pI: 10.0212 |
Length (AA): 268 |
MW (Da): 31108 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 115 | 3l11 (A) | 0 | 88 | 17.00 | 0.04 | 0.29 | 0.493927 | -0.21 |
43 | 75 | 5din (A) | 31 | 62 | 50.00 | 0.28 | 1 | 0.641734 | 0.45 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Ookinete, 4 hs Ring, Male gametocyte. | Otto TD Yeoh LM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Gametocyte, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte. | Otto TD Yeoh LM |
Yeoh LM | Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates. |
Otto TD | A comprehensive evaluation of rodent malaria parasite genomes and gene expression. |
Ortholog group members (OG5_129487)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G61620 | zinc Finger RING C3H2C3-type protein |
Babesia bovis | BBOV_II003220 | conserved hypothetical protein |
Brugia malayi | Bm1_20435 | CG6179-PA |
Caenorhabditis elegans | CELE_R05G6.4 | Protein R05G6.4 |
Dictyostelium discoideum | DDB_G0270882 | hypothetical protein |
Drosophila melanogaster | Dmel_CG6179 | CG6179 gene product from transcript CG6179-RA |
Echinococcus granulosus | EgrG_000625000 | nitric oxide synthase interacting protein |
Echinococcus multilocularis | EmuJ_000625300 | nitric oxide synthase interacting protein |
Echinococcus multilocularis | EmuJ_000625000 | nitric oxide synthase interacting protein |
Homo sapiens | ENSG00000142546 | nitric oxide synthase interacting protein |
Loa Loa (eye worm) | LOAG_08646 | hypothetical protein |
Mus musculus | ENSMUSG00000003421 | nitric oxide synthase interacting protein |
Neospora caninum | NCLIV_067510 | hypothetical protein, conserved |
Oryza sativa | 4332437 | Os03g0279900 |
Plasmodium berghei | PBANKA_1232800 | NOSIP domain-containing protein, putative |
Plasmodium falciparum | PF3D7_0518000 | NOSIP domain-containing protein, putative |
Plasmodium knowlesi | PKNH_1015200 | NOSIP domain-containing protein, putative |
Plasmodium yoelii | PY01617 | hypothetical protein |
Schistosoma japonicum | Sjp_0303900 | Nitric oxide synthase-interacting protein, putative |
Schistosoma mansoni | Smp_090830 | nitric oxide synthase interacting protein |
Schmidtea mediterranea | mk4.002255.01 | Nitric oxide synthase-interacting protein homolog |
Schmidtea mediterranea | mk4.018825.00 | Nitric oxide synthase-interacting protein homolog |
Toxoplasma gondii | TGME49_278490 | Zn-finger, RING domain containing protein |
Theileria parva | TP04_0271 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_322550 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1232800 this record | Plasmodium berghei | Dispensable | plasmo |
TGME49_278490 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.