Detailed view for PF3D7_0111000

Basic information

TDR Targets ID: 829611
Plasmodium falciparum, kinesin-8, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.2934 | Length (AA): 1664 | MW (Da): 191873 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00225   Kinesin motor domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008017   microtubule binding  
GO:0005524   ATP binding  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 879 3v0a (B) 290 1150 23.00 0.0000053 1 0.404641 1.42
921 1307 4frz (B) 884 1247 37.00 0 1 0.574372 -0.41
925 1265 3lre (B) 10 355 50.00 0 1 0.765728 -1
972 1264 4etp (A) 428 722 36.00 0.14 1 0.611682 -0.68
973 1264 4h1g (A) 397 682 40.00 0 1 0.626281 -0.9
979 1265 3bfn (A) 87 368 43.00 0 1 0.526276 -0.23
1456 1638 4uos (A) 2 184 22.00 0.019 0.41 0.379576 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Oocyst, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127280)

Species Accession Gene Product
Arabidopsis thaliana AT1G18550   ATP binding microtubule motor family protein
Arabidopsis thaliana AT3G49650   P-loop containing nucleoside triphosphate hydrolase-like protein
Babesia bovis BBOV_IV003380   kinesin, putative
Candida albicans CaO19.7353   kinesin motor domain protein
Cryptosporidium hominis Chro.30351   similar to protein FLJ37300
Cryptosporidium parvum cgd3_3090   conserved hypothetical protein
Dictyostelium discoideum DDB_G0293198   kinesin family member 10
Drosophila melanogaster Dmel_CG9913   Kinesin family member 19A ortholog
Drosophila melanogaster Dmel_CG10923   Kinesin-like protein at 67A
Giardia lamblia GL50803_4371   Kinesin-8
Homo sapiens ENSG00000186185   kinesin family member 18B
Homo sapiens ENSG00000121621   kinesin family member 18A
Homo sapiens ENSG00000196169   kinesin family member 19
Mus musculus ENSMUSG00000010021   kinesin family member 19A
Mus musculus 101055939   kinesin-like protein KIF19-like
Mus musculus ENSMUSG00000027115   kinesin family member 18A
Mus musculus ENSMUSG00000051378   kinesin family member 18B
Neospora caninum NCLIV_007650   hypothetical protein
Neospora caninum NCLIV_065120   kinesin motor domain-containing protein, putative
Oryza sativa 4334272   Os03g0773600
Oryza sativa 4324211   Os01g0605500
Plasmodium berghei PBANKA_0202700   kinesin-8, putative
Plasmodium berghei PBANKA_0805900   kinesin-8, putative
Plasmodium falciparum PF3D7_0319400   kinesin-8, putative
Plasmodium falciparum PF3D7_0111000   kinesin-8, putative
Plasmodium knowlesi PKNH_0202500   kinesin-8, putative
Plasmodium knowlesi PKNH_0821800   kinesin-8, putative
Plasmodium vivax PVX_081250   kinesin-8, putative
Plasmodium vivax PVX_095265   kinesin-8, putative
Plasmodium yoelii PY00972   kinesin-related protein
Plasmodium yoelii PY02372   kinesin-like protein-related
Saccharomyces cerevisiae YGL216W   tubulin-dependent ATPase KIP3
Schmidtea mediterranea mk4.008703.00  
Toxoplasma gondii TGME49_253110   kinesin motor domain-containing protein
Toxoplasma gondii TGME49_249020   kinesin motor domain-containing protein
Theileria parva TP01_1097   kinesin, putative
Trichomonas vaginalis TVAG_447880   conserved hypothetical protein
Trichomonas vaginalis TVAG_395330   kinesin eg-5, putative

Essentiality

PF3D7_0111000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0202700 Plasmodium berghei Dispensable plasmo
PBANKA_0805900 Plasmodium berghei Dispensable plasmo
TGME49_253110 Toxoplasma gondii Probably non-essential sidik
TGME49_249020 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0111000 (Plasmodium falciparum), kinesin-8, putative
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