pI: 8.9492 |
Length (AA): 83 |
MW (Da): 9450 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 77 | 1th7 (A) | 2 | 78 | 30.00 | 0.000000000057 | 1 | 1.41276 | -1.15 |
10 | 73 | 1i4k (A) | 5 | 69 | 36.00 | 0.000044 | 1 | 1.32898 | -1.16 |
11 | 76 | 4m7d (F) | 27 | 104 | 38.00 | 0.000000045 | 1 | 1.36528 | -1.28 |
12 | 78 | 4f7u (G) | 5007 | 5074 | 49.00 | 0 | 1 | 1.49633 | -1.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Gametocyte, 22 hs Schizont, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ookinete. | Otto TD |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_128490)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G23930 | probable small nuclear ribonucleoprotein G |
Arabidopsis thaliana | AT3G11500 | small nuclear ribonucleoprotein G |
Babesia bovis | BBOV_II007600 | small nuclear ribonucleoprotein G, putative |
Brugia malayi | Bm1_11805 | small nuclear ribonucleoprotein G |
Caenorhabditis elegans | CELE_Y71F9B.4 | Protein SNR-7 |
Cryptosporidium parvum | cgd7_3970 | small nuclear ribonucleoprotein, putative |
Dictyostelium discoideum | DDB_G0282863 | LSM domain-containing protein |
Drosophila melanogaster | Dmel_CG9742 | Small ribonucleoprotein particle protein SmG |
Echinococcus granulosus | EgrG_000866000 | small nuclear ribonucleoprotein G |
Entamoeba histolytica | EHI_138790 | LSM domain containing protein |
Echinococcus multilocularis | EmuJ_000866000 | small nuclear ribonucleoprotein G |
Homo sapiens | ENSG00000143977 | small nuclear ribonucleoprotein polypeptide G |
Leishmania braziliensis | LbrM.32.1170 | small nuclear ribonucleoprotein, putative |
Leishmania donovani | LdBPK_321130.1 | small nuclear ribonucleoprotein, putative |
Leishmania infantum | LinJ.32.1130 | small nuclear ribonucleoprotein, putative |
Leishmania major | LmjF.32.1070 | small nuclear ribonucleoprotein, putative |
Leishmania mexicana | LmxM.31.1070 | small nuclear ribonucleoprotein, putative |
Loa Loa (eye worm) | LOAG_05564 | small nuclear ribonucleoprotein G |
Mus musculus | ENSMUSG00000057278 | small nuclear ribonucleoprotein polypeptide G |
Neospora caninum | NCLIV_057680 | hypothetical protein |
Oryza sativa | 4333092 | Os03g0410900 |
Oryza sativa | 4343870 | Os07g0608700 |
Plasmodium berghei | PBANKA_0708400 | small nuclear ribonucleoprotein G, putative |
Plasmodium falciparum | PF3D7_0822300 | small nuclear ribonucleoprotein G, putative |
Plasmodium knowlesi | PKNH_1316300 | small nuclear ribonucleoprotein G, putative |
Plasmodium vivax | PVX_089250 | small nuclear ribonucleoprotein G, putative |
Plasmodium yoelii | PY07229 | putative small nuclear ribonucleoprotein polypeptide G |
Saccharomyces cerevisiae | YFL017W-A | Smx2p |
Schistosoma japonicum | Sjp_0020550 | Probable small nuclear ribonucleoprotein G, putative |
Schistosoma mansoni | Smp_038680 | small nuclear ribonucleoprotein G (snrnp-G) |
Schmidtea mediterranea | mk4.000327.15 | Probable small nuclear ribonucleoprotein G |
Trypanosoma brucei gambiense | Tbg972.11.16030 | small nuclear ribonucleoprotein Sm-G,small nucleolar ribonucleoprotein-like protein |
Trypanosoma brucei | Tb927.11.14310 | small nuclear ribonucleoprotein Sm-G |
Trypanosoma cruzi | TcCLB.511725.174 | small nuclear ribonucleoprotein Sm-G, putative |
Toxoplasma gondii | TGME49_314790 | small nuclear ribonucleoprotein G, putative |
Theileria parva | TP02_0700 | small nuclear ribonucleoprotein G, putative |
Trichomonas vaginalis | TVAG_529870 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_076710 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_154450 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5915 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5915 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5915 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.5915 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y71F9B.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_Y71F9B.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y71F9B.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y71F9B.4 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y71F9B.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y71F9B.4 | Caenorhabditis elegans | sterile | wormbase |
YFL017W-A | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0708400 this record | Plasmodium berghei | Essential | plasmo |
TGME49_314790 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.