pI: 8.4968 |
Length (AA): 180 |
MW (Da): 20214 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 176 | 3r90 (A) | 2 | 178 | 48.00 | 0 | 1 | 1.68668 | -1.36 |
85 | 156 | 2j5v (A) | 270 | 338 | 25.00 | 0 | 0.49 | 0.6193 | -0.08 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | 16 hs Trophozoite, Erthyrocytic stages. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Ookinete, 4 hs Ring, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Gametocyte, 22 hs Schizont. | Otto TD |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_127512)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09150 | pseudouridine synthase and archaeosine transglycosylase domain-containing protein |
Babesia bovis | BBOV_II005020 | cell cycle regulator protein, putative |
Brugia malayi | Bm1_36830 | hypothetical protein |
Candida albicans | CaO19.2920 | similar to S. cerevisiae YER007C-A |
Candida albicans | CaO19.10437 | similar to S. cerevisiae YER007C-A |
Caenorhabditis elegans | CELE_C11D2.7 | Protein C11D2.7 |
Cryptosporidium hominis | Chro.30448 | uncharacterized domain 2 |
Cryptosporidium parvum | cgd3_3970 | Yer007c-ap/MCT-1 like PUA RNA binding domain containing protein |
Dictyostelium discoideum | DDB_G0271910 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5941 | CG5941 gene product from transcript CG5941-RA |
Echinococcus granulosus | EgrG_000827900 | malignant t cell amplified sequence 1 |
Entamoeba histolytica | EHI_016460 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000827900 | malignant t cell amplified sequence 1 |
Giardia lamblia | GL50803_13897 | MCT-1 protein-like protein |
Homo sapiens | 28985 | malignant T cell amplified sequence 1 |
Leishmania braziliensis | LbrM.19.0140 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_110180.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.11.0180 | hypothetical protein, conserved |
Leishmania major | LmjF.11.0180 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.11.0180 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000042814 | malignant T cell amplified sequence 2 |
Mus musculus | ENSMUSG00000000355 | malignant T cell amplified sequence 1 |
Neospora caninum | NCLIV_005020 | PUA domain-containing, cell cycle regulator protein, putative |
Oryza sativa | 4327290 | Os01g0314300 |
Plasmodium berghei | PBANKA_1244000 | cell cycle regulator protein, putative |
Plasmodium falciparum | PF3D7_0529500 | cell cycle regulator protein, putative |
Plasmodium knowlesi | PKNH_1003300 | cell cycle regulator protein, putative |
Plasmodium vivax | PVX_079780 | cell cycle regulator protein, putative |
Plasmodium yoelii | PY02784 | uncharacterized domain 2, putative |
Saccharomyces cerevisiae | YER007C-A | Tma20p |
Schistosoma japonicum | Sjp_0200630 | ko:K07575 PUA domain protein, putative |
Schmidtea mediterranea | mk4.000618.03 | Putative beta-1,4-galactosyltransferase |
Trypanosoma brucei gambiense | Tbg972.11.8040 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.7100 | cytoplasmic translation machinery associated protein, putative |
Trypanosoma congolense | TcIL3000.11.7670 | cytoplasmic translation machinery associated protein, putative |
Trypanosoma cruzi | TcCLB.506777.20 | cytoplasmic translation machinery associated protein, putative |
Trypanosoma cruzi | TcCLB.511165.4 | cytoplasmic translation machinery associated protein, putative |
Toxoplasma gondii | TGME49_221490 | cell cycle regulator protein |
Theileria parva | TP04_0043 | cell cycle regulator protein, putative |
Trichomonas vaginalis | TVAG_342970 | ligatin translation initiation factor, putative |
Trichomonas vaginalis | TVAG_306110 | mct-1 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4950 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4950 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4950 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4950 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1244000 this record | Plasmodium berghei | Dispensable | plasmo |
TGME49_221490 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.