pI: 10.0302 |
Length (AA): 266 |
MW (Da): 31839 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 261 | 4arf (A) | 454 | 702 | 14.00 | 0 | 0.06 | 1.04428 | -0.03 |
58 | 87 | 2mxv (A) | 9 | 40 | 50.00 | 0.17 | 1 | 0.562782 | 0.82 |
182 | 254 | 2y8d (A) | 2524 | 2596 | 27.00 | 0.95 | 0.03 | 0.744436 | -2.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Ookinete, 4 hs Ring, Erthyrocytic stages. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | 16 hs Trophozoite, Female gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Gametocyte, 22 hs Schizont. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Male gametocyte. | Yeoh LM |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Ortholog group members (OG5_131371)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_I000380 | conserved hypothetical protein |
Brugia malayi | Bm1_26850 | Zn-finger in Ran binding protein and others containing protein |
Caenorhabditis elegans | CELE_Y25C1A.8 | Protein Y25C1A.8, isoform A |
Drosophila melanogaster | Dmel_CG3732 | CG3732 gene product from transcript CG3732-RA |
Echinococcus granulosus | EgrG_001117200 | zinc finger protein Ran binding |
Echinococcus multilocularis | EmuJ_001117200 | zinc finger protein Ran binding |
Homo sapiens | ENSG00000132485 | zinc finger, RAN-binding domain containing 2 |
Loa Loa (eye worm) | LOAG_07588 | hypothetical protein |
Mus musculus | ENSMUSG00000028180 | zinc finger, RAN-binding domain containing 2 |
Neospora caninum | NCLIV_061180 | zinc finger, putative |
Onchocerca volvulus | OVOC11086 |
|
Plasmodium berghei | PBANKA_1005900 | zinc finger Ran-binding domain-containing protein 2, putative |
Plasmodium falciparum | PF3D7_0408300 | zinc finger Ran-binding domain-containing protein 2, putative |
Plasmodium knowlesi | PKNH_0306300 | zinc finger Ran-binding domain-containing protein 2, putative |
Plasmodium vivax | PVX_000830 | hypothetical protein, conserved |
Plasmodium yoelii | PY02236 | hypothetical protein |
Schistosoma japonicum | Sjp_0086520 | Zinc finger Ran-binding domain-containing protein 2, putative |
Schistosoma mansoni | Smp_082560.1 | zinc finger protein |
Schmidtea mediterranea | mk4.000124.09 | |
Schmidtea mediterranea | mk4.001196.00 | |
Toxoplasma gondii | TGME49_219300 | ran binding protein |
Theileria parva | TP02_0913 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1005900 this record | Plasmodium berghei | Dispensable | plasmo |
TGME49_219300 | Toxoplasma gondii | Probably non-essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.