pI: 6.5045 |
Length (AA): 274 |
MW (Da): 31953 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
70 | 187 | 3ulp (A) | 77 | 194 | 93.00 | 0 | 1 | 1.53226 | -1.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Erthyrocytic stages. | Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | 16 hs Trophozoite, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Gametocyte, Ookinete, 4 hs Ring, 22 hs Schizont, Female gametocyte. | Otto TD Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_127389)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G18580 | single-strand DNA-binding protein |
Arabidopsis thaliana | AT4G11060 | mitochondrially targeted single-stranded DNA binding protein |
Candida albicans | CaO19.2483 | single-stranded zinc finger DNA-binding protein |
Candida albicans | CaO19.10019 | single-stranded zinc finger DNA-binding protein |
Caenorhabditis elegans | CELE_PAR2.1 | Protein MTSS-1 |
Chlamydia trachomatis | CT_044 | single-stranded DNA-binding protein |
Dictyostelium discoideum | DDB_G0292230 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4337 | mitochondrial single stranded DNA-binding protein |
Escherichia coli | b4059 | single-stranded DNA-binding protein |
Echinococcus granulosus | EgrG_001119700 | single strand binding protein |
Echinococcus multilocularis | EmuJ_001119700 | single strand binding protein |
Homo sapiens | ENSG00000106028 | single-stranded DNA binding protein 1, mitochondrial |
Mycobacterium leprae | ML2684c | PROBABLE SINGLE-STRAND BINDING PROTEIN SSB (HELIX-DESTABILIZING PROTEIN) |
Mus musculus | ENSMUSG00000029911 | single-stranded DNA binding protein 1 |
Mycobacterium tuberculosis | Rv0054 | Single-strand binding protein Ssb (helix-destabilizing protein) |
Mycobacterium ulcerans | MUL_0072 | single-stranded DNA-binding protein |
Neospora caninum | NCLIV_006840 | hypothetical protein |
Oryza sativa | 4335578 | Os04g0363700 |
Oryza sativa | 4339275 | Os05g0509700 |
Oryza sativa | 4326564 | Os01g0642900 |
Plasmodium berghei | PBANKA_1108400 | single-stranded DNA-binding protein, putative |
Plasmodium falciparum | PF3D7_0508800 | single-stranded DNA-binding protein |
Plasmodium knowlesi | PKNH_1024800 | single-stranded DNA-binding protein, putative |
Plasmodium vivax | PVX_098000 | single-strand binding protein, putative |
Plasmodium yoelii | PY05238 | SINGLE-STRAND BINDING PROTEIN |
Saccharomyces cerevisiae | YCR028C-A | Rim1p |
Toxoplasma gondii | TGME49_297940 | single-strand binding protein |
Treponema pallidum | TP0062 | single-strand DNA binding protein (ssb) |
Wolbachia endosymbiont of Brugia malayi | Wbm0211 | single-stranded DNA-binding protein, ssb |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b4059 | Escherichia coli | essential | goodall |
PBANKA_1108400 this record | Plasmodium berghei | Slow | plasmo |
TGME49_297940 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.