Detailed view for PF3D7_0933200

Basic information

TDR Targets ID: 829799
Plasmodium falciparum, calcyclin-binding protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.0707 | Length (AA): 200 | MW (Da): 23999 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04969   CS domain
PF05002   SGS domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 113 2xcm (C) 150 239 20.00 0.000000014 0.51 0.7345 -0.45
23 115 1rl1 (A) 138 229 26.00 0.000000000088 0.93 0.8225 -0.21
150 180 2jtt (C) 189 219 42.00 0.067 0.3 0.5973 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 16 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 8 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127963)

Species Accession Gene Product
Arabidopsis thaliana AT4G11260   phosphatase SGT1b
Arabidopsis thaliana AT4G23570   phosphatase SGT1a
Brugia malayi Bm1_21075   SGS domain containing protein
Candida albicans CaO19.11570   similar to S. cerevisiae SGT1 subunit of SCF ubiquitin ligase complex
Candida albicans CaO19.4089   similar to S. cerevisiae SGT1 subunit of SCF ubiquitin ligase complex
Caenorhabditis elegans CELE_D1054.3   Protein D1054.3, isoform B
Dictyostelium discoideum DDB_G0269292   SGS domain-contantaing protein
Drosophila melanogaster Dmel_CG9617   suppressor-of-G2-allele-of-skp1
Echinococcus granulosus EgrG_001006400   Suppressor of G2 allele of SKP1
Entamoeba histolytica EHI_117820   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001006400   Suppressor of G2 allele of SKP1
Giardia lamblia GL50803_7850   Sgt1-like protein
Homo sapiens 10910   SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Leishmania braziliensis LbrM.20.5800   phosphatase-like protein
Leishmania donovani LdBPK_201610.1   Suppressor of G2 allele of SKP1, putative
Leishmania infantum LinJ.20.1610   phosphatase-like protein
Leishmania major LmjF.20.1640   phosphatase-like protein
Leishmania mexicana LmxM.20.1640   phosphatase-like protein
Loa Loa (eye worm) LOAG_08244   hypothetical protein
Mus musculus ENSMUSG00000022024   SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Neospora caninum NCLIV_031740   GJ10617, related
Oryza sativa 4326682   Os01g0624500
Onchocerca volvulus OVOC7546   Putative chaperone binding protein
Plasmodium berghei PBANKA_0834000   calcyclin-binding protein, putative
Plasmodium falciparum PF3D7_0933200   calcyclin-binding protein, putative
Plasmodium knowlesi PKNH_0731900   calcyclin-binding protein, putative
Plasmodium vivax PVX_087045   SGS domain containing protein
Saccharomyces cerevisiae YOR057W   Sgt1p
Schistosoma japonicum Sjp_0056120   Suppressor of G2 allele of SKP1 homolog, putative
Schistosoma mansoni Smp_010160   chaperone binding protein
Schistosoma mansoni Smp_168350   chaperone binding protein
Schmidtea mediterranea mk4.000280.10  
Trypanosoma brucei gambiense Tbg972.1.1960   phosphatase-like protein, putative
Trypanosoma brucei Tb927.1.3200   Suppressor of G2 allele of SKP1, putative
Trypanosoma congolense TcIL3000_1_1550   Suppressor of G2 allele of SKP1, putative
Trypanosoma cruzi TcCLB.508405.30   Suppressor of G2 allele of SKP1, putative
Trypanosoma cruzi TcCLB.507837.60   Suppressor of G2 allele of SKP1, putative
Toxoplasma gondii TGME49_231590   SGS domain-containing protein
Theileria parva TP04_0559   hypothetical protein
Trichomonas vaginalis TVAG_324510   chaperone binding protein, putative
Trichomonas vaginalis TVAG_078170   chaperone binding protein, putative

Essentiality

PF3D7_0933200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.3200 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.3200 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.3200 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.3200 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D1054.3 Caenorhabditis elegans embryonic lethal wormbase
YOR057W Saccharomyces cerevisiae inviable yeastgenome
TGME49_231590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0933200 (Plasmodium falciparum), calcyclin-binding protein, putative
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