pI: 8.8873 |
Length (AA): 118 |
MW (Da): 13576 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 88 | 3tbn (A) | 3 | 79 | 44.00 | 0 | 0.92 | 1.17349 | -0.18 |
20 | 56 | 3tbo (A) | 12 | 47 | 45.00 | 0 | 0.95 | 0.687259 | -0.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Gametocyte, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Ookinete. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | 4 hs Ring. | Otto TD |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_131688)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_II006940 | hypothetical protein |
Brugia malayi | Bm1_45735 | RE40412p |
Brugia malayi | Bm1_09040 | RE40412p |
Caenorhabditis elegans | CELE_M88.7 | Protein M88.7 |
Caenorhabditis elegans | CELE_Y67D2.3 | Protein Y67D2.3 |
Dictyostelium discoideum | DDB_G0274303 | hypothetical protein |
Dictyostelium discoideum | DDB_G0267712 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3420 | CG3420 gene product from transcript CG3420-RA |
Echinococcus granulosus | EgrG_000627020 | conserved hypothetical protein |
Echinococcus multilocularis | EmuJ_000627020 | conserved hypothetical protein |
Homo sapiens | 284106 | CDGSH iron sulfur domain 3 |
Leishmania braziliensis | LbrM.34.1290 | hypothetical protein, unknown function |
Leishmania donovani | LdBPK_351380.1 | Iron-binding zinc finger CDGSH type, putative |
Leishmania infantum | LinJ.35.1380 | hypothetical protein, unknown function |
Leishmania major | LmjF.35.1370 | hypothetical protein, unknown function |
Leishmania mexicana | LmxM.34.1370 | hypothetical protein, unknown function |
Loa Loa (eye worm) | LOAG_11864 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04015 | hypothetical protein |
Mus musculus | 100504524 | predicted gene, 20267 |
Mus musculus | ENSMUSG00000078695 | CDGSH iron sulfur domain 3 |
Neospora caninum | NCLIV_008340 | AGAP004885-PA, related |
Onchocerca volvulus | OVOC7879 |
|
Onchocerca volvulus | OVOC8058 |
|
Plasmodium berghei | PBANKA_0507100 | CDGSH iron-sulfur domain-containing protein, putative |
Plasmodium falciparum | PF3D7_1022900 | CDGSH iron-sulfur domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0607200 | CDGSH iron-sulfur domain-containing protein, putative |
Plasmodium vivax | PVX_111570 | hypothetical protein, conserved |
Plasmodium yoelii | PY01665 | hypothetical protein |
Schistosoma japonicum | Sjp_0066920 | ko:K00271 putative glutamate synthetas [EC:1.4.1.-], putative |
Schistosoma japonicum | Sjp_0066910 | IPR012336,Thioredoxin-like fold,domain-containing |
Schistosoma mansoni | Smp_157700 | hypothetical protein |
Toxoplasma gondii | TGME49_254030 | zinc finger CDGSH-type domain-containing protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0507100 this record | Plasmodium berghei | Essential | plasmo |
TGME49_254030 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.