Detailed view for TP01_0753

Basic information

TDR Targets ID: 833995
Theileria parva, heat shock protein 75, putative
Source Database / ID: 

pI: 6.4284 | Length (AA): 724 | MW (Da): 82351 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00183   Hsp90 protein
PF13589   Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0006950   response to stress  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 722 5tth (A) 86 738 41.00 0 1 1.28498 0.08
70 286 3ied (A) 93 333 45.00 0 1 0.875824 -0.96
75 298 3k60 (A) 2 310 41.00 0 1 0.869392 -1.2
79 557 5y3n (A) 88 552 45.00 0 1 1.0847 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129844)

Species Accession Gene Product
Babesia bovis BBOV_IV010880   heat shock protein 75, putative
Brugia malayi Bm1_20215   Hsp90 protein
Caenorhabditis elegans CELE_R151.7   Protein R151.7, isoform B
Dictyostelium discoideum DDB_G0276947   heat shock protein Hsp90 family protein
Drosophila melanogaster Dmel_CG3152   CG3152 gene product from transcript CG3152-RA
Echinococcus granulosus EgrG_000866600   heat shock protein 75 kDa mitochondrial
Echinococcus multilocularis EmuJ_000866600   heat shock protein 75 kDa, mitochondrial
Homo sapiens ENSG00000126602   TNF receptor-associated protein 1
Leishmania braziliensis LbrM.33.2670   heat shock protein, putative
Leishmania donovani LdBPK_332520.1   heat shock protein, putative
Leishmania infantum LinJ.33.2520   heat shock protein, putative
Leishmania major LmjF.33.2390   heat shock protein, putative
Leishmania mexicana LmxM.32.2390   heat shock protein, putative
Loa Loa (eye worm) LOAG_05810   heat shock protein 75
Mus musculus ENSMUSG00000005981   TNF receptor-associated protein 1
Neospora caninum NCLIV_000010   heat shock protein 90, putative
Onchocerca volvulus OVOC9277   Heat shock protein 75 kDa, mitochondrial homolog
Plasmodium berghei PBANKA_0929900   heat shock protein 90, putative
Plasmodium falciparum PF3D7_1118200   heat shock protein 90, putative
Plasmodium knowlesi PKNH_0915900   heat shock protein 90, putative
Plasmodium vivax PVX_091545   heat shock protein 90, putative
Plasmodium yoelii PY05217   Hsp90-related
Schistosoma japonicum Sjp_0300620   ko:K09488 TNF receptor-associated protein 1, putative
Schistosoma mansoni Smp_155740   heat shock protein
Schmidtea mediterranea mk4.019078.00   Heat shock protein 75 kDa, mitochondrial
Schmidtea mediterranea mk4.072099.00   Heat shock protein 90
Schmidtea mediterranea mk4.018361.00   Heat shock protein 75 kDa, mitochondrial
Trypanosoma brucei gambiense Tbg972.11.2900   heat shock protein, mitochondrial precursor, putative,TNFR-associated protein 1
Trypanosoma brucei Tb927.11.2650   heat shock protein 84, putative
Trypanosoma congolense TcIL3000.11.2400   heat shock protein, mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.504153.310   heat shock protein, putative
Toxoplasma gondii TGME49_292920   heat shock protein 75, putative
Theileria parva TP01_0753   heat shock protein 75, putative

Essentiality

TP01_0753 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.0250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.0250 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.0250 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.0250 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_292920 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum heat shock protein 90, putative Compounds References
Homo sapiens TNF receptor-associated protein 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TP01_0753 (Theileria parva), heat shock protein 75, putative
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