pI: 10.5169 |
Length (AA): 134 |
MW (Da): 15033 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
25 | 130 | 1wgv (A) | 5 | 113 | 24.00 | 0.000000000012 | 1 | 1.16154 | -0.91 |
25 | 134 | 3qor (A) | 155 | 267 | 27.00 | 0 | 0.81 | 1.2424 | -1.01 |
41 | 126 | 2o30 (A) | 6 | 88 | 23.00 | 0.0000077 | 0.84 | 0.951291 | -0.86 |
42 | 116 | 2o30 (A) | 7 | 79 | 27.00 | 0 | 1 | 0.959502 | -1.13 |
42 | 115 | 2cr0 (A) | 20 | 95 | 43.00 | 0.000000000006 | 1 | 1.13184 | -0.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_128369)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53400 | protein BOBBER 1 |
Arabidopsis thaliana | AT4G27890 | protein BOBBER 2 |
Babesia bovis | BBOV_III002520 | nuclear movement family protein |
Brugia malayi | Bm1_07390 | Nuclear movement protein |
Caenorhabditis elegans | CELE_F53A2.4 | Protein NUD-1 |
Cryptosporidium hominis | Chro.70486 | nuclear distribution gene C |
Cryptosporidium parvum | cgd7_4390 | NudC ortholog |
Dictyostelium discoideum | DDB_G0286159 | nuclear migration protein nudC |
Drosophila melanogaster | Dmel_CG9710 | CG9710 gene product from transcript CG9710-RB |
Echinococcus granulosus | EgrG_000463400 | nuclear migration protein nudc |
Entamoeba histolytica | EHI_130990 | nuclear movement protein, putative |
Echinococcus multilocularis | EmuJ_000463400 | nuclear migration protein nudc |
Homo sapiens | ENSG00000090273 | nudC nuclear distribution protein |
Leishmania braziliensis | LbrM.14.0460 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_140460.1 | N-terminal conserved domain of Nudc./CS domain containing protein, putative |
Leishmania infantum | LinJ.14.0460 | hypothetical protein, conserved |
Leishmania major | LmjF.14.0450 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.0450 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_15089 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06827 | hypothetical protein |
Mus musculus | ENSMUSG00000028851 | nuclear distribution gene C homolog (Aspergillus) |
Neospora caninum | NCLIV_033320 | hypothetical protein |
Oryza sativa | 4340572 | Os06g0231300 |
Plasmodium berghei | PBANKA_1350600 | nuclear movement protein, putative |
Plasmodium falciparum | PF3D7_1336800 | nuclear movement protein, putative |
Plasmodium knowlesi | PKNH_1264500 | nuclear movement protein, putative |
Plasmodium vivax | PVX_082770 | nuclear movement protein, putative |
Plasmodium yoelii | PY06251 | nuclear distribution gene C homolog |
Schistosoma japonicum | Sjp_0072200 | Nuclear migration protein nudC, putative |
Schistosoma mansoni | Smp_103320 | nuclear movement protein nudc |
Schmidtea mediterranea | mk4.009652.00 | Nuclear migration protein nudC |
Schmidtea mediterranea | mk4.002934.08 | Nuclear migration protein nudC |
Trypanosoma brucei gambiense | Tbg972.7.4850 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.4290 | Nuclear distribution protein C homolog |
Trypanosoma congolense | TcIL3000_7_3480 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508089.30 | N-terminal conserved domain of Nudc./CS domain containing protein, putative |
Trypanosoma cruzi | TcCLB.508857.50 | N-terminal conserved domain of Nudc./CS domain containing protein, putative |
Toxoplasma gondii | TGME49_233680 | nuclear movement family protein |
Toxoplasma gondii | TGME49_324500 | nuclear distribution protein C, putative |
Theileria parva | TP01_0519 | hypothetical protein |
Trichomonas vaginalis | TVAG_310240 | nuclear movement protein nudc, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4290 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4290 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.4290 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F53A2.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F53A2.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F53A2.4 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1350600 | Plasmodium berghei | Essential | plasmo |
TGME49_233680 | Toxoplasma gondii | Probably essential | sidik |
TGME49_324500 this record | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.