pI: 10.8362 |
Length (AA): 265 |
MW (Da): 30328 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
37 | 173 | 3llo (A) | 506 | 718 | 31.00 | 0.000000000091 | 1 | 0.952581 | -0.91 |
61 | 164 | 1vc1 (A) | 9 | 110 | 19.00 | 0 | 1 | 0.826953 | -2.05 |
63 | 172 | 4dgf (A) | 451 | 559 | 18.00 | 0 | 1 | 0.864394 | -1.99 |
69 | 175 | 4dgh (A) | 445 | 550 | 18.00 | 0.00011 | 0.99 | 0.848174 | -1.73 |
96 | 246 | 3g89 (A) | 15 | 187 | 29.00 | 0.6 | 0.31 | 0.597411 | 0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Ortholog group members (OG5_126650)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19600 | 5 |
Arabidopsis thaliana | AT4G08620 | 1 |
Arabidopsis thaliana | AT4G02700 | 2 |
Arabidopsis thaliana | AT3G15990 | 4 |
Arabidopsis thaliana | AT1G22150 | 3 |
Arabidopsis thaliana | AT5G13550 | 1 |
Arabidopsis thaliana | AT1G23090 | sulfate transporter 3.3 |
Arabidopsis thaliana | AT1G77990 | sulfate transporter 2 |
Arabidopsis thaliana | AT5G10180 | 1 |
Arabidopsis thaliana | AT1G78000 | 2 |
Arabidopsis thaliana | AT3G12520 | 2 |
Arabidopsis thaliana | AT3G51895 | 1 |
Brugia malayi | Bm1_44800 | sulfate permease family protein |
Candida albicans | CaO19.9696 | similar to S. cerevisiae YPR003C |
Candida albicans | CaO19.10252 | one of three potential sulfate transporter genes |
Candida albicans | CaO19.2149 | similar to S. cerevisiae YPR003C |
Caenorhabditis elegans | CELE_ZK287.2 | Protein SULP-8, isoform A |
Caenorhabditis elegans | CELE_K12G11.1 | Protein SULP-4 |
Caenorhabditis elegans | CELE_K12G11.2 | Protein SULP-5 |
Caenorhabditis elegans | CELE_F14D12.5 | Protein SULP-2 |
Cryptosporidium hominis | Chro.70021 | high affinity sulfate transporter-related |
Cryptosporidium parvum | cgd7_90 | high affinity sulfate transporter-related |
Dictyostelium discoideum | DDB_G0268074 | hypothetical protein |
Dictyostelium discoideum | DDB_G0276663 | hypothetical protein |
Dictyostelium discoideum | DDB_G0268060 | hypothetical protein |
Dictyostelium discoideum | DDB_G0286611 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG7005 | Epidermal stripes and patches |
Drosophila melanogaster | Dmel_CG5485 | CG5485 gene product from transcript CG5485-RA |
Drosophila melanogaster | Dmel_CG9717 | CG9717 gene product from transcript CG9717-RA |
Drosophila melanogaster | Dmel_CG5002 | CG5002 gene product from transcript CG5002-RA |
Drosophila melanogaster | Dmel_CG7912 | CG7912 gene product from transcript CG7912-RA |
Drosophila melanogaster | Dmel_CG9702 | CG9702 gene product from transcript CG9702-RA |
Drosophila melanogaster | Dmel_CG6928 | CG6928 gene product from transcript CG6928-RD |
Echinococcus granulosus | EgrG_000868450 | solute carrier family 26 prestin |
Echinococcus multilocularis | EmuJ_000724200 | solute carrier family 26 |
Echinococcus multilocularis | EmuJ_000868450 | solute carrier family 26, (prestin) |
Homo sapiens | ENSG00000225697 | solute carrier family 26 (anion exchanger), member 6 |
Homo sapiens | ENSG00000181045 | solute carrier family 26 (anion exchanger), member 11 |
Homo sapiens | ENSG00000170615 | solute carrier family 26 (anion exchanger), member 5 |
Leishmania braziliensis | LbrM.30.0850 | sulfate transporter-like protein |
Leishmania donovani | LdBPK_281810.1 | sulfate transporter-like protein |
Leishmania infantum | LinJ.28.1810 | sulfate transporter-like protein |
Leishmania major | LmjF.28.1690 | sulfate transporter-like protein |
Leishmania mexicana | LmxM.28.1690 | sulfate transporter-like protein |
Loa Loa (eye worm) | LOAG_04536 | sulfate permease |
Loa Loa (eye worm) | LOAG_11998 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13655 | hypothetical protein |
Mus musculus | ENSMUSG00000023259 | solute carrier family 26, member 6 |
Mus musculus | ENSMUSG00000039908 | solute carrier family 26, member 11 |
Mus musculus | ENSMUSG00000029015 | solute carrier family 26, member 5 |
Mycobacterium tuberculosis | Rv1739c | Probable sulphate-transport transmembrane protein ABC transporter |
Neospora caninum | NCLIV_056370 | hypothetical protein |
Oryza sativa | 4345528 | Os08g0406400 |
Oryza sativa | 9266924 | Os01g0593700 |
Oryza sativa | 4331935 | Os03g0195800 |
Oryza sativa | 4331703 | Os03g0161200 |
Oryza sativa | 4331932 | Os03g0195300 |
Oryza sativa | 4340095 | Os06g0143700 |
Oryza sativa | 4331937 | Os03g0196000 |
Oryza sativa | 4346475 | Os09g0240500 |
Oryza sativa | 4337235 | Os04g0652400 |
Oryza sativa | 4324697 | Os01g0719300 |
Onchocerca volvulus | OVOC1629 |
|
Saccharomyces cerevisiae | YPR003C | hypothetical protein |
Saccharomyces cerevisiae | YBR294W | Sul1p |
Saccharomyces cerevisiae | YLR092W | Sul2p |
Schistosoma japonicum | Sjp_0011080 | expressed protein |
Schistosoma japonicum | Sjp_0114830 | Chloride anion exchanger, putative |
Schistosoma japonicum | Sjp_0206530 | ko:K04602 cadherin EGF LAG seven-pass G-type receptor 3 (flamingo), putative |
Schistosoma japonicum | Sjp_0128740 | Solute carrier family 26 member 6, putative |
Schistosoma mansoni | Smp_145320 | sulfate transporter |
Schmidtea mediterranea | mk4.004847.00 | Testis anion transporter 1 |
Schmidtea mediterranea | mk4.016110.00 | Putative sulfate transporter |
Schmidtea mediterranea | mk4.017286.00 | Testis anion transporter 1 |
Schmidtea mediterranea | mk4.009555.04 | |
Schmidtea mediterranea | mk4.010473.00 | Testis anion transporter 1 |
Schmidtea mediterranea | mk4.009555.03 | |
Schmidtea mediterranea | mk4.000324.01 | |
Schmidtea mediterranea | mk4.004847.01 | Putative sulfate transporter |
Schmidtea mediterranea | mk4.028097.00 | |
Schmidtea mediterranea | mk4.009555.02 | Testis anion transporter 1 |
Schmidtea mediterranea | mk4.004094.00 | Putative sulfate transporter |
Schmidtea mediterranea | mk4.005240.01 | |
Schmidtea mediterranea | mk4.000324.02 | Sodium-independent sulfate anion transporter |
Schmidtea mediterranea | mk4.009555.00 | |
Schmidtea mediterranea | mk4.021966.00 | Putative sulfate transporter |
Toxoplasma gondii | TGME49_324900 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1769 | Mycobacterium tuberculosis | non-essential | nmpdr |
TGME49_324900 this record | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.