Detailed view for PF3D7_0821100

Basic information

TDR Targets ID: 829902
Plasmodium falciparum, protein kinase 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.7193 | Length (AA): 918 | MW (Da): 107246 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 25 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 112 1u5q (A) 14 107 31.00 0.034 0.88 0.274354 0.01
32 106 4equ (B) 33 108 35.00 0.22 0.86 0.364299 0.84
35 111 4mvf (A) 72 147 47.00 0.00052 0.77 0.376478 0.75
174 262 3ult (A) 26 118 34.00 0.036 0.23 0.44655 -1.06
615 885 3eb0 (A) 67 375 31.00 0.000000000011 0.92 0.543907 0.3
670 841 3eb0 (A) 164 330 44.00 0 0.98 0.621964 0.34
692 886 4e7w (A) 177 362 45.00 0 1 0.605018 0.58
692 835 2b9h (A) 151 308 39.00 0.000000000055 1 0.529463 0.18
692 839 3pg1 (A) 172 322 38.00 0.000000000033 1 0.41082 0.51
692 750 1s9i (A) 208 264 49.00 0.23 0.24 0.22687 2.12
715 835 2i6l (A) 194 315 36.00 0.0000000076 0.88 0.533408 -0.33
717 837 3gbz (A) 181 302 40.00 0.000000000022 1 0.650508 -0.72
36 112 4mvf (A) 72 147 47.00 0.00053 0.77 0.376851 0.75
36 113 4uyn (A) 133 212 33.00 0.35 0.7 0.252963 0.73
45 115 2zv2 (A) 173 272 40.00 0.11 0.9 0.439177 0.49
175 261 3ult (A) 26 108 30.00 0.37 0.06 0.411974 -0.8
570 869 4dit (A) 89 383 30.00 0.00000000005 0.92 0.474804 0.59
615 818 3gbz (A) 82 302 26.00 0.000000000055 0.96 0.552019 -0.31
627 896 3nie (A) 130 423 29.00 0 0.47 0.252734 1.12
643 823 3pg1 (A) 124 325 27.00 0.00000034 1 0.515435 -0.36
651 822 3eb0 (A) 164 330 44.00 0 0.98 0.624524 0.34
673 731 1s9i (A) 208 264 49.00 0.24 0.24 0.226828 2.12
685 866 2baj (A) 174 351 29.00 0.0000000053 1 0.356547 1.04
693 868 3n9x (A) 211 412 38.00 0.000000014 0.98 0.377873 0.64
699 814 4pdp (A) 361 463 39.00 0.65 0.92 0.269232 0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_167106)

Species Accession Gene Product
Plasmodium berghei PBANKA_0709700   protein kinase 1
Plasmodium falciparum PF3D7_0821100   protein kinase 1
Plasmodium knowlesi PKNH_1315100   protein kinase 1, putative
Plasmodium vivax PVX_089305   protein kinase, putative
Plasmodium yoelii PY05890   protein kinase-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.5 0.5
0.0093 0.8828 0
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 0.5
0.0064 0.3377 0
0.0059 1 1
0.0022 0.5 0.5
0.0063 0.7244 0.7244
0.0007 0.5 0.5
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0037 1 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0059 1 1
0.0069 0.3067 1
0.0042 0.5 0.5
0.0018 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0008 0.5 0.5
0.0029 0.5 0.5
0.0011 1 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2614
0.0039 0.5 0.5
0.0061 0.6883 1
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0821100 (Plasmodium falciparum), protein kinase 1
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