Detailed view for PBANKA_0708100

Basic information

TDR Targets ID: 829230
Plasmodium berghei, dynein light chain 1
Source Database / ID: 

pI: 8.4627 | Length (AA): 198 | MW (Da): 22888 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14580   Leucine-rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 192 1ds9 (A) 1 192 43.00 0 1 1.49129 -0.52
46 181 1d0b (A) 92 218 35.00 0.0000003 1 1.17967 -1.23
48 160 4fmz (A) 250 360 28.00 0.00052 1 1.07251 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Gametocyte, 22 hs Schizont, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile 4 hs Ring, Erthyrocytic stages. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Ookinete. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile 16 hs Trophozoite. Otto TD
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_129790)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG8800   CG8800 gene product from transcript CG8800-RA
Drosophila melanogaster Dmel_CG10839   CG10839 gene product from transcript CG10839-RB
Echinococcus granulosus EgrG_000448800   dynein light chain
Echinococcus multilocularis EmuJ_000448800   dynein light chain
Giardia lamblia GL50803_4463   Dynein light chain
Homo sapiens ENSG00000119661   dynein, axonemal, light chain 1
Leishmania braziliensis LbrM.24.1040   dynein light chain, putative
Leishmania donovani LdBPK_241050.1   dynein light chain, putative
Leishmania infantum LinJ.24.1050   dynein light chain, putative
Leishmania major LmjF.24.1030   dynein light chain, putative
Leishmania mexicana LmxM.24.1030   dynein light chain, putative
Mus musculus ENSMUSG00000042523   dynein, axonemal, light chain 1
Neospora caninum NCLIV_014880   hypothetical protein
Oryza sativa 4339238   Os05g0501600
Plasmodium berghei PBANKA_0708100   dynein light chain 1
Plasmodium falciparum PF3D7_0822500   dynein light chain 1
Plasmodium knowlesi PKNH_1316500   dynein light chain 1, putative
Schistosoma japonicum Sjp_0216100   ko:K10411 dynein light chain 1, axonemal, putative
Schistosoma mansoni Smp_160330   dynein light chain
Schmidtea mediterranea mk4.008733.01   Dynein light chain 1, axonemal
Trypanosoma brucei gambiense Tbg972.11.6400   dynein light chain, putative
Trypanosoma brucei Tb927.11.5680   dynein light chain 1, axonemal
Trypanosoma congolense TcIL3000_0_24600   dynein light chain, putative
Trypanosoma congolense TcIL3000.11.6050   dynein light chain, putative
Trypanosoma cruzi TcCLB.506203.20   dynein light chain, putative
Trypanosoma cruzi TcCLB.508645.30   dynein light chain, putative
Toxoplasma gondii TGME49_285350   dynein light chain, putative
Trichomonas vaginalis TVAG_447870   dynein light chain, putative

Essentiality

PBANKA_0708100 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3390 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.3390 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3390 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0708100 this record Plasmodium berghei Dispensable plasmo
TGME49_285350 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PBANKA_0708100 (Plasmodium berghei), dynein light chain 1
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