pI: 6.4 |
Length (AA): 516 |
MW (Da): 58895 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 375 | 5gip (A) | 4 | 376 | 20.00 | 0 | 1 | 0.900906 | 0.24 |
22 | 376 | 5gip (A) | 17 | 377 | 21.00 | 0 | 1 | 0.896885 | 0.48 |
34 | 215 | 4uos (A) | 2 | 177 | 14.00 | 0.058 | 0.12 | 0.557613 | -1.06 |
131 | 375 | 2ozb (B) | 87 | 333 | 35.00 | 0 | 1 | 0.847906 | -0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Ookinete. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Gametocyte, 22 hs Schizont, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_128306)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G60170 | protein EMBRYO DEFECTIVE 1220 |
Babesia bovis | BBOV_II006320 | pre-mRNA processing ribonucleoprotein binding region-containing protein |
Brugia malayi | Bm1_29095 | SnoRNA binding domain containing protein |
Candida albicans | CaO19.82 | similar to N terminus of S. cerevisiae U4/U6 snRNP 61kd protein PRP31 (YGR091W) |
Candida albicans | CaO19.1296 | similar to C terminus of S. cerevisiae U4/U6 snRNP 61kd protein PRP31 (YGR091W) |
Candida albicans | CaO19.8876 | similar to C terminus of U4/U6 snRNP 61kd protein |
Caenorhabditis elegans | CELE_Y110A7A.8 | Protein PRP-31 |
Cryptosporidium hominis | Chro.40029 | snoRNA binding domain |
Cryptosporidium parvum | cgd4_150 | pre-mRNA splicing protein; Prp31p--like |
Dictyostelium discoideum | DDB_G0289595 | pre-mRNA processing factor 31 |
Drosophila melanogaster | Dmel_CG6876 | CG6876 gene product from transcript CG6876-RA |
Echinococcus granulosus | EgrG_001076000 | U4:U6 small nuclear ribonucleoprotein Prp31 |
Entamoeba histolytica | EHI_147490 | pre-mRNA splicing factor, putative |
Echinococcus multilocularis | EmuJ_001076000 | U4:U6 small nuclear ribonucleoprotein Prp31 |
Homo sapiens | ENSG00000105618 | pre-mRNA processing factor 31 |
Leishmania braziliensis | LbrM.33.0140 | trans-splicing factor, putative |
Leishmania donovani | LdBPK_330140.1 | trans-splicing factor, putative |
Leishmania infantum | LinJ.33.0140 | trans-splicing factor, putative |
Leishmania major | LmjF.33.0130 | trans-splicing factor, putative |
Leishmania mexicana | LmxM.32.0130 | trans-splicing factor, putative |
Loa Loa (eye worm) | LOAG_08730 | serologically defined breast cancer antigen NY-BR-99 |
Mus musculus | ENSMUSG00000008373 | PRP31 pre-mRNA processing factor 31 homolog (yeast) |
Neospora caninum | NCLIV_018700 | SnoRNA binding domain, related |
Oryza sativa | 4336619 | Os04g0555400 |
Oryza sativa | 4342372 | Os07g0141600 |
Plasmodium berghei | PBANKA_1006700 | U4/U6 small nuclear ribonucleoprotein PRP31, putative |
Plasmodium falciparum | PF3D7_0409100 | U4/U6 small nuclear ribonucleoprotein PRP31, putative |
Plasmodium knowlesi | PKNH_0003100 | U4/U6 small nuclear ribonucleoprotein PRP31, putative |
Plasmodium knowlesi | PKNH_0307100 | U4/U6 small nuclear ribonucleoprotein PRP31, putative |
Plasmodium vivax | PVX_000790 | U4/U6 small nuclear ribonucleoprotein PRP31, putative |
Plasmodium yoelii | PY04097 | Putative snoRNA binding domain, putative |
Saccharomyces cerevisiae | YGR091W | Prp31p |
Schistosoma japonicum | Sjp_0046230 | U4/U6 small nuclear ribonucleoprotein Prp31, putative |
Schistosoma mansoni | Smp_163030 | hypothetical protein |
Schmidtea mediterranea | mk4.014945.00 | U4/U6 small nuclear ribonucleoprotein Prp31 |
Schmidtea mediterranea | mk4.035350.00 | |
Trypanosoma brucei gambiense | Tbg972.10.12970 | trans-splicing factor, putative |
Trypanosoma brucei | Tb927.10.10700 | splicing factor Prp31 |
Trypanosoma congolense | TcIL3000_10_9000 | trans-splicing factor, putative |
Trypanosoma cruzi | TcCLB.504625.10 | trans-splicing factor, putative |
Trypanosoma cruzi | TcCLB.503583.40 | trans-splicing factor, putative |
Toxoplasma gondii | TGME49_244100 | snoRNA binding domain-containing protein |
Theileria parva | TP02_0595 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_224350 | prp31, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.10700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10700 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10700 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.10700 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y110A7A.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y110A7A.8 | Caenorhabditis elegans | sterile | wormbase |
YGR091W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1006700 this record | Plasmodium berghei | Essential | plasmo |
TGME49_244100 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.