0189800
Oryza sativa 4336042   Os04g0459000
Oryza sativa 4346344   Os08g0564300
Oryza sativa 4328570   Os02g0190300
Oryza sativa 9270932   Os05g0137100
Oryza sativa 9269254   Os02g0190101
Oryza sativa 4326410   Os01g0533900
Oryza sativa 4336189   Os04g0481700
Onchocerca volvulus OVOC10280  
Plasmodium berghei PBANKA_1237800   multidrug resistance protein 1, putative
Plasmodium falciparum PF3D7_0523000   multidrug resistance protein 1
Plasmodium knowlesi PKNH_1009900   multidrug resistance protein 1, putative
Plasmodium vivax PVX_080100   multidrug resistance protein 1, putative
Plasmodium yoelii PY00245   multidrug resistance protein
Saccharomyces cerevisiae YKL209C   ATP-binding cassette alpha-factor transporter STE6
Schistosoma japonicum Sjp_0093230   Multidrug resistance protein 1, putative
Schistosoma japonicum Sjp_0122070   Multidrug resistance protein 3, putative
Schistosoma japonicum Sjp_0072980   Multidrug resistance protein 1, putative
Schistosoma japonicum Sjp_0107590   Multidrug resistance protein 1, putative
Schistosoma japonicum Sjp_0031160   Bile salt export pump, putative
Schistosoma japonicum Sjp_0066120   ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative
Schistosoma japonicum Sjp_0122750   Multidrug resistance protein 2, putative
Schistosoma japonicum Sjp_0012730   Multidrug resistance protein 1, putative
Schistosoma japonicum Sjp_0039970   ATP-binding cassette sub-family B member 5, putative
Schistosoma japonicum Sjp_0093240   Multidrug resistance protein 3, putative
Schistosoma mansoni Smp_137080   multidrug resistance protein
Schistosoma mansoni Smp_170820   multidrug resistance protein
Schistosoma mansoni Smp_089200   multidrug resistance protein
Schistosoma mansoni Smp_055780   smdr2
Schmidtea mediterranea mk4.011204.00  
Schmidtea mediterranea mk4.020366.01   Multidrug resistance protein 1, 2, 3
Schmidtea mediterranea mk4.020420.00  
Schmidtea mediterranea mk4.000357.04  
Schmidtea mediterranea mk4.005899.00  
Schmidtea mediterranea mk4.012079.01  
Schmidtea mediterranea mk4.020228.00   Multidrug resistance protein 1, 2, 3
Schmidtea mediterranea mk4.026452.00  
Schmidtea mediterranea mk4.012079.00  
Schmidtea mediterranea mk4.013711.03  
Schmidtea mediterranea mk4.046452.00  
Schmidtea mediterranea mk4.005899.01  
Schmidtea mediterranea mk4.000357.05  
Schmidtea mediterranea mk4.010001.00  
Schmidtea mediterranea mk4.000357.01   Multidrug resistance protein 1, 2, 3
Toxoplasma gondii TGME49_239020   ABC transporter transmembrane region domain-containing protein
Toxoplasma gondii TGME49_260310   ATP-binding cassette transporter ABC.B1
Trichomonas vaginalis TVAG_190320   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_147100   ABC transporter, putative
Trichomonas vaginalis TVAG_049020   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_127410   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_223680   ABC transporter, half transporter, putative
Trichomonas vaginalis TVAG_188980   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_070890   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_352350   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_190330   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_078520   abcb9, putative
Trichomonas vaginalis TVAG_139960   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_487000   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_162060   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_145830   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_088690   abcb9, putative
Trichomonas vaginalis TVAG_494720   ABC transporter, putative
Trichomonas vaginalis TVAG_352380   taga, putative
Trichomonas vaginalis TVAG_381050   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_280000   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_241640   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_124750   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_109910   ABC transporter, putative
Trichomonas vaginalis TVAG_352360   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_373020   ABC transporter, half transporter, putative
Trichomonas vaginalis TVAG_352390   ATP-binding cassette transporter, putative
Trichomonas vaginalis TVAG_542450   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_172140   abcb9, putative
Trichomonas vaginalis TVAG_209070   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_494730   lipid A export ATP-binding/permease protein msba, putative
Trichomonas vaginalis TVAG_542460   multidrug resistance protein 1, 2, putative
Trichomonas vaginalis TVAG_219580   ABC transporter, putative

Essentiality

PBANKA_1237800 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu196 Mycobacterium tuberculosis non-essential nmpdr
b0449 Escherichia coli non-essential goodall
b0914 Escherichia coli essential goodall
CELE_C47A10.1 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1237800 this record Plasmodium berghei Essential plasmo
TGME49_260310 Toxoplasma gondii Essentiality uncertain sidik
TGME49_239020 Toxoplasma gondii Essentiality uncertain sidik
TGME49_260310 Toxoplasma gondii Probably non-essential sidik
TGME49_239020 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Bile salt export pump Compounds References
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1A Compounds References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Compounds References
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B Compounds References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PBANKA_1237800 (Plasmodium berghei), multidrug resistance protein 1, putative
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