Detailed view for PBANKA_0712300

Basic information

TDR Targets ID: 827300
Plasmodium berghei, zinc finger protein, putative
Source Database / ID: 

pI: 8.5932 | Length (AA): 226 | MW (Da): 26187 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01428   AN1-like Zinc finger
PF01754   A20-like zinc finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 61 2kzy (A) 3 62 35.00 0.0000000044 0.99 0.662712 0.23
13 46 2c7n (E) 17 50 44.00 0.000013 0.97 0.738243 -0.74
35 147 3zur (A) 789 907 13.00 0 0.01 0.6658 -1.42
142 207 1wfl (A) 3 68 38.00 0.000000000019 0.99 0.658835 0.89

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Gametocyte, Ookinete, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Male gametocyte. Yeoh LM
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_127624)

Species Accession Gene Product
Arabidopsis thaliana AT3G52800   zinc finger A20 and AN1 domain-containing stress-associated protein 6
Arabidopsis thaliana AT2G27580   zinc finger A20 and AN1 domain-containing stress-associated protein 3
Arabidopsis thaliana AT1G12440   A20/AN1-like zinc finger family protein
Arabidopsis thaliana AT1G51200   zinc finger A20 and AN1 domain-containing stress-associated protein 2
Arabidopsis thaliana AT4G22820   A20/AN1-like zinc finger family protein
Arabidopsis thaliana AT4G12040   zinc finger A20 and AN1 domain-containing stress-associated protein 7
Arabidopsis thaliana AT2G36320   zinc finger A20 and AN1 domain-containing stress-associated protein 4
Babesia bovis BBOV_III002670   conserved hypothetical protein
Brugia malayi Bm1_56660   AN1-like Zinc finger family protein
Caenorhabditis elegans CELE_F22D6.2   Protein F22D6.2
Cryptosporidium hominis Chro.10110   zinc finger transcription factor ZFP33
Cryptosporidium parvum cgd1_910   ZnF A20 and Znf AN1 domains, involved in signaling
Dictyostelium discoideum DDB_G0276881   hypothetical protein
Drosophila melanogaster Dmel_CG45050   CG45050 gene product from transcript CG45050-RF
Drosophila melanogaster Dmel_CG43675   CG43675 gene product from transcript CG43675-RC
Echinococcus granulosus EgrG_001022700   AN1 type zinc finger protein 5
Echinococcus granulosus EgrG_000960100   zinc finger A20 and AN1 domain containing protein
Echinococcus granulosus EgrG_000337500   Zinc finger A20 type
Echinococcus multilocularis EmuJ_001022700   AN1 type zinc finger protein 5
Echinococcus multilocularis EmuJ_000337500   Zinc finger, A20 type
Echinococcus multilocularis EmuJ_000960100   zinc finger A20 and AN1 domain containing protein
Homo sapiens ENSG00000107372   zinc finger, AN1-type domain 5
Homo sapiens ENSG00000086666   zinc finger, AN1-type domain 6
Loa Loa (eye worm) LOAG_10887   hypothetical protein
Mus musculus ENSMUSG00000030629   zinc finger, AN1-type domain 6
Mus musculus 22682   zinc finger, AN1-type domain 5
Neospora caninum NCLIV_005310   LOC397781 protein, related
Oryza sativa 4325591   Os01g0718000
Oryza sativa 4334393   Os03g0793000
Oryza sativa 4329544   Os02g0530300
Oryza sativa 4342503   Os07g0168800
Oryza sativa 4334395   Os03g0793300
Oryza sativa 4341520   Os06g0612800
Oryza sativa 4334392   Os03g0792900
Oryza sativa 4328609   Os02g0195600
Onchocerca volvulus OVOC1737   Zinc finger protein, putative homolog
Plasmodium berghei PBANKA_0712300   zinc finger protein, putative
Plasmodium falciparum PF3D7_0818500   zinc finger protein, putative
Plasmodium knowlesi PKNH_0501400   zinc finger protein, putative
Plasmodium vivax PVX_089490   hypothetical protein, conserved
Plasmodium yoelii PY00088   hypothetical protein
Schistosoma japonicum Sjp_0124720   Zinc finger A20 and AN1 domain-containing stress-associated protein 6, putative
Schistosoma japonicum Sjp_0039700   AN1-type zinc finger protein 6, putative
Schistosoma japonicum Sjp_0208610   Zinc finger A20 and AN1 domain-containing stress-associated protein 4, putative
Schistosoma mansoni Smp_105210   zinc finger protein
Schistosoma mansoni Smp_072720   zinc finger protein
Schmidtea mediterranea mk4.001843.00   Putative zinc finger protein
Schmidtea mediterranea mk4.001971.03   Putative zinc finger protein
Schmidtea mediterranea mk4.023205.00   Putative zinc finger protein
Schmidtea mediterranea mk4.004949.00   Putative zinc finger protein
Schmidtea mediterranea mk4.000033.33   Putative zinc finger protein
Schmidtea mediterranea mk4.024409.00   Putative zinc finger protein
Schmidtea mediterranea mk4.021225.00  
Schmidtea mediterranea mk4.021695.01  
Schmidtea mediterranea mk4.006757.00  
Schmidtea mediterranea mk4.002144.05  
Schmidtea mediterranea mk4.004949.01   Putative zinc finger protein
Schmidtea mediterranea mk4.012051.01   Putative zinc finger protein
Schmidtea mediterranea mk4.007565.00   Putative zinc finger protein
Schmidtea mediterranea mk4.001971.04   Putative zinc finger protein
Schmidtea mediterranea mk4.003993.00  
Toxoplasma gondii TGME49_221910   AN1 family Zinc finger domain-containing protein
Theileria parva TP04_0113   zinc finger protein, putative

Essentiality

PBANKA_0712300 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0712300 this record Plasmodium berghei Slow plasmo
TGME49_221910 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PBANKA_0712300 (Plasmodium berghei), zinc finger protein, putative
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