pI: 10.1857 |
Length (AA): 654 |
MW (Da): 76978 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
169 | 332 | 4rz9 (A) | 3 | 164 | 25.00 | 0.000023 | 1 | 0.649865 | -1.06 |
174 | 335 | 5f5t (A) | 20 | 183 | 18.00 | 0 | 1 | 0.618406 | -1.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Ookinete, 4 hs Ring, 16 hs Trophozoite, Erthyrocytic stages. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Gametocyte, 22 hs Schizont, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_130216)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_III008900 | PRP38 family protein |
Brugia malayi | Bm1_20635 | PRP38 family protein |
Caenorhabditis elegans | CELE_Y108G3AL.2 | Protein Y108G3AL.2 |
Dictyostelium discoideum | DDB_G0288401 | pre-mRNA processing factor 38 |
Drosophila melanogaster | Dmel_CG1622 | CG1622 gene product from transcript CG1622-RC |
Escherichia coli | b4487 | putative periplasmic protein |
Echinococcus granulosus | EgrG_000216600 | pre mRNA splicing factor 38B |
Entamoeba histolytica | EHI_083650 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000216600 | pre mRNA splicing factor 38B |
Homo sapiens | ENSG00000134186 | pre-mRNA processing factor 38B |
Loa Loa (eye worm) | LOAG_11666 | PRP38 family protein |
Mus musculus | ENSMUSG00000027881 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing B |
Neospora caninum | NCLIV_014960 | hypothetical protein |
Oryza sativa | 4337972 | Os05g0178900 |
Plasmodium berghei | PBANKA_1034900 | pre-mRNA-splicing factor 38B, putative |
Plasmodium falciparum | PF3D7_1407300 | pre-mRNA-splicing factor 38B, putative |
Plasmodium knowlesi | PKNH_1350800 | pre-mRNA-splicing factor 38B, putative |
Plasmodium vivax | PVX_086065 | pre-mRNA-splicing factor 38B, putative |
Plasmodium yoelii | PY02472 | hypothetical protein |
Schistosoma japonicum | Sjp_0216490 | Pre-mRNA-splicing factor 38B, putative |
Schistosoma mansoni | Smp_133110 | hypothetical protein |
Schmidtea mediterranea | mk4.003482.14 | Pre-mRNA-splicing factor 38B |
Schmidtea mediterranea | mk4.005830.08 | Pre-mRNA-splicing factor 38B |
Toxoplasma gondii | TGME49_285230 | PRP38 family protein |
Theileria parva | TP04_0792 | hypothetical protein, conserved |
Theileria parva | TP04_0793 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b4487 | Escherichia coli | non-essential | goodall |
PBANKA_1034900 this record | Plasmodium berghei | Slow | plasmo |
TGME49_285230 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.