pI: 9.0186 |
Length (AA): 447 |
MW (Da): 52971 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 117 | 3fp2 (A) | 143 | 270 | 33.00 | 0.97 | 0.09 | 0.310196 | 1.27 |
66 | 447 | 2y1h (A) | 5 | 269 | 27.00 | 0 | 1 | 0.518386 | 0.68 |
67 | 446 | 2xio (A) | 4 | 296 | 41.00 | 0 | 1 | 0.939912 | 0.12 |
69 | 443 | 3ipw (A) | 5 | 297 | 40.00 | 0 | 1 | 0.982326 | 0.32 |
219 | 362 | 1yix (A) | 70 | 208 | 29.00 | 0.00017 | 1 | 0.661548 | -0.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 24 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_126665)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G52390 | TatD related DNase |
Babesia bovis | BBOV_II007740 | hydrolase, TatD family protein |
Brugia malayi | Bm1_12370 | hydrolase, TatD family protein |
Candida albicans | CaO19.10075 | similar to S. cerevisiae YBL055C |
Candida albicans | CaO19.2541 | similar to S. cerevisiae YBL055C |
Caenorhabditis elegans | CELE_Y24F12A.1 | Protein Y24F12A.1 |
Caenorhabditis elegans | CELE_CD4.2 | Protein CRN-2 |
Caenorhabditis elegans | CELE_B0432.8 | Protein B0432.8 |
Caenorhabditis elegans | CELE_Y37H2A.1 | Protein Y37H2A.1, isoform B |
Cryptosporidium hominis | Chro.60037 | CG3358-PB |
Cryptosporidium parvum | cgd6_250 | hypothetical protein |
Chlamydia trachomatis | CT_594 | PHP superfamily hydrolase |
Dictyostelium discoideum | DDB_G0278649 | hypothetical protein |
Dictyostelium discoideum | DDB_G0269630 | TatD-related deoxyribonuclease |
Dictyostelium discoideum | DDB_G0282531 | tatD-related DNAse |
Drosophila melanogaster | Dmel_CG3358 | CG3358 gene product from transcript CG3358-RF |
Drosophila melanogaster | Dmel_CG3308 | CG3308 gene product from transcript CG3308-RA |
Escherichia coli | b4378 | putative DNase |
Escherichia coli | b1100 | putative DNase |
Escherichia coli | b4483 | quality control of Tat-exported FeS proteins |
Echinococcus granulosus | EgrG_001041600 | deoxyribonuclease TATDN1 |
Entamoeba histolytica | EHI_050300 | hydrolase TatD family protein |
Entamoeba histolytica | EHI_119490 | hydrolase TatD family protein |
Echinococcus multilocularis | EmuJ_001041600 | deoxyribonuclease TATDN1 |
Giardia lamblia | GL50803_95789 | Deoxyribonuclease, TatD family |
Homo sapiens | ENSG00000203705 | TatD DNase domain containing 3 |
Homo sapiens | ENSG00000157014 | TatD DNase domain containing 2 |
Homo sapiens | ENSG00000147687 | TatD DNase domain containing 1 |
Leishmania braziliensis | LbrM.11.1030 | tatD related deoxyribonuclease, putative |
Leishmania donovani | LdBPK_111270.1 | tatD related deoxyribonuclease, putative |
Leishmania infantum | LinJ.11.1270 | tatD related deoxyribonuclease, putative |
Leishmania major | LmjF.11.1280 | tatD related deoxyribonuclease, putative |
Leishmania mexicana | LmxM.11.1280 | tatD related deoxyribonuclease, putative |
Loa Loa (eye worm) | LOAG_07803 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13580 | hydrolase |
Mycobacterium leprae | ML0239 | Probable deoxyribonuclease TatD |
Mus musculus | ENSMUSG00000026632 | TatD DNase domain containing 3 |
Mus musculus | ENSMUSG00000050891 | TatD DNase domain containing 1 |
Mus musculus | ENSMUSG00000056952 | TatD DNase domain containing 2 |
Mycobacterium tuberculosis | Rv1008 | Probable deoxyribonuclease TatD (YJJV protein) |
Mycobacterium ulcerans | MUL_4653 | deoxyribonuclease TatD |
Neospora caninum | NCLIV_007610 | GF17261, related |
Oryza sativa | 9270278 | Os08g0165800 |
Oryza sativa | 4342437 | Os07g0158200 |
Plasmodium berghei | PBANKA_0201800 | TatD-like deoxyribonuclease |
Plasmodium falciparum | PF3D7_0112000 | TatD-like deoxyribonuclease |
Plasmodium knowlesi | PKNH_0201600 | TatD-like deoxyribonuclease, putative |
Plasmodium yoelii | PY01446 | hydrolase, TatD family |
Saccharomyces cerevisiae | YBL055C | 3'-5'-exodeoxyribonuclease |
Schistosoma japonicum | Sjp_0205520 | ko:K03424 Mg-dependent DNase, putative |
Schistosoma mansoni | Smp_147810 | tatd dnase-related |
Schistosoma mansoni | Smp_000810.2 | tatd dnase-related |
Schistosoma mansoni | Smp_000810.1 | similar to TatD DNase domain containing 1 |
Schmidtea mediterranea | mk4.011965.00 | Putative deoxyribonuclease TATDN1 |
Trypanosoma brucei gambiense | Tbg972.11.6850 | tatD related deoxyribonuclease, putative |
Trypanosoma brucei | Tb11.v5.0746 | tatD related deoxyribonuclease, putative |
Trypanosoma congolense | TcIL3000.11.6620 | tatD related deoxyribonuclease, putative |
Trypanosoma cruzi | TcCLB.504149.40 | tatD related deoxyribonuclease, putative |
Toxoplasma gondii | TGME49_253070 | hydrolase, TatD family protein |
Treponema pallidum | TP0979 | hypothetical protein |
Treponema pallidum | TP0994 | hypothetical protein |
Theileria parva | TP02_0686 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_481040 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_230160 | conserved hypothetical protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0245 | Mg-dependent Dnase, TadD |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3920 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3920 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3920 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.3920 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1100 | Escherichia coli | non-essential | goodall |
b4483 | Escherichia coli | non-essential | goodall |
b4378 | Escherichia coli | non-essential | goodall |
TGME49_253070 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.