Detailed view for TP04_0725

Basic information

TDR Targets ID: 832099
Theileria parva, glutamate transporter, putative
Source Database / ID: 

pI: 8.7835 | Length (AA): 463 | MW (Da): 52594 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00375   Sodium:dicarboxylate symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0015293   symporter activity  
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 461 5lm4 (A) 41 486 21.00 0 0.57 1.03596 0.31
30 445 2nwl (A) 12 408 16.00 0 0.9 0.979188 0.12
168 221 5gol (A) 17 73 39.00 0.96 0.18 0.422231 0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126739)

Species Accession Gene Product
Brugia malayi Bm1_42930   Excitatory amino acid transporter
Caenorhabditis elegans CELE_C12D12.2   Protein GLT-1, isoform B
Caenorhabditis elegans CELE_Y53C12A.2   Protein GLT-5
Caenorhabditis elegans CELE_T22E5.2   Protein GLT-4
Caenorhabditis elegans CELE_R05G6.6   Protein GLT-6
Chlamydia trachomatis CT_401   glutamate symporter
Drosophila melanogaster Dmel_CG3747   Excitatory amino acid transporter 1
Drosophila melanogaster Dmel_CG3159   Excitatory amino acid transporter 2
Escherichia coli b3528   C4-dicarboxylic acid, orotate and citrate transporter
Escherichia coli b4077   glutamate/aspartate:proton symporter
Echinococcus granulosus EgrG_000819900   Excitatory amino acid transporter
Echinococcus granulosus EgrG_000812100   excitatory amino acid transporter 2
Echinococcus granulosus EgrG_000820100   Excitatory amino acid transporter
Echinococcus granulosus EgrG_000469500   sodium:dicarboxylate symporter
Echinococcus granulosus EgrG_000751200   neutral amino acid transporter
Echinococcus granulosus EgrG_001182500   excitatory amino acid transporter 3
Echinococcus granulosus EgrG_001168200   neutral amino acid transporter A
Echinococcus granulosus EgrG_000668500   excitatory amino acid transporter 2
Echinococcus granulosus EgrG_001168300   neutral amino acid transporter A
Echinococcus multilocularis EmuJ_000751200   neutral amino acid transporter excitatory amino acid transporter
Echinococcus multilocularis EmuJ_001168200   neutral amino acid transporter A
Echinococcus multilocularis EmuJ_001168100   neutral amino acid transporter A
Echinococcus multilocularis EmuJ_000469500   sodium:dicarboxylate symporter
Echinococcus multilocularis EmuJ_001182500   excitatory amino acid transporter 3
Echinococcus multilocularis EmuJ_001168300   neutral amino acid transporter A
Echinococcus multilocularis EmuJ_000668500   excitatory amino acid transporter 2
Echinococcus multilocularis EmuJ_000820100   Excitatory amino acid transporter
Echinococcus multilocularis EmuJ_000819900   Excitatory amino acid transporter
Echinococcus multilocularis EmuJ_000812100   excitatory amino acid transporter 2
Homo sapiens ENSG00000105143   solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Homo sapiens ENSG00000106688   solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Homo sapiens ENSG00000105281   solute carrier family 1 (neutral amino acid transporter), member 5
Homo sapiens ENSG00000079215   solute carrier family 1 (glial high affinity glutamate transporter), member 3
Homo sapiens ENSG00000110436   solute carrier family 1 (glial high affinity glutamate transporter), member 2
Loa Loa (eye worm) LOAG_07869   excitatory amino acid transporter
Mus musculus ENSMUSG00000024935   solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Mus musculus ENSMUSG00000020142   solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Mus musculus ENSMUSG00000005360   solute carrier family 1 (glial high affinity glutamate transporter), member 3
Mus musculus ENSMUSG00000001918   solute carrier family 1 (neutral amino acid transporter), member 5
Mus musculus ENSMUSG00000005357   solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Mus musculus ENSMUSG00000005089   solute carrier family 1 (glial high affinity glutamate transporter), member 2
Mycobacterium tuberculosis Rv2443   Probable C4-dicarboxylate-transport transmembrane protein DctA
Onchocerca volvulus OVOC9973   Excitatory amino acid transporter homolog
Schistosoma japonicum Sjp_0123600   Excitatory amino acid transporter 2, putative
Schistosoma japonicum Sjp_0037260   ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative
Schistosoma japonicum Sjp_0037270   ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative
Schistosoma mansoni Smp_016600   solute carrier family 1 (glial high affinity glutamate transporter
Schmidtea mediterranea mk4.004152.01  
Schmidtea mediterranea mk4.001719.05  
Schmidtea mediterranea mk4.010462.02  
Schmidtea mediterranea mk4.044600.00   Sodium/dicarboxylate symporter-related
Schmidtea mediterranea mk4.016506.00   Excitatory amino acid transporter 2
Schmidtea mediterranea mk4.004152.00  
Theileria parva TP04_0725   glutamate transporter, putative
Wolbachia endosymbiont of Brugia malayi Wbm0789   Na+/H+-dicarboxylate symporter

Essentiality

TP04_0725 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2486 Mycobacterium tuberculosis non-essential nmpdr
b3528 Escherichia coli non-essential goodall
b4077 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 3 Compounds References
Rattus norvegicus Amino acid transporter Compounds References
Homo sapiens solute carrier family 1 (glial high affinity glutamate transporter), member 2 Compounds References
Rattus norvegicus Excitatory amino acid transporter 1 Compounds References
Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Compounds References
Rattus norvegicus Excitatory amino acid transporter 3 Compounds References
Homo sapiens solute carrier family 1 (neutral amino acid transporter), member 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TP04_0725 (Theileria parva), glutamate transporter, putative
Title for this comment
Comment