Detailed view for PF3D7_1202300

Basic information

TDR Targets ID: 829609
Plasmodium falciparum, dynein heavy chain, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4174 | Length (AA): 5718 | MW (Da): 690136 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
865 1717 3ibv (A) 68 974 12.00 0 0.78 -0.030722 0.88
898 1857 3icq (T) 35 975 12.00 0 0.96 -0.0300091 0.98
1228 2108 1z3h (B) 34 953 12.00 0 0.84 -0.0138251 0.74
1642 4163 3vkg (A) 1450 4162 13.00 0 1 0.225163 0.77
1723 4273 3vkh (A) 1512 4040 14.00 0 1 0.216235 0.91
3416 3688 3i9w (A) 40 306 8.00 0 0.01 -0.010156 -1.28
3753 4776 3gjx (A) 15 1055 14.00 0 0.88 0.0381836 0.74
3997 5285 4rh7 (A) 2891 4060 22.00 0.000000000039 1 0.127428 1.51
5175 5424 4wat (A) 202 459 31.00 0.49 0.08 -0.229278 1.94
898 1857 3icq (T) 35 975 12.00 0 1 -0.0262504 0.99
1601 2054 4fp7 (B) 41 475 14.00 0 0.85 -0.213774 0.8
1642 4160 3vkg (A) 1450 4162 13.00 0 1 0.223493 0.79
1723 4270 3vkh (A) 1512 4040 14.00 0 1 0.215566 0.92
3413 3685 3i9w (A) 40 306 8.00 0 0.01 -0.00943933 -1.28
3804 4632 3ffz (A) 366 1212 24.00 0.00011 0.99 0.0741315 1.83
3951 5277 3vkh (A) 3259 4437 20.00 0.000000049 1 0.179255 0.96
4200 4637 4a3t (A) 9 464 13.00 0 0.25 -0.089573 0.43
5173 5422 4wat (A) 202 459 31.00 0.5 0.08 -0.229163 1.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst, Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_138829)

Species Accession Gene Product
Plasmodium berghei PBANKA_0601200   dynein heavy chain, putative
Plasmodium falciparum PF3D7_1202300   dynein heavy chain, putative
Plasmodium knowlesi PKNH_1302200   dynein heavy chain, putative
Plasmodium vivax PVX_084160   dynein heavy chain, putative
Plasmodium yoelii PY04932   hypothetical protein
Plasmodium yoelii PY00464   hypothetical protein
Plasmodium yoelii PY01526   rhoptry protein

Essentiality

PF3D7_1202300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0601200 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1202300 (Plasmodium falciparum), dynein heavy chain, putative
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