Detailed view for PF3D7_0107800

Basic information

TDR Targets ID: 829876
Plasmodium falciparum, double-strand break repair protein MRE11
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.3477 | Length (AA): 1233 | MW (Da): 146148 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04152   Mre11 DNA-binding presumed domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0004519   endonuclease activity  
GO:0030145   manganese ion binding  
GO:0006302   double-strand break repair  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 331 3v0a (B) 788 1190 28.00 0.00033 0.49 0.194196 0.99
674 926 4fbk (B) 1092 1354 36.00 0 1 0.525191 0.63
684 920 4fcx (B) 99 349 42.00 0 1 0.448014 1.14
697 932 3t1i (A) 120 360 41.00 0 1 0.569203 0.62
1027 1212 4uos (A) 1 184 9.00 0.0006 0 0.344152 -1.47
6 315 3v0a (B) 788 1182 29.00 0.0031 0.54 0.140025 1.08
16 202 3uau (A) 81 259 30.00 0.14 0.08 0.194957 0.76
658 912 4fbk (B) 1092 1356 36.00 0 1 0.540732 0.52
668 904 4fcx (B) 99 349 42.00 0 1 0.450041 1.14
675 926 3t1i (A) 96 370 38.00 0 1 0.532267 0.58
1030 1215 4uos (A) 1 183 11.00 0.0077 0.03 0.290035 -1.14
23 176 4uos (A) 20 176 16.00 0.014 0.03 0.38897 -1.04
293 376 4tql (A) 83 173 33.00 0.63 0.05 0.273874 -0.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127969)

Species Accession Gene Product
Arabidopsis thaliana AT5G54260   double-strand break repair protein MRE11
Babesia bovis BBOV_III007250   DNA repair protein (mre11) family protein
Brugia malayi Bm1_21560   double-strand break repair protein mre-11
Candida albicans CaO19_6915   hypothetical protein
Candida albicans CaO19.6915   meiotic recombination complex
Caenorhabditis elegans CELE_ZC302.1   Protein MRE-11
Cryptosporidium hominis Chro.10164   DNA repair and meiosis protein Mre11 (emb
Cryptosporidium parvum cgd1_1420   DNA repair and meiosis protein Mre11 (emb
Dictyostelium discoideum DDB_G0293546   3'-5' exonuclease
Drosophila melanogaster Dmel_CG16928   meiotic recombination 11
Echinococcus granulosus EgrG_000145400   double strand break repair protein MRE11A
Entamoeba histolytica EHI_125910   double-strand break repair protein MRE11, putative
Echinococcus multilocularis EmuJ_000145400   double strand break repair protein MRE11A
Echinococcus multilocularis EmuJ_000139050   double strand break repair protein MRE11A
Giardia lamblia GL50803_14493   Mre11, putative
Homo sapiens ENSG00000020922   MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Leishmania braziliensis LbrM.27.2030   endo/exonuclease Mre11, putative
Leishmania donovani LdBPK_271790.1   endo/exonuclease Mre11, putative
Leishmania infantum LinJ.27.1790   endo/exonuclease Mre11, putative
Leishmania major LmjF.27.1890   endo/exonuclease Mre11, putative
Leishmania mexicana LmxM.27.1890   endo/exonuclease Mre11, putative
Loa Loa (eye worm) LOAG_00022   hypothetical protein
Mus musculus ENSMUSG00000031928   meiotic recombination 11 homolog A (S. cerevisiae)
Neospora caninum NCLIV_067970   double-strand break repair protein, putative
Oryza sativa 4337137   Os04g0635900
Plasmodium berghei PBANKA_0205600   double-strand break repair protein MRE11, putative
Plasmodium falciparum PF3D7_0107800   double-strand break repair protein MRE11
Plasmodium knowlesi PKNH_0205800   double-strand break repair protein MRE11, putative
Plasmodium vivax PVX_081385   double-strand break repair protein MRE11, putative
Plasmodium yoelii PY06177   rad32-related
Saccharomyces cerevisiae YMR224C   Mre11p
Schistosoma japonicum Sjp_0069970   Double-strand break repair protein MRE11A, putative
Schistosoma mansoni Smp_068110   meiotic recombination repair protein 11 (mre11)
Schmidtea mediterranea mk4.014816.00   Mre11-like protein
Schmidtea mediterranea mk4.006709.01   Double-strand break repair protein MRE11A
Trypanosoma brucei gambiense Tbg.972.2.2460   endo/exonuclease Mre11, putative
Trypanosoma brucei Tb927.2.4390   endo/exonuclease Mre11
Trypanosoma congolense TcIL3000_2_790   endo/exonuclease Mre11, putative
Trypanosoma cruzi TcCLB.509099.70   endo/exonuclease Mre11, putative
Trypanosoma cruzi TcCLB.509319.60   endo/exonuclease Mre11, putative
Toxoplasma gondii TGME49_278060   Mre11 DNA-binding domain-containing protein
Theileria parva TP04_0621   DNA repair exonuclease, putative
Trichomonas vaginalis TVAG_098295   nuclease Mre11

Essentiality

PF3D7_0107800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.4390 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZC302.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_278060 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens MRE11 meiotic recombination 11 homolog A (S. cerevisiae) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0107800 (Plasmodium falciparum), double-strand break repair protein MRE11
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