Detailed view for PF3D7_1333400

Basic information

TDR Targets ID: 83
Plasmodium falciparum, conserved protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.0107 | Length (AA): 238 | MW (Da): 28084 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01871   AMMECR1

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 247 1wsc (A) 3 208 21.00 0 1 0.92 -0.23
16 220 1wsc (A) 3 203 22.00 0 0.95 0.894745 0.74
21 225 1vaj (A) 4 197 19.00 0 0.99 0.906745 0.46
91 183 1zq7 (A) 57 152 32.00 0.79 0.13 0.372856 2.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, early schizont, Male Gametocyte. PlasmoDB Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127328)

Species Accession Gene Product
Arabidopsis thaliana AT2G38710   AMMECR1 family protein
Babesia bovis BBOV_II003340   conserved hypothetical protein
Brugia malayi Bm1_33695   AMME syndrome candidate gene 1 protein homolog, putative
Candida albicans CaO19.2047   similar to S. cerevisiae YOR289W
Candida albicans CaO19.9595   similar to S. cerevisiae YOR289W
Caenorhabditis elegans CELE_R166.3   Protein R166.3
Dictyostelium discoideum DDB_G0283437   AMMECR1 family protein
Drosophila melanogaster Dmel_CG5902   CG5902 gene product from transcript CG5902-RA
Echinococcus granulosus EgrG_000066600   AMME syndrome candidate gene 1 protein
Entamoeba histolytica EHI_067940   hypothetical protein, conserved
Entamoeba histolytica EHI_143570   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000066600   AMME syndrome candidate gene 1 protein
Giardia lamblia GL50803_9349   Hypothetical protein, similar to AMMECR1
Homo sapiens ENSG00000144233   AMMECR1-like
Homo sapiens ENSG00000101935   Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
Leishmania braziliensis LbrM.32.0710   hypothetical protein, conserved
Leishmania donovani LdBPK_320660.1   AmmeMemoRadiSam system protein A/uncharacterized protein, PH0010 family, putative
Leishmania infantum LinJ.32.0660   hypothetical protein, conserved
Leishmania major LmjF.32.0630   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0630   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09146   hypothetical protein
Loa Loa (eye worm) LOAG_06836   hypothetical protein
Mus musculus 56068   Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
Mus musculus ENSMUSG00000041915   AMME chromosomal region gene 1-like
Neospora caninum NCLIV_047300   AMMECR1 family protein, related
Neospora caninum NCLIV_017320   Similar to uniprot
Oryza sativa 4349471   Os10g0573100
Onchocerca volvulus OVOC2822  
Plasmodium berghei PBANKA_1348100   conserved protein, unknown function
Plasmodium falciparum PF3D7_1333400   conserved protein, unknown function
Plasmodium knowlesi PKNH_1267200   conserved protein, unknown function
Plasmodium vivax PVX_082600   hypothetical protein, conserved
Plasmodium yoelii PY02102   Protein of unknown function, putative
Saccharomyces cerevisiae YOR289W   hypothetical protein
Schistosoma japonicum Sjp_0037400   AMME syndrome candidate gene 1 protein, putative
Schistosoma mansoni Smp_075640.3   ammecr1 homolog
Schistosoma mansoni Smp_075640.2   ammecr1 homolog
Schistosoma mansoni Smp_075640.1   ammecr1 homolog
Schmidtea mediterranea mk4.000265.03   Putative ammecr1 homolog
Schmidtea mediterranea mk4.000089.00   Putative ammecr1 homolog
Schmidtea mediterranea mk4.000265.04  
Trypanosoma brucei gambiense Tbg972.11.15490   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.13870   uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative
Trypanosoma congolense TcIL3000.11.14240   uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative
Trypanosoma cruzi TcCLB.509161.60   uncharacterized protein, PH0010 family/AmmeMemoRadiSam system protein A, putative
Toxoplasma gondii TGME49_225413   hypothetical protein
Toxoplasma gondii TGME49_242000   DUF51 family protein
Theileria parva TP04_0257   hypothetical protein, conserved
Trichomonas vaginalis TVAG_130770   conserved hypothetical protein
Trichomonas vaginalis TVAG_326010   conserved hypothetical protein

Essentiality

PF3D7_1333400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5440 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5440 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5440 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.5440 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1348100 Plasmodium berghei Dispensable plasmo
TGME49_242000 Toxoplasma gondii Probably non-essential sidik
TGME49_225413 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pkno004248AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pkno004248; Recombinant protein: full-length; Source: P knowlesi; hypothetical protein, conserved homolog ; Identifier: PKH_121950

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1333400 (Plasmodium falciparum), conserved protein, unknown function
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