pI: 9.2948 |
Length (AA): 619 |
MW (Da): 70142 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 617 | 3bk7 (A) | 4 | 593 | 43.00 | 0 | 1 | 1.54449 | -0.64 |
54 | 96 | 5odq (A) | 569 | 605 | 46.00 | 0.69 | 0.13 | 0.177467 | 1.95 |
94 | 617 | 3ozx (A) | 76 | 595 | 40.00 | 0 | 1 | 1.41333 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Erthyrocytic stages. | Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Ookinete, 4 hs Ring, 16 hs Trophozoite. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Female gametocyte, Male gametocyte. | Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Gametocyte, 22 hs Schizont. | Otto TD |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_127149)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G19210 | RNAse l inhibitor protein 2 |
Arabidopsis thaliana | AT3G13640 | ABC transporter E family member 1 |
Babesia bovis | BBOV_III009450 | ABC transporter, ATP-binding domain containing protein |
Brugia malayi | Bm1_15645 | ATP-binding cassette sub-family E member 1 (Ribonuclease 4 inhibitor) |
Candida albicans | CaO19.10552 | RNAse L inhibitor-type ATP binding cassette protein similar to S. cerevisiae RLI1 (YDR091C) and to mammalian BCRP transporter |
Candida albicans | CaO19.3034 | RNAse L inhibitor-type ATP binding cassette protein similar to S. cerevisiae RLI1 (YDR091C) and to mammalian BCRP transporter |
Caenorhabditis elegans | CELE_Y39E4B.1 | Protein ABCE-1 |
Cryptosporidium hominis | Chro.10119 | RNase L inhibitor-like protein |
Cryptosporidium parvum | cgd1_980 | RNase L inhibitor-like protein |
Dictyostelium discoideum | DDB_G0290483 | 4Fe-4S ferredoxin, iron-sulfur binding domain-containing protein |
Drosophila melanogaster | Dmel_CG5651 | pixie |
Echinococcus granulosus | EgrG_001052900 | ATP binding cassette sub family E |
Entamoeba histolytica | EHI_156200 | RNAseL inhibitor-like protein, putative |
Echinococcus multilocularis | EmuJ_001052900 | ATP binding cassette sub family E |
Giardia lamblia | GL50803_7662 | RNase L inhibitor |
Homo sapiens | ENSG00000164163 | ATP-binding cassette, sub-family E (OABP), member 1 |
Leishmania braziliensis | LbrM.21.0770 | ribonuclease L inhibitor, putative,ATP-binding cassette sub-family E, putative |
Leishmania donovani | LdBPK_210770.1 | ATP-binding cassette protein subfamily E, member 1, putative |
Leishmania infantum | LinJ.21.0770 | ATP-binding cassette protein subfamily E, member 1, putative |
Leishmania major | LmjF.21.0710 | ATP-binding cassette protein subfamily E, member 1, putative |
Leishmania mexicana | LmxM.21.0710 | ribonuclease L inhibitor, putative,ATP-binding cassette sub-family E, putative |
Loa Loa (eye worm) | LOAG_04200 | ATP-binding cassette subfamily E |
Mus musculus | ENSMUSG00000058355 | ATP-binding cassette, sub-family E (OABP), member 1 |
Neospora caninum | NCLIV_059510 | RNase L inhibitor, related |
Oryza sativa | 4350692 | Os11g0546000 |
Oryza sativa | 4329031 | Os02g0282900 |
Plasmodium berghei | PBANKA_1144100 | ABC transporter E family member 1, putative |
Plasmodium falciparum | PF3D7_1368200 | ABC transporter E family member 1, putative |
Plasmodium knowlesi | PKNH_1103000 | ABC transporter E family member 1, putative |
Plasmodium vivax | PVX_115370 | ABC transporter E family member 1, putative |
Plasmodium yoelii | PY04219 | 68 kDa protein |
Saccharomyces cerevisiae | YDR091C | Rli1p |
Schistosoma japonicum | Sjp_0011870 | ko:K06174 ATP-binding cassette, sub-family E, member 1, putative |
Schistosoma mansoni | Smp_124460 | ATP-binding cassette sub-family E (oabp) member |
Trypanosoma brucei gambiense | Tbg972.10.1920 | ribonuclease L inhibitor, putative,ATP-binding cassette sub-family E, putative |
Trypanosoma brucei | Tb927.10.1630 | atp-binding cassette sub-family e member 1 |
Trypanosoma congolense | TcIL3000_10_1400 | ribonuclease L inhibitor, putative |
Trypanosoma cruzi | TcCLB.508637.150 | ribonuclease L inhibitor, putative |
Toxoplasma gondii | TGME49_216790 | ATP-binding cassette sub-family E member 1, putative |
Theileria parva | TP04_0855 | RNAse L inhibitor, putative |
Trichomonas vaginalis | TVAG_249850 | RNAse L inhibitor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1630 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1630 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1630 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y39E4B.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y39E4B.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y39E4B.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y39E4B.1 | Caenorhabditis elegans | sterile | wormbase |
YDR091C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1144100 this record | Plasmodium berghei | Essential | plasmo |
TGME49_216790 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.